Histological Characteristics of Mesothelioma Associated With Asbestos*

Churg, Jacob; Rosen, Samuel H.; Moolten, Sylvan E.

doi:10.1111/j.1749-6632.1965.tb41141.x

Cited by 77 publications

(6 citation statements)

References 6 publications

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“…McCaughey (1958) was rather guarded on the subject mentioning metastases to lung and liver but regarding more distant spread as unusual, though not in itself a reason for changing the diagnosis. In other accounts (Churg, Rosen and Moolten, 1965;Hourihane, 1964;Payling Wright and Heard, 1966) the infrequence of distant metastases has been emphasized, so much so that when these have been present the diagnosis has been regarded as uncertain or even been rejected. Evans (1966) summarizes a commonly held view when he says 'at the present stage of our knowledge of these tumours the diagnosis in such cases is open to question since the distinction from other widely metastasizing neoplasms is difficult'.…”

Section: Chest Wall Operation Site and Diaphragmmentioning

confidence: 99%

Diffuse malignant pleural mesothelioma and asbestos exposure

Whitwell¹,

Rawcliffe²

1971

Thorax

157

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Pleural mesothelioma has been diagnosed in 52 patients in three hospitals on Merseyside between 1955 and 1970, 60% being diagnosed from operation specimens and the rest from postmortem tissues. Necropsies eventually held on nearly half the operation cases confirmed the diagnosis, giving a necropsy rate of 70% for the series. The morbid anatomy conformed to earlier descriptions except that widespread metastases were much commoner than has usually been described. Histological findings agreed with previous accounts of the tumour, except that, in our hands, special acid mucopolysaccharide staining was less reliable than Southgate's mucicarmine, which was of value in differential diagnosis. Association with asbestos was confirmed from industrial histories in 80% of cases, the commonest industries involved being shipbuilding and repairing in men and sackware repairing in women. Lungs of industrial mesothelioma cases showed basal asbestosis in 17% and excessive asbestos bodies in almost all the rest. Quantitative comparison of asbestos bodies in lung smears from mesothelioma cases compared with lung smears from other Merseyside adults showed much higher counts in the mesothelioma cases. The interval from first exposure to asbestos until appearance of mesothelioma ranged between 13 and 63 years, with a mean of 42 years. We think the incidence of mesothelioma will continue to rise with the increased use of asbestos until about 40 years after adequate protective measures have been taken.

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Section: Chest Wall Operation Site and Diaphragmmentioning

confidence: 99%

Diffuse malignant pleural mesothelioma and asbestos exposure

Whitwell¹,

Rawcliffe²

1971

Thorax

157

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“…The tumours were relatively homogeneous in histological appearance, in contrast to the pleomorphism which has been described in mesotheliomas from other experimental animals (Wagner et al, 1962;Smith ef al., 19656) and also in man (McCaughey, 1958(McCaughey, , 1965Churg et al, 1965). Secondly, many of them were infiltrated with chronic inflammatory cells.…”

Section: Discussionmentioning

confidence: 96%

The pathological effects of subcutaneous injections of asbestos fibres in mice: Migration of fibres to submesothelial tissues and induction of mesotheliomata

Roe

Carter

Walters

et al. 1967

Intl Journal of Cancer

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“…It was reported that confidence in the diagnosis of diffuse mesothelioma during an autopsy rested on the ability to exclude other tumors (McCaughey 1965). In one report, however, 30 cases of mesothelioma were studied histopathologically (Churg et al 1965). The association of the mesothelioma occurrence to asbestos exposure has been suggested (Hourihane 1965;Vigliani et al 1965;McDonald et al 1970), and it is reported that the elevated level of acid mucopolysaccharide in serous effusion may be useful for the diagnosis of mesothelioma (Thompson et al 1969).…”

Section: Discussionmentioning

confidence: 99%