Histological Changes in the Liver in Diseases of the Biliary Tract

Falkmer, Sture; Sjöström, Bo

doi:10.1159/000202945

Cited by 9 publications

(3 citation statements)

References 16 publications

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“…[3] found focal necrosis in 11 per cent of the specimens taken al the beginning of tin' operation and in 34 per cent of those taken at its end. Falliiiipr and Sjostriim [6] encountered similar lesions in 26 per cent of 211 liver specimens excised al the beginning of operations for biliary tract diseases.…”

Section: By H Sunzel and L Zettergrenmentioning

confidence: 88%

“…(i) a subcapsular zone of necrobiotic or necrotic liver cells infiltrated by granulocytes [4,5,8] and (ii) leukocyte infiltration into deep single or multiple liver cells [3,4,5,6,7,8]. According to some workers the leukocytic infiltration into the liver cells is combined w ith necrosis [4,5]; other deny this [8], However this lesion has often been called focal necrosis.…”

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confidence: 99%

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Histological Liver Lesions Developing during Abdominal Operations

Sunzel¹,

Zettergren²

1966

Digestion

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Section: By H Sunzel and L Zettergrenmentioning

confidence: 88%

mentioning

confidence: 99%

Histological Liver Lesions Developing during Abdominal Operations

Sunzel¹,

Zettergren²

1966

Digestion

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“…4 The debate surrounding the incidence rates of hepatocellular damage in individuals with gall stone disease has persisted for many years. 5 In 1918, Graham was the first to recognize the potential impact of gallstone disease on the liver, emphasizing the need for thorough evaluation. 6 Building on this foundation, Orloff et al conducted pioneering and seminal research between 1942 and 1948, marking a significant milestone in the understanding of this connection.…”

mentioning

confidence: 99%

A micro bacteriological culture assessment of the histopathological alterations in liver and bile in gallstone disease

Jaiswal,

Ranjan,

Kumari

et al. 2024

Int J Res Med Sci

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Background: The present investigation aims to evaluate both the intensity and occurrence of hepatic impairment in patients afflicted with gallstone disease, examining the involvement of bacteria in the progression of these alterations. Methods: This prospective observational investigation was carried out on 189 patients scheduled for open or laparoscopic cholecystectomy at IGIMS in Patna, Bihar, India. In all the patients, laboratory and radiological investigations were performed. A healthy section of the liver border near the gallbladder fossa was chosen and grasped with non-traumatic forceps. Approximately 1 cm of the liver edge was excised using scissors and forwarded for histopathological analysis. Results: An examination of 189 liver biopsy specimens revealed that 87 (46%) patients showed no abnormalities, while 102 patients (54%) exhibited one or more changes. Upon analysing the liver biopsy samples from the control cohort (41 patients) during autopsy, 37% of the cases were identified to display hepatic lipidosis, while 48% of the cases showed lymphocytic invasion. Importantly, no cases of acute inflammatory changes were detected in the control cohort. Microbiological analysis was conducted on 96 patients, of which 33 (34%) showed positive cultures, with one or more microorganisms isolated from either the biliary tract or liver. Among these, 74% (24 cases) originated from the bile or gallbladder, while 26% (9 cases) were isolated from the liver. Conclusions: Gallstone disease induces significant liver histological changes, notably more prevalent in patients with prolonged symptoms. The present study clearly identifies this and underscores the importance of timely diagnosis and intervention for the effective management of this disease.

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Über vier Fälle von primärer sklerotischer Cholangitis

Sapkas¹,

Karavas²

1969

Langenbecks Archiv Für Chirurgie

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Histological Changes in the Liver in Diseases of the Biliary Tract

Cited by 9 publications

References 16 publications

Histological Liver Lesions Developing during Abdominal Operations

Histological Liver Lesions Developing during Abdominal Operations

A micro bacteriological culture assessment of the histopathological alterations in liver and bile in gallstone disease

Über vier Fälle von primärer sklerotischer Cholangitis

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