Histological Effects of Inhaled Corticosteroids and ß₂‐agonists on Laryngeal Mucosa in an Allergic Rat Model

Abstract

This study supported the presence of localized allergic reaction in the supraglottic laryngeal mucosa through the observation of increased mast cell number and degranulation. It was also shown that inhaled corticosteroids increase inflammation whereas combined inhaled corticosteroids and ß2-agonists minimize allergic and inflammatory reactions in supraglottic laryngeal mucosa providing a safer therapeutic option.