Histological Evaluation of the Effect of Using Growth Hormone Around Immediate Dental Implants in Fresh Extraction Sockets: An Experimental Study

Eldein, Assem M. Hossam; Elghamrawy, Sherif H.; Osman, Saeeda M.; Elhak, Amal R.

doi:10.1097/id.0b013e3182096979

Cited by 8 publications

(7 citation statements)

References 20 publications

(11 reference statements)

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“…Previous published studies available in the literature have reported that systemic administration of GH enhances the healing of bone fractures in the tibia and femur [10,11] and in calvarial defects in rats [1]. In addition, some studies have shown that local application of GH (either topical or irrigation), may also promote a direct and specific effect on bone tissues that seems to stimulate both bone deposition and the osseointegration of implants [3,4,16,17,18,23].…”

Section: Discussionmentioning

confidence: 99%

Growth hormone effects on healing efficacy, bone resorption and renal morphology of rats: histological and histometric study in rat calvaria

Giovanini

Zielak

Scariot

et al. 2020

Heliyon

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Previous reports demonstrated the utility of systemic application of growth hormone (GH) in the treatment of bone defects. Very few studies correlated bone repair efficacy with hepatic and renal side effects promoted by locally-delivered GH. The objectives of this study were to assess the bone repair properties along with hepatic and renal adverse effects promoted by local application of GH in a rat model. Thirty-two rats were randomly divided (4 groups; n = 8/group), as follows: (i) AB (autogenous bone + local application of saline solution [SS]), (ii) AB+ (autogenous bone + SS local application + SS irrigation), (iii) AB/GH+ (autogenous bone + SS local application + GH irrigation) and (iv) AB/GHL+ (autogenous bone + GH local application + GH irrigation). Critical-sized defects (diameter = 5.0 mm) were surgically created by a single operator in the calvaria of rats. Defects were filled with ground autogenous bone. Defects pertaining to AB+ and AB/GH+ received a mixture of autogenous bone and a SS-saturated (0.02 mL) collagen sponge covered with bovine cortical membrane. Defects in group AB/GHL+, were filled with the same biomaterials saturated with GH (0.02 mL). SS (0.1 mL) or GH (0.1 mL, equivalent to 0.4 IU) were applied locally on alternate days (8 weeks) in animals in groups AB, AB+ and AB/GH+ or AB/GHL+, respectively. Bone repair properties was determined in hematoxylin/eosin-stained slices using traditional histologic and histomorphometric techniques along with optical microscopy and digital image analysis. Statistical differences among groups was determined using Kruskal-Wallis and Tukey post hoc tests (α = 0.05). Histology results indicated that AB and AB+ displayed greater presence of autogenous bone as compared to AB/GH+ and AB/GHL+. Histomorphometric results indicated significantly higher osteoid matrix formation in AB and AB+ when compared to AB/GHL+ ( p = 0.009). Kidneys and livers were found to have their glomeruli preserved in AB and AB+. Strong glomeruli necrosis and large areas of protein deposition were found in AB/GH+. Abnormal small-sized glomeruli were found in AB/GHL+. The utilization of autogenous bone graft associated with local application and irrigation with GH was shown to not improve the bone repair in calvarial critical-sized defects in a rat model.

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Section: Discussionmentioning

confidence: 99%

Growth hormone effects on healing efficacy, bone resorption and renal morphology of rats: histological and histometric study in rat calvaria

Giovanini

Zielak

Scariot

et al. 2020

Heliyon

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“…Markers of bone metabolism, including serum alkaline phosphatase, procollagen 1 carboxylterminal propeptide, and deoxypyridinoline, increased significantly by GH administration [ 71 ]. Finally, GH powder application around dental implants placed immediately after tooth extraction enhances bone density and collagen fibers [ 72 , 73 ].…”

Section: Discussionmentioning

confidence: 99%

Growth Hormone and Craniofacial Tissues. An update

Litsas¹

2015

TODENTJ

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Growth hormone is an important regulator of bone homeostasis. In childhood, it determines the longitudinal bone growth, skeletal maturation, and acquisition of bone mass. In adulthood, it is necessary to maintain bone mass throughout life. Although an association between craniofacial and somatic development has been clearly established, craniofacial growth involves complex interactions of genes, hormones and environment. Moreover, as an anabolic hormone seems to have an important role in the regulation of bone remodeling, muscle enhancement and tooth development. In this paper the influence of growth hormone on oral tissues is reviewed.

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“…Sustenta-se que esses fatores são uma alternativa ao uso de enxertos, exceto o autógeno, pois esses exerceriam a função de osteoindução nesses casos. Sugere--se o seu uso em reconstruções de grandes defeitos, inclusive 27 .…”

Section: Discussão Perspectivas Da Utilização Do Gh Na Odontologiaunclassified

Hormônio do crescimento humano e a perspectiva futura em Odontologia

Pagnoncelli

Gerzson

Camilotti

et al. 2015

Rev. da Fac. de Odontologia, UPF

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Histological Evaluation of the Effect of Using Growth Hormone Around Immediate Dental Implants in Fresh Extraction Sockets: An Experimental Study

Abstract: The use of GH powder around dental implants placed immediately in fresh extraction sockets enhanced periimplant bone response.

Cited by 8 publications

References 20 publications

Growth hormone effects on healing efficacy, bone resorption and renal morphology of rats: histological and histometric study in rat calvaria

Growth hormone effects on healing efficacy, bone resorption and renal morphology of rats: histological and histometric study in rat calvaria

Growth Hormone and Craniofacial Tissues. An update

Hormônio do crescimento humano e a perspectiva futura em Odontologia

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