Histological effect of Plantago lanceolata on different Mice Organs

Abstract

Medicinal plants, have been revealed and used in conventional therapy applies as primeval periods. Plants synthesized many chemicals to be act against insects, fungal infection, different diseases and bacteria. Where the singular plant comprises broadly diverse phytochemicals, but some time these effects may be uncertain. Plantago lanceolata one of the important medicinal plant due to numerous phytochemicals with potential pharmacological actions such as mucilage, glycosides, tannins, minerals such as silica, zinc, potassium etc. This study aimed to evaluate the capacity of P. lanceolate to modulate and counteract any damaged induced by methotrexate drug on testis and spleen of albino male mice for that four mice groups were used in study: group I, mice treated with 400 mg\kg of aqueous plant extract, group II, mice administrated with methotrexate drug at a dose of 40mg\kg group III an interaction group between drug and plant. The results indicated the P.laceolata to repair any abnormality and reduce the toxicity of drug and all these activity due to tannin, alkaloid, flavonoid and caffeic acid contents.

Anti-tumor Activity of Plantago lanceolata Aqueous Extract In Vitro and Genotoxicity by Micronucleus Assay In Vivo

“…Two doses of plant extract were given based on LC50 (half lethal concentration) to the plant, to albino female mice, the first dose being 250 mg/kg and the second increased to 500 mg\kg.LC50 of Plantago lanceolata 2,940 mg/kg [8].…”