Histological changes following intravenous cyclosporin in the treatment of refractory severe ulcerative colitis may mimic dysplasia

Hyde, G M; Warren, BF

doi:10.1016/s0016-5085(98)84070-5

Cited by 6 publications

(5 citation statements)

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“…25 26 Mucosal architectural abnormalities may however persist and appear as "pseudodysplasia" following treatment with cyclosporine. 33 Basal plasmacytosis and basal lymphoid aggregates can persist in rectal biopsies from patients with UC treated with sulphasalazine, 8 but the intensity can decrease significantly or the infiltrate may even disappear. 25 34 Treatment can induce patchiness or discontinuity of mucosal inflammation in UC, making a differential diagnosis between UC and CD more difficult and confirming the low discriminatory value of this feature.…”

Section: Microscopic Features and Medical Treatmentmentioning

confidence: 99%

Influence of treatment on morphological features of mucosal inflammation

Geboes

Dalle

2002

Gut

122

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Section: Microscopic Features and Medical Treatmentmentioning

confidence: 99%

Influence of treatment on morphological features of mucosal inflammation

Geboes

Dalle

2002

Gut

122

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“…Complete normalization of the mucosa, including architectural abnormalities, has been observed in UC with topical 5-ASA and non-systemic steroid treatment [25,26]. Mucosal architectural abnormalities may however persist and appear as`pseudodysplasia' following treatment with cyclosporin [33]. Basal plasmacytosis and basal lymphoid aggregates can persist in rectal biopsies from patients with UC treated with sulfasalazine [8], but the intensity can decrease signi®cantly or the in®ltrate may even disappear [25,34].…”

Section: The Evolution Of the Microscopic Diagnostic Features And Medmentioning

confidence: 99%

Pathology of inflammatory bowel diseases (IBD): variability with time and treatment

Geboes¹

2001

Colorect Dis

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The diagnosis of chronic idiopathic IBD and the differential diagnosis between Crohn's disease and ulcerative colitis can be made in most cases on cumulative clinical, radiological, endoscopical, biochemical and pathological evidence. Diagnostic difficulties can however, occur in fulminant colitis, in early onset disease and in long-standing disease. The microscopic evaluation of disease activity is based on the presence of active inflammation. Effective medical treatment has however, an influence upon the morphology and the evolution of the lesions and hence can affect the diagnostic features and the microscopic features used for the assessment of disease activity. A literature review was performed on clinical drug trials in IBD and the effect of the drugs upon the microscopic features. Several studies have shown that the diagnostic microscopic features and the features characteristic for disease activity vary with time and treatment. For an adequate analysis of biopsy samples of patients with IBD the pathologist should be aware of the duration of the symptoms and the type of treatment given to the patient.

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“…Complete normalization of the mucosa, including architectural abnormalities, has been observed in UC with topical 5‐ASA and non‐systemic steroid treatment [25,26]. Mucosal architectural abnormalities may however persist and appear as ‘pseudodysplasia’ following treatment with cyclosporin [33]. Basal plasmacytosis and basal lymphoid aggregates can persist in rectal biopsies from patients with UC treated with sulfasalazine [8], but the intensity can decrease significantly or the infiltrate may even disappear [25,34].…”

Section: The Evolution Of the Microscopic Diagnostic Features And Medmentioning

confidence: 99%

Pathology of inflammatory bowel diseases (IBD): variability with time and treatment

Geboes

2001

Colorectal Disease

View full text Add to dashboard Cite

The diagnosis of chronic idiopathic IBD and the differential diagnosis between Crohn's disease and ulcerative colitis can be made in most cases on cumulative clinical, radiological, endoscopical, biochemical and pathological evidence. Diagnostic dif®culties can however, occur in fulminant colitis, in early onset disease and in longstanding disease. The microscopic evaluation of disease activity is based on the presence of active in¯ammation. Effective medical treatment has however, an in¯uence upon the morphology and the evolution of the lesions and hence can affect the diagnostic features and the microscopic features used for the assessment of disease activity. A literature review was performed on clinical drug trials in IBD and the effect of the drugs upon the microscopic features. Several studies have shown that the diagnostic microscopic features and the features characteristic for disease activity vary with time and treatment. For an adequate analysis of biopsy samples of patients with IBD the pathologist should be aware of the duration of the symptoms and the type of treatment given to the patient.

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Histological changes following intravenous cyclosporin in the treatment of refractory severe ulcerative colitis may mimic dysplasia

Cited by 6 publications

References 0 publications

Influence of treatment on morphological features of mucosal inflammation

Influence of treatment on morphological features of mucosal inflammation

Pathology of inflammatory bowel diseases (IBD): variability with time and treatment

Pathology of inflammatory bowel diseases (IBD): variability with time and treatment

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