Histological Findings in Patients With Cryptorchidism and Testis-Epididymis Nonfusion

Kraft, Kate H.; Mucksavage, Phillip; Canning, Douglas A.; Snyder, Howard M.; Kolon, Thomas F.

doi:10.1016/j.juro.2011.07.037

Cited by 20 publications

(24 citation statements)

References 14 publications

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“…The most severe form of epididymal nonfusion, complete nonfusion, was found in 2.6% of UDTs. This is identical to the incidence of 2.2, 2.3, 4 and 5% reported in the literature [2,3,6,9]. Furthermore, we for the first time analyzed the incidence of complete nonfusion as a separate entity in the group of patients with CDT.…”

Section: Discussionsupporting

confidence: 80%

“…Anomalies caused by disturbances of fusion between the testis and epididymis range from mild to severe [1,2,3,4,5,6,7,8,9]. In our cohort, 11% of UDTs displayed some degree of epididymis-testis nonfusion.…”

Section: Discussionmentioning

confidence: 80%

“…Furthermore, we for the first time analyzed the incidence of complete nonfusion as a separate entity in the group of patients with CDT. This is the primary difference from the study by Kraft et al [9], who analyzed the incidence of nonfusion in CDT as a whole, including head and tail abnormalities. Noticeably, we did not find a single contralateral descended testis with complete epididymis nonfusion, although we analyzed, in part, the same data.…”

Section: Discussionmentioning

confidence: 81%

“…Fusion anomalies of the epididymis and testis, ascertained during orchidopexy, are associated with cryptorchidism [1,2,3,4,5,6,7,8,9]. The role of these anomalies in the process of epididymotesticular descent is controversial [1,2,3,4,5,6,7,8,9,10].…”

Section: Introductionmentioning

confidence: 99%

“…The role of these anomalies in the process of epididymotesticular descent is controversial [1,2,3,4,5,6,7,8,9,10]. Furthermore, an intimate association was described between epididymal changes, especially epididymotesticular nonunion, and retarded testicular development, indicated by severe histological changes in the testis [4].…”

Section: Introductionmentioning

confidence: 99%

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Complete Testis-Epididymis Nonfusion Anomaly: A Typical Association with Cryptorchid Testis

Rachmani

Zachariou²,

Snyder³

et al. 2012

Urol Int

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Introduction: Fusion anomalies of the testis and epididymis are associated with cryptorchidism. We present an analysis of the fusion anomalies of the epididymis in cryptorchid boys. Patients and Methods: We performed a retrospective review of patients presenting with undescended testes between 1986 and 1993. Patients were stratified among four groups based on the degree of testis-epididymis nonfusion. Results: A total of 880 testes were eligible for review, of which 93% (815/880) had normal fusion, 3.6% (32/880) had epididymal head nonfusion, 2% (19/880) had epididymal tail nonfusion, and 1.6% (14/880) had complete nonfusion. Increasing degree of nonfusion was associated with higher perioperative testes position. Head and tail nonfusion were observed together with a contralateral descended testis, but less frequently than in bilateral undescended testes (p = 3.89×E–10). Complete nonfusion was not observed in the contralateral descended testes in unilateral cryptorchid boys. Conclusions: Different degrees of fusion anomalies of the epididymis are associated with unilateral and bilateral undescended testis, indicating that nonfusion anomalies interact with epididymal-testicular descent because of impaired epididymal function.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Complete Testis-Epididymis Nonfusion Anomaly: A Typical Association with Cryptorchid Testis

Rachmani

Zachariou²,

Snyder³

et al. 2012

Urol Int

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Male Genitourinary System

Shepard

Gayheart

Joseph

2016

Bergman's Comprehensive Encyclopedia of Human Anatomic Variation

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Therapy in Oligozoospermia (Varicocele, Cryptorchidism, Inflammation, and Seminal Tract Infections)

Busetto

Saleh

Gül

et al. 2022

Practical Clinical Andrology

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The management of infertile men with varicocele is highly debated. Varicocele repair (VR) can be either surgical (varicolectomy) or through angiographic embolization. Surgical repair of varicocele includes open non-microsurgical techniques whether inguinal (Ivanissevich) or high retroperitoneal ligation (Palomo), open microsurgical techniques (inguinal or sub-inguinal) or laparoscopic. The accumulating evidence suggests that VR can improve conventional sperm parameters (sperm concentration, motility, and morphology), seminal oxidative stress, sperm DNA fragmentation, and serum testosterone concentrations.Treatment of cryptorchism is based on surgical correction. The surgical approach for palpable undescended testis is inguinal orchidopexy with eventual repair of concomitant hernia. Scrotal surgical approach is a viable alternative. For nonpalpable undescended testis, surgical approach can be open or laparoscopic, in one or two stages and possibly with spermatic vessel transection. In some cases, orchiectomy is required (testis abdominal localization, impossibility of mobilization or high neoplastic risk).Male accessory gland infections, including infection and/or inflammation of accessory glands (prostate, seminal vesicles, and Cowper’s glands), and male genital tract infections are characterized by the presence of an elevated number of leukocytes and/or pathogens in semen, together with inflammatory signs. Management is based on different antibiotic therapies.

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Histological Findings in Patients With Cryptorchidism and Testis-Epididymis Nonfusion

Cited by 20 publications

References 14 publications

Complete Testis-Epididymis Nonfusion Anomaly: A Typical Association with Cryptorchid Testis

Complete Testis-Epididymis Nonfusion Anomaly: A Typical Association with Cryptorchid Testis

Male Genitourinary System

Therapy in Oligozoospermia (Varicocele, Cryptorchidism, Inflammation, and Seminal Tract Infections)

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