Histological Changes of the Feline Cervix, Endometrium and Placenta after Mid‐gestational Termination of Pregnancy with Aglepristone

Georgiev, Plamen; Wehrend, Axel; Penchev, G.; Vodenicharov, A.; Kauffold, Johannes; Leiser, Rudolf

doi:10.1111/j.1439-0531.2007.00927.x

Cited by 13 publications

(12 citation statements)

References 24 publications

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“…On the contrary, ALI was effective at inducing abortion in queens at days 21–22 of pregnancy. Whereas previous reports have shown that ALI was effective in the queen to terminate pregnancy on days 25–26 without side effects (Georgiev and Wehrend , ), to our knowledge, this is the first study to report the lack of efficacy of CLO to induce abortion in the queen. Previous studies using of PGF in cat at 21–25 days of a pseudopregnancy depressed luteal function, but did not induce complete luteolysis (Shille and Stabenfeldt ).…”

Section: Discussionmentioning

confidence: 52%

Efficacy of Cloprostenol or Aglepristone at 21–22 and 35–38 Days of Gestation for Pregnancy Termination in Queens

Mitacek

Stornelli

Praderio

et al. 2012

Reprod Domestic Animals

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ContentsThe objective of this study was to evaluate the efficacy of cloprostenol (CLO) or aglepristone (ALI) for pregnancy termination in queens at 21-22 and 35-38 days of gestation. Two experiments (EXP) were carried out to accomplish this aim. Thirty-seven 12-to 14-month-old mixed breed queens were used in a randomized design. At oestrus, queens were housed for mating with a tom, and pregnancy was confirmed by transabdominal ultrasonographic examination (US). On days 21-22 of pregnancy (EXP1) or 35-38 of pregnancy (EXP2), queens were divided into three groups (G). Queens in G1 received ALI (10 mg/kg, sc; EXP1, n = 6; EXP2, n = 6) on two consecutive days. Queens in G2 received CLO (5 lg/kg, sc; EXP1, n = 6; EXP2 = 7) on three consecutive days. Queens in G3 received 1 ml of saline solution (PLA, sc; EXP1, n = 6; EXP2 = 6). After treatment, females were monitored daily by US during for 10 days and weekly until the end of gestation. In EXP1, pregnancy was terminated in (6/6, 100%), (0/6, 0%) and (0/6, 0%), for the ALI, CLO and PLA groups, respectively (p < 0.001). In EXP2, pregnancy was terminated in (6/6, 100%), (1/7, 14%) and (0/6, 0%) for the ALI, CLO and PLA groups, respectively (p < 0.001). In both EXP, after CLO administration, animals vomited and were depressed for 30 min; but no side effects were observed in the animals in the ALI group. In conclusion, the results from this study indicate that three injections of CLO are not effective, but two injections of ALI are effective to induce abortion in queens at 21-22 or 35-38 days of pregnancy. IntroductionTermination of unwanted pregnancies in the queen can be achieved using cabergoline alone or in combination with prostaglandin F 2a (PGF;Onclin and Verstegen 1997;Eru¨nal-Maral et al. 2004). Previous studies have shown that multiple doses of PGF in cats from day 21 to day 25 of pseudopregnancy depressed luteal function, but did not produced complete luteolysis of the corpus luteum (Shille and Stabenfeldt 1979). Prostaglandins have been proved effective to induce abortion in queens with more than 40 days of gestation, but failed to induce abortion in queens with <40 days of pregnancy (Nachreiner and Marple 1974). It is not clear whether the effect of PGF in these animals was the result of direct abortifacient action on the uterus or because of luteolysis of the corpora lutea of pregnancy. It is possible that abortions occurred because of a direct contractile effect on the uterus in the presence of depressed luteal function, but complete luteolysis did not happen (Shille and Stabenfeldt 1979). Furthermore, when PGF was administered at 45 days of gestation, a higher percentage of abortion was obtained compared when it was used at day 30 of gestation. All cats had decreasing P 4 concentrations during treatment, but only queens with abortion showed P 4 levels <1 ng/ml (Baldwin et al. 2000). In addition, PGF administration at day 33 of pregnancy induces luteolysis and pregnancy termination with expulsion of foetuses (Verstegen et al. 1993). Furthermore, PGF and clop...

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Section: Discussionmentioning

confidence: 52%

Efficacy of Cloprostenol or Aglepristone at 21–22 and 35–38 Days of Gestation for Pregnancy Termination in Queens

Mitacek

Stornelli

Praderio

et al. 2012

Reprod Domestic Animals

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“…2 is also known from literature (Berman 1974;Johnston et al 2001a). Besides Georgiev et al (2008) histologically observed bleedings at the paraplacenta and the placental girdle, within the uterine lumen and the interstitial mucosal stroma of the cervix following induction of abortion with aglepristone on days 25 ⁄ 26.…”

Section: Discussionmentioning

confidence: 97%

Induction of Abortion with Aglepristone in Cats on Day 45 and 46 After Mating

Georgiev

Bostedt

Goericke-Pesch

et al. 2009

Reproduction in Domestic Animals

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The aim of this study was to test for the efficacy and safety of the use of aglepristone for pregnancy termination on day 45 in cats. Six healthy cats were treated with 10 mg/kg aglepristone sc on day 45 and 46 after mating; six other cats served as untreated controls. The effect of treatment was monitored by general examination, vaginal cytology, ultrasonography and blood sampling for haematology and progesterone determination. Besides, interoestrus interval and next pregnancy including litter size were recorded. The efficacy of treatment was approximately 67% (4/6) with abortion occurring 4-7 days after the first injection and a sanguineous discharge and erythrocytes in vaginal smears for at least 6 days afterwards. The two treated cats that did not abort gave birth to two kittens on day 67 and had a stillbirth of a single kitten on day 71, respectively. As expected enlargement of the mammary glands and lactation were observed in all treated cats. No other treatment-induced side effects were observed. Progesterone levels at abortion were high (30-140 nmol/l), but were decreased on day 55. Aglepristone treatment did not affect fertility in following cycles. Finally, it can be concluded that late-term pregnancy termination with aglepristone is possible but due to a success rate of 67% an ultrasonographical examination 7 days after treatment is an inherent necessity to control the effect of treatment.

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“…Another alternative to induce abortion is the use of antiprogestins, such as aglepristone (ALI). Treatment with ALI has been proven to be safe and effective for early, middle, and late pregnancy termination in the queen [6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Progesterone and ultrasonographic changes during aglepristone or cloprosternol treatment in queens at 21 to 22 or 35 to 38 days of pregnancy

et al. 2017

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Progesterone (P) is a requirement for pregnancy development. Previous reports observed a maximal value of serum P concentration on 21 days after the first mating after which it slowly declines throughout the rest of pregnancy. Ultrasound examination should be performed to ensure that pregnancy interruption is complete. Limited information is available on the ultrasonic appearance of conceptuses during pregnancy termination in cats The objective was to study serum P concentration and ultrasonographic changes during aglepristone (ALI) or cloprostenol (CLO) treatment and to evaluate the fertility after treatment. Two experiments (EXP) were carried out to accomplish this aim. Sixty queens, 12- to 36-month-old, were used. On Days 21 to 22 of pregnancy (EXP I) or 35 to 38 of pregnancy (EXP II), queens were divided into three groups (G). Queens in G1 received ALI (10 mg/kg, sc; EXP I, n = 10; EXP II, n = 10) for 2 consecutive days. Queens in G2 received CLO (5 μg/kg, sc; EXP I, n = 10; EXP II = 10) for 3 consecutive days. Queens in G3 received 1 mL of saline solution (PLA, sc; EXP I, n = 10; EXP II = 10). Blood samples were taken before treatment (Day 0) and every day during 10 days after the treatment to measure serum P concentrations. Likewise, after treatment, queens were monitored daily by ultrasonography for 10 days and weekly until the end of gestation to obtain gestational sacs measurements (GS), fetal measurements, and fetal biophysical profile. Data were analyzed by ANOVA. Serum P concentrations were significantly different on Day 6 (EXP I) and on Day 1 (EXP II) in ALI and CLO groups compared with PLA group (P < 0.05 and P < 0.01; respectively). The ultrasonographic monitoring during treatment allowed assessing changes in the GS and fetal measurements, embryo-fetal viability, and risk of pregnancy loss. In conclusion, the results from this study reported changes in serum P concentration and in ultrasonography measurements during pregnancy interruption with ALI or CLO treatment. Also it was observed that ALI and CLO are safe drugs and can preserve posttreatment queen fertility. Therefore, the results obtained in our work will be applied in feline reproduction practice.

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Histological Changes of the Feline Cervix, Endometrium and Placenta after Mid‐gestational Termination of Pregnancy with Aglepristone

Cited by 13 publications

References 24 publications

Efficacy of Cloprostenol or Aglepristone at 21–22 and 35–38 Days of Gestation for Pregnancy Termination in Queens

Efficacy of Cloprostenol or Aglepristone at 21–22 and 35–38 Days of Gestation for Pregnancy Termination in Queens

Induction of Abortion with Aglepristone in Cats on Day 45 and 46 After Mating

Progesterone and ultrasonographic changes during aglepristone or cloprosternol treatment in queens at 21 to 22 or 35 to 38 days of pregnancy

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