Histological changes of the skin during postembryonic development of the crested newt Triturus ivanbureschi (Urodela, Salamandridae)

Ajduković, Maja; Ukropina, Mirela; Cvijanović, Milena; Vučić, Tijana; Ivanović, Ana

doi:10.1016/j.aanat.2023.152097

Cited by 2 publications

(2 citation statements)

References 43 publications

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“…It regulates the entry of microorganisms, maintains the body temperature, and controls the physiological water levels. Comprising three layers of biological tissues with distinct architecture and functionality-epidermis, dermis, and hypodermis-the skin plays a crucial role in overall health [45][46][47][48].…”

Section: Skin and Topical Delivery Of Liposomesmentioning

confidence: 99%

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Beyond Traditional Sunscreens: A Review of Liposomal-Based Systems for Photoprotection

Miranda,

Cruz,

Girão

et al. 2024

Pharmaceutics

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Sunscreen products are essential for shielding the skin from ultraviolet (UV) radiation, a leading cause of skin cancer. While existing products serve this purpose, there is a growing need to enhance their efficacy while minimizing potential systemic absorption of UV filters and associated toxicological risks. Liposomal-based formulations have emerged as a promising approach to address these challenges and develop advanced photoprotective products. These vesicular systems offer versatility in carrying both hydrophilic and lipophilic UV filters, enabling the creation of broad-spectrum sunscreens. Moreover, their composition based on phospholipids, resembling that of the stratum corneum, facilitates adherence to the skin’s surface layers, thereby improving photoprotective efficacy. The research discussed in this review underscores the significant advantages of liposomes in photoprotection, including their ability to limit the systemic absorption of UV filters, enhance formulation stability, and augment photoprotective effects. However, despite these benefits, there remains a notable gap between the potential of liposomal systems and their utilization in sunscreen development. Consequently, this review emphasizes the importance of leveraging liposomes and related vesicular systems as innovative tools for crafting novel and more efficient photoprotective formulations.

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Section: Skin and Topical Delivery Of Liposomesmentioning

confidence: 99%

“…The hypodermis, the innermost layer, primarily consists of adipocytes, fibroblasts, and macrophages. It functions to protect against shock, conducting nerve signals, provide thermal insulation, and serve as the body's energy reserve [48,52,53].…”

Section: Skin and Topical Delivery Of Liposomesmentioning

confidence: 99%

Beyond Traditional Sunscreens: A Review of Liposomal-Based Systems for Photoprotection

Miranda,

Cruz,

Girão

et al. 2024

Pharmaceutics

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Loss of the ability to regenerate body appendages in vertebrates: from side effects of evolutionary innovations to gene loss

Zaraisky,

Araslanova,

Shitikov

et al. 2024

Biological Reviews

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The ability to regenerate large body appendages is an ancestral trait of vertebrates, which varies across different animal groups. While anamniotes (fish and amphibians) commonly possess this ability, it is notably restricted in amniotes (reptiles, birds, and mammals). In this review, we explore the factors contributing to the loss of regenerative capabilities in amniotes. First, we analyse the potential negative impacts on appendage regeneration caused by four evolutionary innovations: advanced immunity, skin keratinization, whole‐body endothermy, and increased body size. These innovations emerged as amniotes transitioned to terrestrial habitats and were correlated with a decline in regeneration capability. Second, we examine the role played by the loss of regeneration‐related enhancers and genes initiated by these innovations in the fixation of an inability to regenerate body appendages at the genomic level. We propose that following the cessation of regenerative capacity, the loss of highly specific regeneration enhancers could represent an evolutionarily neutral event. Consequently, the loss of such enhancers might promptly follow the suppression of regeneration as a side effect of evolutionary innovations. By contrast, the loss of regeneration‐related genes, due to their pleiotropic functions, would only take place if such loss was accompanied by additional evolutionary innovations that compensated for the loss of pleiotropic functions unrelated to regeneration, which would remain even after participation of these genes in regeneration was lost. Through a review of the literature, we provide evidence that, in many cases, the loss in amniotes of genes associated with body appendage regeneration in anamniotes was significantly delayed relative to the time when regenerative capability was lost. We hypothesise that this delay may be attributed to the necessity for evolutionary restructuring of developmental mechanisms to create conditions where the loss of these genes was a beneficial innovation for the organism. Experimental investigation of the downregulation of genes involved in the regeneration of body appendages in anamniotes but absent in amniotes offers a promising avenue to uncover evolutionary innovations that emerged from the loss of these genes. We propose that the vast majority of regeneration‐related genes lost in amniotes (about 150 in humans) may be involved in regulating the early stages of limb and tail regeneration in anamniotes. Disruption of this stage, rather than the late stage, may not interfere with the mechanisms of limb and tail bud development during embryogenesis, as these mechanisms share similarities with those operating in the late stage of regeneration. Consequently, the most promising approach to restoring regeneration in humans may involve creating analogs of embryonic limb buds using stem cell‐based tissue‐engineering methods, followed by their transfer to the amputation stump. Due to the loss of many genes required specifically during the early stage of regeneration, this approach may be more effective than attempting to induce both early and late stages of regeneration directly in the stump itself.

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Histological changes of the skin during postembryonic development of the crested newt Triturus ivanbureschi (Urodela, Salamandridae)

Cited by 2 publications

References 43 publications

Beyond Traditional Sunscreens: A Review of Liposomal-Based Systems for Photoprotection

Beyond Traditional Sunscreens: A Review of Liposomal-Based Systems for Photoprotection

Loss of the ability to regenerate body appendages in vertebrates: from side effects of evolutionary innovations to gene loss

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