Histological changes in the liver, kidney and spleen of White Albino Rat after Aluminum Chloride administration

Mohammed, Hadaf H.

doi:10.30539/iraqijvm.v41i2.40

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…The accumulation of Al in the kidney is usually accompanied by renal failure (Ecelbarger et al, 1994). Moreover, Al accumulation in the kidney promotes degeneration in renal tubular cells, inducing nephrotoxicity (Somova et al, 1997;Mohamed et al, 2017). In addition, renal functions can also be altered in the early stages of hepatic damage before the formation of ascites (Monasterolo et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

The effect of Thymus vulgaris L. on renal and liver toxicity in wistar rats exposed to aluminum

Mokrane¹,

Kharoubi²,

Tahari³

et al. 2020

J. Med. Plants Res.

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The main sources of human exposure to aluminum are found in the extensive presence of the metal in the environment and its growing industrial applications. The present study was carried out to determine the effectiveness of the Thymus vulgaris L. extract in alleviating aluminum chloride (AlCl 3 ) toxicity on biochemical and antioxidant parameters. The experiment's rats were divided into five groups: a control group; an intoxicated group (300 mg AlCl 3 /kg bw); and three other groups which were given AlCl 3 (300mg/kg/bw) then T. vulgaris. L extract (T.v), Malic Acid (MA) and Vitamin E (Vit E) at a concentration of 150mg/kg/bw. Each group was given its respective dosage, daily for 90 days. The results showed a significant decrease in the body/liver/kidney weights, the plasma total protein (T. Protein) and albumin (Alb) levels (p≤0.05) in the intoxicated rats group. However, a significant increase in the plasma uric acid (Uac), alkaline (AlP) and acid phosphatase (AcP) levels was noted (p≤0.05) in the same group. The amount of aluminum, TBARS and nitrate/nitrite (NO) in the liver and kidney tissues of the rats treated with AlCl 3 was also found to have increased (p≤0.05), while the levels of glutathione peroxidase (GSH-Px) and glutathione transferase (GSH-St) have decreased significantly (p≤0.05). These altered parameters were restored in the rats treated with the T. vulgaris L. extract. Therefore, due to these beneficial effects, T. vulgaris L. could potentially be used to antagonize AlCl 3 toxicity.

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Section: Discussionmentioning

confidence: 99%

The effect of Thymus vulgaris L. on renal and liver toxicity in wistar rats exposed to aluminum

Mokrane¹,

Kharoubi²,

Tahari³

et al. 2020

J. Med. Plants Res.

View full text Add to dashboard Cite

show abstract

“…The toxic effect of Al on the liver and kidneys tissue is related to lipid peroxidation, which can induce significant harmful changes in some biochemical characteristics and redox status (Nawel et al, 2020). Therefore, the accumulation of Al in the kidney promoted degeneration in renal tubular cells (Mohammed et al, 2017). Exposure to Al in this study is thought to result in biochemical changes in the liver and kidneys, changes in hematological parameters such as red blood cells, hemoglobin, and changes in the histological structure of the liver and kidney cells.…”

Section: Discussionmentioning

confidence: 99%

Histological changes in liver and kidney of male mice by age after exposure to aluminum chloride

Irnidayanti,

Fatona,

Rizkawati

2023

Toxicol Ind Health

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The informal aluminum industry is increasingly widespread in low- and middle-income countries, especially in Indonesia. Aluminum exposure is a serious public health problem, especially among workers in the informal aluminum foundry sector. Research on aluminum (Al) is important to advance our understanding of its impact on physiological systems. Here, we investigated the effect of exposure to aluminum longitudinal histological changes on the liver and kidneys of male mice. Mice were separated into six groups (4/group): group 1, group 2, group 3 received vehicles, and group 4, group 5, group 6 were administered a single dose of Al at 200 mg/kg b.w. by intraperitoneally every 3 days for 4 weeks. Post-sacrifice, kidneys and liver were isolated for examination. While Al did not impact the body weight gain of male mice across all groups, it caused liver damage including sinusoidal dilatation, enlarged central veins, vacuolar degeneration, and pyknotic nuclei in one-month-old mice. Furthermore, atrophied glomeruli, blood-filled spaces, and disintegration of renal tubular epithelium are evident at one-month-age. By contrast, sinusoidal dilatation and enlarged central veins were found in mice two- and three-months-old, including hemorrhage in mice (two-month-old) and atrophy of glomeruli. Lastly, the kidneys of three-month-old mice displayed interstitial fibrosis and increasing mesenchyme in the glomeruli. In summary, we demonstrated that Al provoked histological changes in the liver and kidneys with Al-treated 1-month mice being the most susceptible.

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Effect of hesperidin in the prevention of aluminum chloride-induced testicular dysfunction in rats

Parasuraman,

Huey,

Jee

2024

Journal of Advanced Pharmaceutical Technology &Amp; Research

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Hesperidin is a citrus bioflavonoid and has numerous pharmacological actions. Hesperidin’s effect on testicular dysfunction has not been well researched. Hence, the present study is aims to investigate the effect of hesperidin on aluminium chloride (AlCl3)-induced testicular dysfunction in rats. Both vitamin C (200 mg/kg) and hesperidin (50, 100, and 200 mg/kg) were administered orally for 21 days. At the end of the study, the blood samples were obtained from all animals for investigation of biochemical and hematological parameters. Then, bilateral orchiectomy was carried out to remove testicles from the animals, and sperm was collected and examined under a microscope. Finally, organs such as the liver, kidney, and testicles were also collected and utilized for histopathological analysis. Part of the liver sample was used for determination of antioxidant enzymes such as reduced glutathione (GSH) and catalase (CAT) levels. The rats administered with AlCl3 showed elevated levels of biochemical and hematological parameters and a reduction in levels of sperm count, sperm motility, and oxidative stress parameters, whereas the rats administered with vitamin C/hesperidin (200 and 400 mg/kg) were able to ameliorate AlCl3-induced testicular dysfunction by attenuating AlCl3-induced changes in biochemical and hematological parameters, sperm motility, sperm count, and oxidative stress. Both vitamin C and hesperidin had significant ameliorative effects against AlCl3-induced testicular dysfunction.

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Histological changes in the liver, kidney and spleen of White Albino Rat after Aluminum Chloride administration

Cited by 3 publications

References 13 publications

The effect of Thymus vulgaris L. on renal and liver toxicity in wistar rats exposed to aluminum

The effect of Thymus vulgaris L. on renal and liver toxicity in wistar rats exposed to aluminum

Histological changes in liver and kidney of male mice by age after exposure to aluminum chloride

Effect of hesperidin in the prevention of aluminum chloride-induced testicular dysfunction in rats

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