Histological effects of permethrin insecticide on the testis of adult wistar rats

Omotoso, Gabriel Olaiya; Onanuga, IsmailOlasile; Ibrahim, RidwanBabatunde

doi:10.4103/1947-489x.210373

Cited by 11 publications

(13 citation statements)

References 16 publications

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“…As observed in other animal groups (Yuan et al 2010;Omotoso et al 2014), we expected that insecticides would influence the production of gametes. However, our counting of meiocytes indicated that all the examined individuals from the three experimental groups had normal meiocytes at different stages, most abundantly spermatozoa.…”

Section: Chromosomesmentioning

confidence: 79%

Effects of thiamethoxam and lambda‐cyhalothrin on spermatogenesis of Euschistus heros (Heteroptera: Pentatomidae)

Aguiar

Husch

Gallo

et al. 2017

Entomological Science

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Euschistus heros (Fabricius, 1798) is one of the most harmful insect pests damaging Brazilian soybean crops and has become a major problem due to its high population density and resistance to insecticides. Currently, there are no data on whether alterations of testicular morphology and chromosomal behavior are associated with the resistance mechanisms related to the action of insecticides. This study integrated analyses of the testicular morphology, meiocyte cell division, and chromosomal structure and behavior in the process of spermatogenesis in E. heros. We compared these features among wild‐caught individuals, insecticide‐susceptible and ‐resistant strains. The resistant strain was established through a selection experiment exposing the bugs to insecticides (thiamethoxam + lambda‐cyhalothrin) for 15 generations. No differences were detected in the examined features among the three groups of experimental individuals: the testis comprised six lobes, with the fifth lobe thinner than the others; the karyotype was 2n = 14 (12 + XY), with no evident changes in chromosomal breakage, rearrangement or behavior in the meiosis; and abundant spermatozoa were observed in all testicular lobes. Thus, any effects of the long‐term (15 generations) experimental selection by exposure to the insecticides were not detected on the male germinal tissue and chromosomes, suggesting the irrelevancy of the examined features to insecticide‐resistance mechanisms in E. heros.

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Section: Chromosomesmentioning

confidence: 79%

Effects of thiamethoxam and lambda‐cyhalothrin on spermatogenesis of Euschistus heros (Heteroptera: Pentatomidae)

Aguiar

Husch

Gallo

et al. 2017

Entomological Science

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“…A very important aspect of many studies on pyrethroids is their effect on the reproductive system and fetal progression, as well as after-effects of the exposure to these substances in earlier stages [ 32 , 33 , 34 ]. The effect of a single dose, orally administered permethrin on pregnancy and fetal growth in animals has been examined [ 5 ].…”

Section: Permethrinmentioning

confidence: 99%

Current Research on the Safety of Pyrethroids Used as Insecticides

et al. 2018

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Pyrethroids are synthetic derivatives of natural pyrethrins extracted from Chrysanthemum cinerariaefolium. They are 2250 times more toxic to insects than to vertebrates due to insects’ smaller size, lower body temperature and more sensitive sodium channels. In particular, three pyrethroid compounds, namely deltamethrin, permethrin, and alpha-cypermethrin, are commonly used as insecticides and are recommended for in-home insect control because they are considered to be relatively non-toxic to humans in all stages of life. However, recent data show that they are not completely harmless to human health as they may enter the body through skin contact, by inhalation and food or water, and absorption level depending on the type of food. Permethrin seems to have an adverse effect on fertility, the immune system, cardiovascular and hepatic metabolism as well as enzymatic activity. Deltamethrin induces inflammation, nephro- and hepatotoxicity and influences the activity of antioxidant enzymes in tissues. Alpha-cypermethrin may impair immunity and act to increase glucose and lipid levels in blood. The aim of the review is to provide comprehensive information on potential hazards associated to human exposure to deltamethrin, permethrin and alpha-cypermethrin. The results of presented studies prove that the insecticides must be used with great caution.

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“…According to Omotoso et al [22] animals fed on permethrincontaining feeds exhibited some degree of damage in the general histology of their seminiferous tubules. Permethrin could directly reduce sperm motility in vitro [26].…”

Section: Discussionmentioning

confidence: 99%

“…Zhange et al [21] reported that oral administration of permethrin (35 or 70mg/kg/d) for 6 w* in adult mice, resulted in a decrease in sperm count, sperm motility, plasma and testicular testosterone concentration. Some deteriorating effects of permethrin were also reported that affect the normal architecture of the mammalian testis [22].…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Effects of Phytoandrogen and Antioxidant on Histoarchitecture of Permethrin Induced Changes in Goat Testis

Bhardwaj

Sharma

2017

Int J Pharm Pharm Sci

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Objective: Protective effects of Tribulus terrestris (TT) and vitamin C were studied against permethrin induced changes in the histoarchitecture of goat testis.Methods: Hydroalcoholic extract of the fruits of Tribulus terrestris was prepared by maceration method and the extractive value was calculated. Fresh stock solution of permethrin (1mg/ml) in dimethyl sulphoxide and Tribulus terrestris (1mg/ml) in distilled water were prepared. Testicular tissues were cultured in TCM-199 nutrition media at 39℃ with 95% humidity and 5% CO₂ in the CO₂ incubator. Cultured testicular tissue was grouped as control having only the nutritive media, experimental group I(EI) received two doses of permethrin (100µg/ml and 200µg/ml), experimental group II(EII) was administered doses of permethrin along with vitamin C(0.1µM/ml) and experimental group III(EIII) was supplemented with doses of permethrin along with Tribulus terrestris (100µg/ml). All the groups were tested for 4 hr. and 8hr. for histoarcitectural studies.Results: Histological alterations were observed such as distorted shape of seminiferous tubules, decreased luminal and interstitial space, reduction in the population of spermatocytes, spermatozoa and spermatids in treated (E1) group as compared to control group. Maximum damage was detected at a higher dose of permethrin (200µg/ml) for 8h in contrast to lower doses (100 4h and 8h). Thus, it is concluded that permethrin has both dose and timedependent effects. Protective groups (E2 and E3) imparted ameliorative effects by reestablishing shape of seminiferous tubules, decreasing luminal and interstitial space, increased population of spermatocyte, spermatozoa, and spermatids as compared with treated groups (E1) Conclusion: It has been reported that permethrin affects male fertility by inducing detrimental changes in the structure and function of seminiferous tubules. Both vitamin C and TT have the ability to mitigate the effect of pesticide. TT shows aphrodisiac activity against permethrin induced alterations in goat testis.

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Histological effects of permethrin insecticide on the testis of adult wistar rats

Cited by 11 publications

References 16 publications

Effects of thiamethoxam and lambda‐cyhalothrin on spermatogenesis of Euschistus heros (Heteroptera: Pentatomidae)

Effects of thiamethoxam and lambda‐cyhalothrin on spermatogenesis of Euschistus heros (Heteroptera: Pentatomidae)

Current Research on the Safety of Pyrethroids Used as Insecticides

Ameliorative Effects of Phytoandrogen and Antioxidant on Histoarchitecture of Permethrin Induced Changes in Goat Testis

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