Histological diagnosis of Burkitt's lymphoma: a cautionary tale.

Bluming, A Z; Templeton, A. C.

doi:10.1136/bmj.1.5740.89

Cited by 6 publications

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“…Autopsiematerial ist g/inzlich ungeeignet. Wird die Gefrierschnitt-Technik angewandt, kann h6chstens die Diagnose eines malignen Lyrephotos ausgeschlossen werden [6], da sie mit mannigfachen Artefakten behaftet ist. Die Prfiparate sollten lufttrocknen und langsam fiber 7-10 Tage in HgC1-Formalin fixiert werden [10], Am besten hat sich die Romanovsky-F/irbung bew/ihrt [33].…”

Section: Kiel Klaesifikatienunclassified

Das Burkitt-like Lymphom: Differentialdiagnose, Klinik und Therapie

1979

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The Burkitt-like lymphoma is extremely rare. It shows a predominance of presentation in abdominal and pelvic sites and an older median age as compared to the endemic Burkitt's lymphoma. Both are independent prognostic determinants and reflect a poor prognosis. This might be the reason for the low response rate to cytotoxic treatment. Cyclophosphamide is a substantial part of any chemotherapeutic regimen used. Serum lactic dehydrogenase (LDH) levels are closely correlated with the extent of tumor mass and the response to therapy. Chemotherapy might be associated with serious metabolic complications including hyperkalemia, lactic acidosis, anuria, and sudden death from lethal embolization of the lung. In contrast to Burkitt's lymphoma, the Burkitt-like tumor has no association with the Epstein-Barr-virus. In both lymphomas a translocation from the 8q onto 14q chromosome occurs being a characteristic marker for these malignancies.

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Section: Kiel Klaesifikatienunclassified

Das Burkitt-like Lymphom: Differentialdiagnose, Klinik und Therapie

1979

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A comparison of clinical and histopathologic features of childhood malignant lymphoma in Uganda

Magrath

Ziegler

Templeton

1974

Cancer

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One‐hundred seventy‐two Ugandan children with lymphoma have been studied with a view to determining the value of morphology (histology and cytology) as a means of predicting clinical behavior and response to treatment. In the group where a morphological diagnosis of BL was made (147), duration of symptoms was shorter than in the other groups; 85% of patients had a tumor distribution considered to be typical of BL (jaws, orbits, intra‐abdominal, epidural, meningeal, or cranial nerve tumor). In the HL group (11), no patient had a tumor distribution typical of BL, while in the LL g4roup (14), 8 patients might have been considered to be BL on clinical grounds alone. Response to cyclophosphamide therapy was complete in 92% of the BL group, 27% of the LL group, and none of the HL group. Survival was significantly better in patients with BL (65% long term remission) than in the other groups (median survival 28 weeks). Anti‐VCA titers were invariably raised in the BL group, and sometimes raised in the other groups. We confirm that BL is a separate clinical entity and can in the majority of cases be clearly distinguished from other types of lymphoma on morphological grounds alone. In individual cases where difficulty in making a diagnosis arises, there is no final arbiter. We must await the development of more sophisticated techniques of biochemical, immunologic, and etiologic classification of tumors.

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