Histological Effect and Protein Expression in Subthreshold TranspupillaryThermotherapy in Rabbit Eyes

Subthreshold transpupillary thermotherapy of the retina and experimental choroidal neovascularization in a rat model

“…At the lowest dose histological changes occurred mainly in the outer retinal layers, while at the highest dose, full-thickness retinal changes were observed. These findings are in accordance with Morimura et al's [19] results from rabbits and Connolly et al's [4] observations in humans. Connolly [4] found that even without observable ophthalmoscopic change there could be full-thickness retinal alterations in a more pigmented human eye.…”

“…This means as long as we cannot individualize the TTT parameters, there is a possibility of damaging the retina. Morimura et al's [19] histopathologic findings in rabbits were more like those in the lowest dose group in our study. This may be due to the differences between species and to different laser parameters.…”

“…Morimura et al [19] found hsp70 expression in rabbit retina 4 weeks after subthreshold TTT but none in the choroid. Desmettre et al [6] reported that 1 day after subthreshold TTT in rabbits, Hsp70 was only expressed in the choroid.…”

Transpupillary thermotherapy for subfoveal leaks in central serous chorioretinopathy

“…26 An animal study showed that even clinically subthreshold TTT could damage the neural retina. 29 Indeed, macular burn and visual loss has been reported after TTT for CNV. 30 However, in CSC, subretinal fluid probably protects the retina from thermal damage.…”

“…30 However, in CSC, subretinal fluid probably protects the retina from thermal damage. 26,27,29 Further, subretinal pigmented lesions or blood, which accentuate neural retinal damage, 27,28 are absent in CSC. Therefore, it is possible that TTT may be relatively safer in CSC as compared to other exudative submacular pathologies.…”