Histological effects of tazarotene 0.1% cream vs. vehicle on photodamaged skin: a 6-month, multicentre, double-blind, randomized, vehicle-controlled study in patients with photodamaged facial skin

Machtinger, L.A.; Kaidbey, Kays H.; Lim, Joyce; Loven, Keith; Rist, Toivo; Wilson, David C.; Parizadeh, D.D.; Sefton, John; Holland, Judith; Walker, Patricia S.

doi:10.1111/j.1365-2133.2004.06186.x

Cited by 21 publications

(22 citation statements)

References 13 publications

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“…Recent studies indicate that the skin flushing response is mediated by activation of receptors on epidermal Langerhans cells (50) or macrophages at concentrations above 0.1 mm (51). While prior studies have shown that the thickness of the stratum corneum is less in paraffin sections compared with frozen sections (52), paraffin sections have been used to assess stratum corneum morphology and changes in thickness in numerous studies (53)(54)(55)(56)(57). Using skin NAD as a biomarker of nicotinic acid delivery, MN was shown to deliver nicotinic acid to skin ( Fig.…”

Section: Discussionmentioning

confidence: 99%

A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin

Jacobson

Kim

et al. 2007

Experimental Dermatology

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The effects of myristyl nicotinate (MN), a nicotinic acid derivative designed to deliver nicotinic acid to skin without vasodilatation, on subjects with photodamaged skin have been studied. MN increased skin cell nicotinamide adenine dinucleotide (NAD) by 25% (P = 0.001) demonstrating effective delivery of nicotinic acid to skin. Relative to placebo, MN treatment of photodamaged facial skin increased stratum corneum thickness by approximately 70% (P = 0.0001) and increased epidermal thickness by approximately 20% (P = 0.001). In two separate studies, MN treatment increased rates of epidermal renewal by 6% (P = 0.003) to 11% (P = 0.001) and increased the minimal erythemal dose by 8.9 (P = 0.07) and 10% (P = 0.05) relative to placebo. MN treatment resulted in reductions in the rates of transepidermal water loss (TEWL) of approximately 20% relative to placebo on cheeks (P = 0.012) and arms (P = 0.017) of study subjects. Results of a tape stripping challenge before and after MN treatment demonstrated a significant correlation (P = 0.03) between increased skin NAD content and resistance to changes in TEWL for MN treated but not placebo subjects. Rates of TEWL changed more rapidly and to a greater extent in atopic subjects compared with normal subjects. The results indicate that MN enhances epidermal differentiation and barrier function in skin, suggesting that this method of nicotinic acid delivery may prove useful in limiting progression of actinic skin damage and possibly in treating other conditions involving skin barrier impairment.

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Section: Discussionmentioning

confidence: 99%

A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin

Jacobson

Kim

et al. 2007

Experimental Dermatology

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“…A shorter study of 6 months' duration of 0.1% tazarotene cream use in 50 patients also noted decreases in keratinocyte and melanocyte atypia at the end of the trial. 57 The above-mentioned studies raise the possibility that topical retinoids may have a place in the chemoprevention of skin cancers as well. Further clinical investigations are needed to reach a definitive conclusion.…”

Section: Vitamins As Therapymentioning

confidence: 97%

Vitamins and photoaging: Do scientific data support their use?

Zussman¹,

Ahdout²,

Kim³

2010

Journal of the American Academy of Dermatology

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“…Machtinger and colleagues (2004) evaluated the histological effects of tazarotene cream in 50 patients with photodamaged facial skin by conducting a multicentre, double-blind, randomized, vehicle-controlled study. Blinded assessments showed that the tazarotene-treated group showed amelioration of keratinocytic and melanocytic atypia compared to the vehicle-treated group.…”

Section: Tazarotenementioning

confidence: 99%

Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety

Mukherjee¹,

Date²,

Patravale³

et al. 2006

Clinical Interventions in Aging

399

318

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Aging of skin is an intricate biological process consisting of two types. While intrinsic or chronological aging is an inevitable process, photoaging involves the premature aging of skin occurring due to cumulative exposure to ultraviolet radiation. Chronological and photoaging both have clinically differentiable manifestations. Various natural and synthetic retinoids have been explored for the treatment of aging and many of them have shown histological and clinical improvement, but most of the studies have been carried out in patients presenting with photoaged skin. Amongst the retinoids, tretinoin possibly is the most potent and certainly the most widely investigated retinoid for photoaging therapy. Although retinoids show promise in the treatment of skin aging, irritant reactions such as burning, scaling or dermatitis associated with retinoid therapy limit their acceptance by patients. This problem is more prominent with tretinoin and tazarotene whereas other retinoids mainly represented by retinaldehyde and retinol are considerably less irritating. In order to minimize these side effects, various novel drug delivery systems have been developed. In particular, nanoparticles have shown a good potential in improving the stability, tolerability and efficacy of retinoids like tretinoin and retinol. However, more elaborate clinical studies are required to confirm their advantage in the delivery of topical retinoids.

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Histological effects of tazarotene 0.1% cream vs. vehicle on photodamaged skin: a 6-month, multicentre, double-blind, randomized, vehicle-controlled study in patients with photodamaged facial skin

Abstract: Treatment of photodamaged skin with tazarotene is associated with an amelioration of keratinocytic and melanocytic atypia, an improvement in epidermal polarity, and an increase in epidermal thickness.

Cited by 21 publications

References 13 publications

A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin

A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin

Vitamins and photoaging: Do scientific data support their use?

Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety

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