Histological features and prognostic significance of treatment effect in lymph node metastasis in head and neck squamous cell carcinoma

Scherpelz, Kathryn P; Wong, Anthony; Lingen, Mark W.; Taxy, Jerome B.

doi:10.1111/his.13742

Cited by 5 publications

(5 citation statements)

References 23 publications

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“…As one of the most important causes of poor prognosis, there are an increasing number of studies concerning tumor metastasis in HNSCC (refs. 22,23 ). This study demonstrates that the interaction between IL-8 and PTEN inactivation plays a critical role in this process through STAT3 activation.…”

Section: Discussionmentioning

confidence: 99%

The interaction of interleukin-8 and PTEN inactivation promotes the malignant progression of head and neck squamous cell carcinoma via the STAT3 pathway

Feng

et al. 2020

Cell Death Dis

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Interleukin-8 (IL-8) expression correlates with poor prognosis in many cancers, including head and neck squamous cell carcinoma (HNSCC), but the underlying mechanism is poorly understood. In this study, we found that overexpression of IL-8 correlated with poor outcome in HNSCC patients. IL-8 significantly increased cellular proliferation, migration, and invasion ability both in vitro and in vivo, which could be blocked by a CXCR1/2 inhibitor. IL-8 promoted the expression of MMP2, MMP9, snail, and vimentin in HNSCC cells. Furthermore, IL-8 could inactivate PTEN via phosphorylation, and then inactivated PTEN affected the phosphorylation of STAT3. Recombinant PTEN that internalized in cytoplasm decreased the expression of phosphorylated STAT3, while knockdown of PTEN led to the increased expression of phosphorylated STAT3. A STAT3 inhibitor could reverse the upregulation of invasionassociated proteins mediated by IL-8 stimulation. Furthermore, overexpression of snail and inactivated PTEN jointly promoted the autocrine effect of IL-8 on tumor cells. Last, there were positive correlations between IL-8 and snail, vimentin expression in HNSCC tissues. In summary, our study demonstrates that PTEN acts as a novel "molecular switch" to regulate IL-8/STAT3 signaling, promoting the progression of HNSCC, and indicating that this pathway may be a potential therapeutic target for HNSCC.

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Section: Discussionmentioning

confidence: 99%

The interaction of interleukin-8 and PTEN inactivation promotes the malignant progression of head and neck squamous cell carcinoma via the STAT3 pathway

Feng

et al. 2020

Cell Death Dis

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“…3 The metastasis of even one lymph node (stage: N1) reduces the better prognosis of patients by 50%. 4 However, bilateral metastatic reduces the prognosis or survival by additional 25%. 5 Nodal metastasis can invade adjacent muscle, bone, neural or vascular structure, 4 if left untreated disease in neck may be associated with higher incidence of distant metastasis.…”

Section: Introductionmentioning

confidence: 99%

“…4 However, bilateral metastatic reduces the prognosis or survival by additional 25%. 5 Nodal metastasis can invade adjacent muscle, bone, neural or vascular structure, 4 if left untreated disease in neck may be associated with higher incidence of distant metastasis. 6 So, the detection of metastasis is important step at initial level and then the prevention of lymph node metastasis is very important features for the successful management and good prognosis of head and neck carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Accuracy of Magnetic Resonance Imaging for Detection of Metastatic Cervical Nodes at Level I and II in Patients with Oral Squamous Cell Carcinoma Taking Postoperative Histopathology as Gold Standard

Nauman¹,

Rahim²,

Ali³

et al. 2023

PJMHS

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Background: Head and neck carcinoma is the malignant lesions which develops on lips, oral cavity, nasal mucosa, paranasal sinuses, inside or outside the throat or parotid glands. Magnetic resonance imaging can be a good alternative to invasive procedures for detection of metastatic disease in cases of head and neck tumors. Objective: To evaluate diagnostic accuracy of magnetic resonance imaging in detecting metastasis in neck nodes of oral squamous cell carcinoma with reference to postoperative neck histopathology. Study Design: Cross sectional study Place and Duration of Study: Department of Oral and Maxillofacial Surgery, Mayo Hospital Lahore from 1st January 2014 to 30th June 2014. Methodology: Eighty seven patients with biopsy proven squamous cell carcinoma of orofacial origin were enrolled who had single malignant tumor at the time of diagnosis. Results: The mean age of the patients was 50.44±12.44 years. There were 58 (66.67%) males and 29 (33.33%) females. In terms of sensitivity, specificity, and diagnostic accuracy, magnetic resonance imaging was 94.12%, 61.11%, and 80.46% respectively taking histopathology as gold standard. Conclusion: For the detection of cervical nodal metastases in oral squamous cell carcinoma, MRI is a useful and trustworthy method with a high sensitivity and specificity, especially when compared to postoperative neck histopathology. Keywords: Histopathology, Carcinoma, Magnetic resonance imaging (MRI),Metastasis

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“…Recently, a multicenter epidemiology study in the USA showed that patients with LNM had an approximate 50% lower five-year OS than those without [1]. Despite several attempts to identify biomarkers related to LNM in HNSCC [6][7][8][9][10], not much is known about the molecular mechanism of LNM [11,12]. Moreover, patients with LNM have not benefited much from advances in therapy [2,13].…”

Section: Introductionmentioning

confidence: 99%

TBC1D14 inhibits autophagy to suppress lymph node metastasis in head and neck squamous cell carcinoma by downregulating macrophage erythroblast attacher

Lu¹,

Li²,

Pan³

et al. 2022

Int. J. Biol. Sci.

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Aims: This study aimed to identify the correlation and molecular mechanism between TBC1 domain family member 14 (TBC1D14) and lymph node metastasis (LNM) in head and neck squamous cell carcinoma (HNSCC). Methods: Whole transcriptome sequencing of HNSCC tissues with or without LNM was performed. TBC1D14 expression was quantified in HNSCC tissues. The role of TBC1D14 in HNSCC migration, invasion, autophagy, and LNM was investigated by wound healing, Transwell, western blotting, immunofluorescence, and transmission electron microscopy assays in vitro and in a mouse model in vivo. The correlation between autophagy and LNM was detected by wound healing and Transwell assays in vitro and western blotting in vivo. Mass spectrometry was used to identify the downstream target proteins. The correlation between TBC1D14 expression and macrophage erythroblast attacher (MAEA) expression was identified by qRT-PCR and western blotting assays in vitro and immunohistochemistry in vivo. The gain-of-function strategy was applied to further reveal the role of MAEA in the TBC1D14-induced autophagy of HNSCC cells. Results: TBC1D14 was a co-differentially expressed gene in the sequencing results, The Cancer Genome Atlas Data Portal, and Gene Expression Omnibus databases. TBC1D14 had a lower RNA and protein expression in HNSCC with LNM samples and was a favorable prognostic indicator. TBC1D14 inhibited the migration and invasion of HNSCC in vivo. Mechanistically, TBC1D14-induced autophagy suppression inhibited the migration and invasion of HNSCC. TBC1D14 expression negatively correlated with MAEA expression both in vitro and in vivo. Furthermore, MAEA overexpression could reverse TBC1D14-induced autophagy suppression. Conclusion: TBC1D14 is a novel LNM inhibitor in HNSCC and a favorable prognostic marker. TBC1D14 suppresses autophagy to inhibit LNM in HNSCC by downregulating MAEA expression. The results clarify the molecular mechanism of TBC1D14 in HNSCC.

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Histological features and prognostic significance of treatment effect in lymph node metastasis in head and neck squamous cell carcinoma

Cited by 5 publications

References 23 publications

The interaction of interleukin-8 and PTEN inactivation promotes the malignant progression of head and neck squamous cell carcinoma via the STAT3 pathway

The interaction of interleukin-8 and PTEN inactivation promotes the malignant progression of head and neck squamous cell carcinoma via the STAT3 pathway

Diagnostic Accuracy of Magnetic Resonance Imaging for Detection of Metastatic Cervical Nodes at Level I and II in Patients with Oral Squamous Cell Carcinoma Taking Postoperative Histopathology as Gold Standard

TBC1D14 inhibits autophagy to suppress lymph node metastasis in head and neck squamous cell carcinoma by downregulating macrophage erythroblast attacher

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