Histological changes of female reproductive organs subjected to different jumping exercise intensities and honey supplementation in rats

Mosavat, Maryam; Mohamed, Mahaneem; Ooi, Foong Kiew; Mirsanjari, Mitra; Zin, Anani Aila Mat; Romli, Aminah Che

doi:10.7717/peerj.7646

Cited by 5 publications

(3 citation statements)

References 25 publications

(43 reference statements)

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“…In addition, the FST procedure proved to be positively correlated with hepatic TNF-α production, following other studies that prove that physical stress can increase TNF-α expression in the liver [28]. The antioxidant content of honey is known to suppress cell damage due to physical stress and ROS [29,30]. Furthermore, honey has also been shown to increase the production of endogenous hepatic antioxidants SOD as well as GPx, GSH, and catalase [22,23].…”

Section: Resultssupporting

confidence: 56%

Untitled

2023

J. Med. Chem. Sci.

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Physical activity in general improves metabolic processes by stimulating muscles to contract actively, improving blood circulation, and supplying oxygen. On the other hand, it will create stressful conditions, which will increase cell damage and inflammatory responses in the liver. This study aimed to determine the effect of forest bee honey supplementation on the expression of HIF-1α, SOD, and TNF-α in rats that underwent the forced swimming test (FST) as a physical stress model. The physical activity conducted is at risk of disrupting to several organs due to the stress it causes in addition to the obtained health benefits. A total of 24 adult female rats were divided into four groups: Control (C) with FST only, (T1) FST and honey 2 g/day, (T2) FST and honey 4 g/day, (T3) FST and honey 6 g/day. A forced swimming test was conducted for five minutes per day for 14 days. The collected liver organs were histopathologically prepared by immunohistochemical staining for HIF-1α, SOD, and TNF-α proteins. The results showed that hepatic HIF-1α and TNF-α expression decreased in the honey-supplemented group, while hepatic SOD expression increased, although all three showed insignificant differences from each other. This study concludes that honey supplementation is incapable of increasing the expression of SOD as well as reducing the expression of HIF-1α and TNF-α in the liver of rats modelled by physical stress.

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Section: Resultssupporting

confidence: 56%

Untitled

2023

J. Med. Chem. Sci.

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“…It is made up as a result of regurgitation and evaporation of oral nectar by honeybees (Pipicelli et al, 2009). Honey consists of avonoids, antioxidants, organic acid, minerals, protein, vitamins and carbohydrates such as fructose, sucrose, ra nose and glucose (Mosavat et al, 2019). These chemical constituents had made honey, a well-known antibacterial, antimicrobial and antifungal agent (Aswin and Neelusree, 2019).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of sex steroid hormones and reproductive irregularities in diethyl phthalate-exposed premature mice: modulatory effect of raw honey against potential anomalies

Ara

Asmatullah

Yaseen

et al. 2021

Environ Sci Pollut Res

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Phthalates, plasticizing chemicals are top-rated environmental contaminants. Diethyl phthalate (DEP), a chief member of this family was declared a potent endocrine-disruptor and carcinogen in animals and humans. The current study was designed to explore the probable reproductive damage induced by DEP and the therapeutic e cacy of raw honey in male albino mice. Four weeks old 50 male mice, were randomized equally in ve groups, as control (C) received 0.1 ml distilled water; vehicle control (VC) received 0.1 ml corn oil; DEP (3mg/g/BW) dissolved in corn oil; Honey control (HC) administered 0.2 mg/g/day); P + H administered with DEP and honey (3mg and 0.2 mg/g/BW/day respectively). Mice were treated through oral gavage for 54 days routinely, acclimatized for 6 days and dissected. In the rst instance, the antioxidant potential and total phenolic contents of honey were analyzed through Ferric reducing antioxidant power assay and Folin-Ciocalteu assay to con rm the antioxidant capacity of honey. The morphological, morphometric, histological, micrometric, sperm count, hormonal analyses, and antioxidant capacity test in tissue homogenates were conducted by using tissues (testis, epididymis) and blood samples of mice. Mice exposed to DEP have a signi cant increase in body weight, LH level, seminiferous tubule lumen diameter and decrease in the gonado-somatic index, testosterone level, sperm count, and seminiferous tubule diameter. Additionally, histopathology of testes showed interstitial spaces dilations, exfoliations, Leydig cells atrophy, germ cell degenerations and spermatid retention in DEP exposed testes sections. However, concomitant use of honey and DEP had shown a signi cant improvement in histopathological lesions, steroid hormone levels, and healthy sperm count. By these results, it is concluded that honey possessed antioxidant potential that can e ciently protect DEPinduced anomalies in male mice.

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“…These disruptions could result in an irregular menstrual cycle, including luteal phase deficit and anovulation. Further research is needed to determine which therapies might be effective in reducing or preventing the negative effects of extended and high-intensity exercise on female athletes' reproductive health [98].…”

Section: Menstrual Dysfunction From Low Energy Availability In Athlet...mentioning

confidence: 99%

Menstrual cycle changes among female athletes post a traumatic brain injury: A systematic review

Yussuf Abuelhaija,

Motasem Alzaqh,

Haneen A. Al-Bataineh

et al. 2023

World J. Adv. Res. Rev.

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Introduction: Traumatic brain injury (TBI) commonly affects athletes and can lead to menstrual cycle changes in female athletes. This review highlights the existing literature on menstrual cycle changes post-TBI. TBI disrupts the hormonal regulation of the menstrual cycle, causing irregular or absent periods, hormonal imbalances, and related symptoms. These changes impact the physical and psychological well-being of athletes during recovery. However, research in this area is limited, necessitating further investigation into the mechanisms and implications of menstrual cycle changes in female athletes post-TBI. Healthcare providers and sports medicine professionals must be aware of these effects and provide appropriate care and support. Prioritizing overall health and well-being, including menstrual health, is crucial for female athletes post-TBI. This involves nutrition, stress management, and adjustments to training and competition schedules as necessary. Raising awareness and educating athletes, coaches, and stakeholders is vital for proper care and support. Additional research on menstrual cycle changes in female athletes post-TBI will inform clinical practice and enhance the health and performance outcomes of female athletes. Methods: A comprehensive literature search was conducted using databases including PubMed, Embase, Scopus, Web of Science, and SPORTDiscus. The search strategy employed relevant keywords and MeSH terms to identify observational and experimental studies published from the inception of each database until the present day. Inclusion criteria encompassed studies involving female athletes diagnosed with a concussion, assessing the physiological or pathological changes during the menstrual cycle, and reporting data on hormone fluctuations, symptomatology, cognitive function, mood, neuroimaging, or biomarkers. Independent reviewers screened articles, extracted data, and resolved disagreements through consensus. Results: The initial search yielded 500 articles, and after applying inclusion criteria, 108 studies were included. Menstrual cycle disruptions were assessed through self-reporting and hormonal analysis. Findings indicated potential links between sports-related concussions and irregularities in cycle length, alterations in hormone levels, and changes in menstrual symptoms. However, heterogeneity among the studies and lack of standardized methodologies limited definitive conclusions. Conclusion: This systematic review underscores the need for further research to elucidate the relationship between sports-related concussions and menstrual cycle disturbances in female soccer players. Future studies should employ standardized methodologies, including objective measures and larger sample sizes. Understanding the impact of concussions on the menstrual cycle is vital for holistic care and optimal performance of female athletes in contact sports. Identifying underlying mechanisms will facilitate the development of targeted interventions and preventive strategies to ensure long-term reproductive health and overall well-being after head injuries in female soccer players.

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Histological changes of female reproductive organs subjected to different jumping exercise intensities and honey supplementation in rats

Cited by 5 publications

References 25 publications

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Evaluation of sex steroid hormones and reproductive irregularities in diethyl phthalate-exposed premature mice: modulatory effect of raw honey against potential anomalies

Menstrual cycle changes among female athletes post a traumatic brain injury: A systematic review

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