Histological effects of gold nanoparticles on lung tissue of adult male albino rats

Elbakary, Reda H.; Okasha, Ebtsam F.; Ragab, A. M.; Ragab, Mohamed Hassan

doi:10.1016/j.jmau.2017.08.002

Cited by 3 publications

(4 citation statements)

References 29 publications

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“…Besides, it was proved that intraperitoneal injection of 20 nm sized nanoparticles in rats for 3 days reduced the activity of the antioxidant reduced glutathione peroxidase [38]. This explanation is similar to that proposed by Elbakary et al to explain lung tissue damage induced by Au-NPs [20].…”

Section: Discussionsupporting

confidence: 80%

“…Prolonged inflammation leads to the release of more ROS, more cellular damage and apoptotic cell death [20]. In the adenohypophyseal sections of AU-NPs-treated rats, the detected cellular death was presumed to be due to mitochondrial (intrinsic) pathway of apoptosis, as it resulted from cellular stresses (oxidative and inflammatory) [31].…”

Section: Discussionmentioning

confidence: 99%

“…Group ІI (Au-NPs group): each rat was given a daily oral dose of Au-NPs (40 μg/kg/day) from the purchased solution in 1 ml sodium citrate, via a gastric tube for two weeks [20].…”

Section: Methodsmentioning

confidence: 99%

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Does repeated gold-nanoparticles administration affect pars distalis hormonal and folliculo-stellate cells in adult male albino rats?

Omar

Kamar

2021

Folia Histochem Cytobiol.

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Introduction. Worldwide, nanoparticles especially gold-nanoparticles (Au-NPs) are widely used in medicine, cancer treatment and cosmetic industry. They are easily conjugated with different biomedical and biological agents and effortlessly absorbed with few side effects.The pars distalis of the pituitary gland is considered as the maestro of the endocrine peripheral glands since it secrets trophic hormones that controls their functions. 5-10% of the non-granular pars distalis cells are folliculo-stellate cells (FSCs) that support the granular cells' functions. The aim of the study was to explore the histological and the biochemical effects of repeated exposure to Au-NPs on the pars distalis in adult male albino rats with highlighting the impact on FSCs.Material and methods. Thirty-six adult male albino rats were divided equally into control group and Au-NPs group (received 40 μg/kg/day of 11 ± 2 nm spherical Au-NPs orally for 2 weeks). Then, they were euthanized after 2 weeks and deposition of Au-NPs in pars distalis was investigated. Biochemical investigations and histological studies including hematoxylin and eosin staining, periodic acid Schiff's reaction, immunohistochemistry (IHC) for S-100, connexin 43 (Cx43) and Cytochrome-C (Cyt-C) as well as electron microscopic and morphometric studies were carried out. Results.The Au-NPs group demonstrated structural disorganization in the pars distalis, inflammation, congestion and increased extracellular PAS-positive colloid deposition due to the accumulation of Au-NPs. A significant increase in the immunoreactivity of S-100, Cx43 and Cyt-C, along with a significant increase in TNF-α, MDA, and bFGF content in the pituitary homogenates, was noted as compared to the control group. Ultrastructurally, degenerative changes were observed in the secretory cells. FSCs showed proliferation and increased phagocytic activity. Conclusions.Repetitive exposure of adult male albino rats to Au-NPs prompted the accumulation of these nanoparticles in the pars distalis that was accompanied by cellular degeneration and dysfunction of the secretory cell and proliferation of FSCs. Thus, monitoring of the pars distalis hormonal levels might be useful for early detection of some hazardous effects possibly associated with the use of gold-nanoparticles.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

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Does repeated gold-nanoparticles administration affect pars distalis hormonal and folliculo-stellate cells in adult male albino rats?

Omar

Kamar

2021

Folia Histochem Cytobiol.

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“…Decreases in AuNP size have been associated with more efficient deposition in the alveolar region of the lungs, increased potential for active uptake by alveolar epithelial cells, as well as enhanced potential for passive penetration of the air-blood barrier (757,1587,1588). In some instances, AuNP have been shown to contribute to compromised epithelial barrier integrity in the alveolar spaces, further promoting their entry into circulation and relocation to distal tissues (1589). AuNP surface modification and charge have been established as properties with significant potential to impact these processes (1590).…”

Section: Interactions Between Aunp and Various Biomolecules Can Resulmentioning

confidence: 99%

Metal Nanomaterials: Immune Effects and Implications of Physicochemical Properties on Sensitization, Elicitation, and Augmentation of Allergic Disease

Roach¹

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The recent surge in incorporation of engineered metallic and metal oxide nanomaterials into consumer products and their corresponding use in occupational settings has raised concerns over their potential to induce material size-specific toxicological effects. Although metal nanomaterials have been shown to induce greater degrees of lung injury and inflammation than their larger metal counterparts, their size-related effects on the immune system and allergic disease remain largely unknown. This knowledge gap is particularly concerning since metals are common inducers of allergic contact dermatitis, occupational asthma, and allergic adjuvancy.Overall, more scientific knowledge exists regarding the potential for metal-containing nanomaterials to exacerbate allergic disease than to their potential to induce allergic disease. Furthermore, effects of metal nanomaterial exposure on respiratory allergy have been more thoroughly-characterized than their potential influence on dermal allergy. Despite the existence of such knowledge, specific correlations between metal nanomaterial physico-chemical properties and their allergic effects have yet to be consistently demonstrated. As the number of emerging nanomaterials continues to increase, the delineation of these relationships has the potential to advance risk assessment efforts by helping to identify specific agents that may present an elevated risk for allergic effects.Two sets of studies were designed to begin addressing some of the knowledge gaps associated with the immunotoxic potential of metal nanomaterials in the context of allergic disease. The hypothesis of these studies was that nanomaterials comprised of metal constituents with known immunomodulatory potential augment, induce, and elicit allergic disease more readily than larger forms of the materials. Moreover, the nature of the immune responses caused by exposure to these metal nanomaterials, as well as the magnitude of the effects, correlates best with the parameter of dose surface area.The first set of studies incorporated NiO particles with different physico-chemical properties into an in vivo time course study and OVA asthma model. Results from the time course study demonstrated that the smaller NiO particles caused more pronounced pulmonary injury and inflammation, a discrepancy that could be mitigated by normalizing the administered particle dose to the surface area of the larger material. In the OVA model, augmentation of the allergic response was largely conserved with respect to NiO surface area, wherein larger doses caused polarization of pulmonary immune reposes towards a Th1/17-dominant state and smaller doses induced Th2-skewed responses. Despite this association, several immune markers, including total IgE production, BAL eosinophil number, and Penh response correlated better with other metrics, such as particle size.The second set of studies employed Au particles and nanoparticles to assess size-specific differences in allergenic potential. Neither particle was associated with potential for skin...

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WITHDRAWN: Anti-allergic activity of ethanol extractives of Quisqualis Indica Linn. by in-vitro compound 48/80 induced mast cell degranulation and in-vivo passive cutaneous anaphylaxis (PCA) model

Srivastava¹,

Chaudhary²,

Hemant³

et al. 2018

Toxicology Reports

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Histological effects of gold nanoparticles on lung tissue of adult male albino rats

Cited by 3 publications

References 29 publications

Does repeated gold-nanoparticles administration affect pars distalis hormonal and folliculo-stellate cells in adult male albino rats?

Does repeated gold-nanoparticles administration affect pars distalis hormonal and folliculo-stellate cells in adult male albino rats?

Metal Nanomaterials: Immune Effects and Implications of Physicochemical Properties on Sensitization, Elicitation, and Augmentation of Allergic Disease

WITHDRAWN: Anti-allergic activity of ethanol extractives of Quisqualis Indica Linn. by in-vitro compound 48/80 induced mast cell degranulation and in-vivo passive cutaneous anaphylaxis (PCA) model

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