Histological Evaluation of Thyroid Carcinomas: Reproducibility of the «Who» Classification

Fassina, Ambrogio; Montesco, Maria Cristina; Ninfo, Vito; Denti, Paolo; Masarotto, Guido

doi:10.1177/030089169307900506

Cited by 43 publications

(26 citation statements)

References 52 publications

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“…Furthermore, reliable prognostic markers are still insufficient. The most prominent interobserver variability has been reported in follicular-patterned tumors [175][176][177][178]. Final agreement for reported criteria such as capsular or vascular invasion and differential diagnosis of follicular adenoma and carcinoma is very low (27,20 and 37%, respectively) [177].…”

Section: Molecular Targets In Histopathological Diagnosis and Classifmentioning

confidence: 99%

“…Final agreement for reported criteria such as capsular or vascular invasion and differential diagnosis of follicular adenoma and carcinoma is very low (27,20 and 37%, respectively) [177]. Some disagreements between pathologists have also been reported for classification of histological variants of PTC and FNAB [175][176][177][178].…”

Section: Molecular Targets In Histopathological Diagnosis and Classifmentioning

confidence: 99%

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An update on molecular biology of thyroid cancers

Ömür

Baran

2014

Critical Reviews in Oncology/Hematology

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Section: Molecular Targets In Histopathological Diagnosis and Classifmentioning

confidence: 99%

Section: Molecular Targets In Histopathological Diagnosis and Classifmentioning

confidence: 99%

An update on molecular biology of thyroid cancers

Ömür

Baran

2014

Critical Reviews in Oncology/Hematology

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“…2 A review of 200 thyroid tumors by seven Italian pathologists revealed good agreement for papillary and anaplastic thyroid carcinomas, moderate for medullary and poor for follicular thyroid carcinomas. 3 In another review of 41 follicular carcinomas by five experienced French thyroid pathologists, the agreement for malignancy varied from 5% among all five pathologists to 56% between two pathologists. 4 Of concern, the interobserver and intraobserver agreements for vascular invasion were only 20 and 68%, respectively.…”

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confidence: 97%

Galectin-3, fibronectin-1, CITED-1, HBME1 and cytokeratin-19 immunohistochemistry is useful for the differential diagnosis of thyroid tumors

et al. 2005

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The diagnosis of thyroid tumors is critical for clinical management; however, tumors with follicular architecture often present problems. We evaluated the diagnostic use of the protein expression of four genes that were found to be upregulated in papillary thyroid carcinoma compared to normal thyroid (LGALS3, FN1, CITED1 and KRT19), and of the mesothelial cell surface protein recognized by monoclonal antibody HBME1 in thyroid tumors. Tissues from 85 carcinomas (67 papillary, six follicular, eight Hü rthle cell and four anaplastic) and 21 adenomas were evaluated by immunohistochemistry for the expression of these gene protein products, for example, galectin-3 (GAL3), fibronectin-1 (FN1), CITED1, cytokeratin-19 (CK19) and HBME1. Non-neoplastic thyroids (29 adenomatous and 14 thyrotoxic hyperplasia, and 59 normal) were also studied. The expression of all five proteins was significantly associated with malignancy, and highly specific (Z90%) for carcinoma compared to adenoma. GAL3, FN1 and/or HBME1 expression was seen in 100% of carcinomas (85/85) and in 24% of adenomas (5/21). Coexpression of multiple proteins was seen in 95% of carcinomas and only 5% of adenomas (Po0.0001). Coexpression of FN1 and GAL3 (FN1 þ GAL3 þ , 70/85) or FN1 and HBME1 (FN1 þ HBME1 þ , 53/85) was restricted to carcinomas, while their concurrent absence (FN1ÀGAL3À or FN1ÀHBME1À, 18/21 adenoma) was highly specific (96%) for benign lesions. Among non-neoplastic thyroids, adenomatous hyperplasia frequently expressed GAL3 (n ¼ 16), CK19 (n ¼ 9) and CITED1 (n ¼ 7), but the expression was predominantly focal in contrast to the diffuse expression in carcinomas. An immunohistochemical panel consisting of GAL3, FN1 and HBME1 may be useful in the diagnosis of follicular cell-derived thyroid tumors.

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“…The reproducibility of histological classification in thyroid carcinoma has previously been addressed in a few studies (Saxen et al, 1978;Holm et al, 1980;Fassina et al, 1993;Franc et al, 1999;Hirokawa et al, 2002). In most of these studies, the review of the cases was performed separately by each observer.…”

Section: Discussionmentioning

confidence: 99%

“…However, as in Fassina's study on cancer subclassification (Fassina et al, 1993), several debates occurred during our consensus conference when we were reviewing PTC subtypes and encapsulated thyroid follicular tumours. The level of agreement differed depending on It is important to note the increased diagnosis of papillary carcinoma follicular variant in the last decade, in adult, childhood and adolescent thyroid cancer (Harach and Williams, 1995;Pacini et al, 1997;Tronko et al, 1999;Verkooijen et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Histological validation of diagnoses of thyroid cancer among adults in the registries of Belarus and the Ukraine

Franc

Valenty

Galakhin³

et al. 2003

Br J Cancer

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In order to evaluate the diagnostic reliability of the thyroid cancers listed in adult registries from the Ukraine and Belarus, a histological review was organised of 327 randomly selected thyroid carcinoma cases diagnosed between 1980 and 1999. A final diagnosis was reached at a 5-day consensus conference by six pathologists who met around a multiheaded microscope. The study concluded with a comparison between the final diagnosis and the initial diagnosis. The pathologists agreed with the initial diagnosis of malignancy in 286 cases (88%). A final diagnosis of papillary, follicular or medullary thyroid carcinoma was reached in 86, 4, and 6% of the cases respectively. In 2.8% of the cases reviewed, diagnostic discrepancies persisted. The percentage of agreement between the final diagnosis and the initial diagnosis was 93%, with a weighted k-statistic of 0.61 (confidence interval 95% (CI 95% ): [0.45 -0.77]). In all, 89% of the 286 confirmed cancer cases were in agreement for the type of cancer, with a k-statistic of 0.56 (CI 95% : [0.43 -0.69]). The level of agreement differed according to cancer categories, with concordance rates of 94, 40 and 33% for papillary, follicular and medullary thyroid carcinomas respectively. The low prevalence of follicular thyroid carcinomas in the adult population studied calls for further exploration. The discrepancies and classification difficulties encountered were analysed.

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Histological Evaluation of Thyroid Carcinomas: Reproducibility of the «Who» Classification

Abstract: Central pathology review of thyroid carcinomas is recommended when clinical and epidemiologic trials are planned.

Cited by 43 publications

References 52 publications

An update on molecular biology of thyroid cancers

An update on molecular biology of thyroid cancers

Galectin-3, fibronectin-1, CITED-1, HBME1 and cytokeratin-19 immunohistochemistry is useful for the differential diagnosis of thyroid tumors

Histological validation of diagnoses of thyroid cancer among adults in the registries of Belarus and the Ukraine

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