Histological differentiation of metastatic renal carcinoma in the cerebellum from cerebellar haemangioblastoma in von Hippel-Lindau's disease.

Clelland, Colin; Treip, C. S.

doi:10.1136/jnnp.52.2.162

Cited by 28 publications

(10 citation statements)

References 4 publications

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“…Since high vascularization and clear cell morphology are common to both tumor types, these features sometimes cause differential diagnostic problems between hemangioblastoma and brain metastasis of clear cell renal carcinoma 4,5,9 9 and reticulin‐silver staining highlights these patterns 12 . However, hemangioblastomas with prominent proliferations of stromal cells occasionally display well‐defined lobules, and it is hard to distinguish them from metastatic clear cell carcinoma by light microscopy alone 11…”

Section: Discussionmentioning

confidence: 99%

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Metastasis of renal cell carcinoma to central nervous system hemangioblastoma in two patients with von Hippel–Lindau disease

Hamazaki

Nakashima²,

Matsumoto³

et al. 2001

Pathology International

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Here we report tumor-to-tumor metastases identified in two patients with von Hippel-Lindau (VHL) disease. The first patient had bilateral renal carcinomas and multiple cerebellar hemangioblastomas, and the second patient had a renal carcinoma and multiple hemangioblastomas in the retina, cerebellum and spinal cord. A cerebellar lesion from the first patient and a spinal lesion from the second patient contained two distinct components. The inner part of these tumors consisted of a nested mass of polygonal clear cells that expressed cytokeratin and epithelial membrane antigen, while the outer part of the tumors showed proliferation of capillaries and intervening foamy stromal cells that were negative for cytokeratin and epithelial membrane antigen. The tumors were thus considered to be hemangioblastomas complicated by metastatic lesions of renal cell carcinoma of clear cell type. These cases indicate that tumor-to-tumor metastasis should be considered when hemangioblastoma contains a clear cell carcinoma component in the setting of VHL disease, and that immunohistochemical staining for cytokeratin and epithelial membrane antigen is useful for the diagnosis.

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Section: Discussionmentioning

confidence: 99%

“…Immunohistochemical staining for EMA and cytokeratin facilitates the differentiation of hemangioblastoma and metastatic clear cell tumor, as hemangioblastomas are negative for these epithelial markers 4,5,10–13 …”

Section: Discussionmentioning

confidence: 99%

Metastasis of renal cell carcinoma to central nervous system hemangioblastoma in two patients with von Hippel–Lindau disease

Hamazaki

Nakashima²,

Matsumoto³

et al. 2001

Pathology International

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“…Pancreatic neuroendocrine tumors associated with von HippelLindau disease are very rare in contrast to pheochromocytoma. Only eleven cases of von Hippel-Lindau disease with neuroendocrine tumors of the pancreas (listed in Table 1) have been reported in the literatures (1,(9)(10)(11)(12)(13)(14)(15)(16)(17). Amongthem, three cases have functioning tumors producing insulin, glucagon, pancreatic polypeptide, vasoactive intestinal peptide (VIP), and/or calcitonin (1 1, 13, 14).…”

Section: Discussionmentioning

confidence: 99%

Somatostatinoma of the Pancreas Associated with von Hippel-Lindau Disease.

et al. 1995

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A 39-year-old manwas admitted because of lumbago, vomiting and massive gastrointestinal bleeding. Oliguria developed a few days later, which was followed by hyperkalemia and cardiac arrest. Autopsy disclosed multiple renal cell carcinomas with diffuse metastasis to the liver, adrenal gland, psoas muscle and vertebrae. In addition, a somatostatinoma wasfound in the pancreas. From these findings and past history of cerebellar hemangioblastoma and spinal hemangioma he was diagnosed to have von Hippel-Lindau disease. Von Hippel-Lindau disease with islet cell tumor is very rare and is reported here with a review of literature. (Internal Medicine 34: 661-665, 1995)

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“…Moreover, immunohistochemical staining did not detect EMA and VHL-gene mutations were absent in DNA extractions from tumour cells. 11 The pathophysiology of late brain metastasis is still unclear. Apparently, our patient harboured a slow growing, low grade variant of renal cell carcinoma as indicated by a low mitotic index and non-invasive behaviour with respect to the surrounding brain tissue.…”

Section: Discussionmentioning

confidence: 99%

Single cerebral metastasis 3 and 19 years after primary renal cell carcinoma: case report and review of the literature

Röser

Rosahl

Samii

2002

Journal of Neurology, Neurosurgery &Amp; Psychiatry

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Histological differentiation of metastatic renal carcinoma in the cerebellum from cerebellar haemangioblastoma in von Hippel-Lindau's disease.

Cited by 28 publications

References 4 publications

Metastasis of renal cell carcinoma to central nervous system hemangioblastoma in two patients with von Hippel–Lindau disease

Metastasis of renal cell carcinoma to central nervous system hemangioblastoma in two patients with von Hippel–Lindau disease

Somatostatinoma of the Pancreas Associated with von Hippel-Lindau Disease.

Single cerebral metastasis 3 and 19 years after primary renal cell carcinoma: case report and review of the literature

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