Histological Behavior of Hepatic Steatosis in Morbidly Obese Patients after Weight Loss Induced by Bariatric Surgery

Mottin, Cláudio Corá; Moretto, Myriam; Padoin, Alexandre Vontobel; Kupski, Carlos; Swarowsky, Aline Maria; Glock, Luiz; Duval, Vinicius; Silva, Jefferson Braga da

doi:10.1381/0960892054222830

Cited by 88 publications

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“…In our Hispanic population, 58% of the patients had some degree of NASH, and about 35% had some degree of fibrosis. The only patient that had cirrhosis was Hispanic [6,[8][9][10]. Adding the patients with steatosis and NASH, approximately 80% of the patients had some degree of fatty liver disease, which is also similar to what the literature describes [6].…”

Section: Discussionsupporting

confidence: 73%

“…The exact prevalence of NASH with and without liver fibrosis in the different populations like Caucasians, African American, Hispanics, and Asians has been a matter of research and remains to be clearly defined for each of them [6][7][8][9]. It is of great importance for bariatric surgeons to have clear knowledge of the disease prevalence, behavior, and the available diagnostic tests for liver fibrosis and NASH [10].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Nonalcoholic Fatty Liver Disease (NAFLD) and Utility of FIBROspect II to Detect Liver Fibrosis in Morbidly Obese Hispano-American Patients Undergoing Gastric Bypass

Guajardo-Salinas

Hilmy

2009

OBES SURG

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Section: Discussionsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Prevalence of Nonalcoholic Fatty Liver Disease (NAFLD) and Utility of FIBROspect II to Detect Liver Fibrosis in Morbidly Obese Hispano-American Patients Undergoing Gastric Bypass

Guajardo-Salinas

Hilmy

2009

OBES SURG

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“…Table 1 summarizes the main studies on the influence of bariatric surgery on NAFLD. In a historical cohort that enrolled 90 individuals who underwent liver biopsies during RYGB and one year afterwards, Mottin et al 135 observed that the prevalence of hepatic steatosis at the In a retrospective analysis on paired needle liver biopsies taken during and following RYGB in 39 patients, Liu et al 117 observed that the initial prevalences of hepatic pathological conditions were: steatosis (89.7%), hepatocellular ballooning (58.9%) and centrilobular/perisinusoidal fibrosis (50%). These improved significantly after RYGB: steatosis (2.9%), ballooning (0%) and centrilobular fibrosis (25%); significant decreases in the lobular inflammation score and stage of fibrosis were also noted.…”

Section: Bariatric Surgery and Nafldmentioning

confidence: 99%

Nonalcoholic fatty liver disease and bariatric surgery: a comprehensive review

2017

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CONTEXT AND OBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) has been increasingly diagnosed worldwide and is now recognized as a source of public health concern. It comprises a wide spectrum of histological features that range from simple steatosis to severe forms of fibrosis, steatohepatitis and even cirrhosis. The impact of bariatric surgery on the course of NAFLD in individuals with obesity has been extensively studied. DESIGN AND SETTING: Narrative review; public university hospital. METHODS: A comprehensive review was conducted based on an online search on the electronic databases MEDLINE and LILACS using the MeSH terms "fatty liver" and "bariatric surgery". RESULTS:The exact mechanisms that lead to improvement in NAFLD following bariatric surgery are not completely understood. Since Roux-en-Y gastric bypass (RYGB) is the bariatric surgical procedure most performed worldwide, it is also the one from which the effects on NAFLD have been most studied, although there is also consistent evidence regarding the effects from gastric banding, sleeve gastrectomy and biliopancreatic diversions. CONCLUSION: According to the currently available evidence, bariatric surgery leads to significant improvement in NAFLD. Further research, especially by means of randomized controlled trials enrolling larger cohorts of individuals, is needed to determine the optimal procedure for this group of subjects. RESUMO CONTEXTO E OBJETIVO:A doença hepática gordurosa não alcoólica (DHGNA) tem sido diagnosticada com maior frequência em todo o mundo na atualidade, sendo agora reconhecida como motivo de preocupação em saúde pública. Abrange um amplo espectro de alterações histológicas que variam desde a simples esteatose até formas graves de fibrose, esteato-hepatite e até cirrose. O impacto da cirurgia bariátrica sobre o curso da DHGNA em indivíduos com obesidade tem sido profundamente estudado. TIPO DE ESTUDO E LOCAL: Revisão narrativa; hospital universitário público. MÉTODOS: Uma revisão abrangente da literatura foi conduzida baseada na pesquisa on-line nas bases de dados eletrônicas MEDLINE e LILACS por meio dos termos MeSH "fígado gorduroso" e "cirurgia bariátrica". RESULTADOS: Os mecanismos exatos que levam à melhora da DHGNA após a cirurgia bariátrica não são completamente conhecidos. Como o bypass gástrico em Y de Roux é a cirurgia bariátrica mais realizada em todo o mundo, é também o procedimento cujos efeitos sobre DHGNA foram mais estudados, embora haja também evidências consistentes sobre os efeitos de banda gástrica, gastrectomia vertical e derivações biliopancreáticas. CONCLUSÃO: De acordo com as evidências atualmente disponíveis, a cirurgia bariátrica leva à melhora significativa da DHGNA. Mais estudos, especialmente por meio de ensaios clínicos randomizados e controlados, recrutando coortes maiores de indivíduos, são necessários para determinar o melhor procedimento para esse grupo de pacientes.

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“…One of the most effective and permanent methods for weight loss is bariatric surgery. Recent studies revealed some improvements in steatosis, inflammation, and liver fibrosis after bariatric surgery, but its efficiency for fatty liver and metabolic disorders was not proven so far (16)(17)(18)(19)(20)(21)(22)(23)(24). In contrast to several studies in this matter, there is a lack of a serum marker, which could be a decent predictive of NAFLD or the severity of NASH disease.…”

Section: Backgroundsmentioning

confidence: 96%

Predictive Factors of Steatosis and Non-Alcoholic Steatohepatitis in Morbidly Obese Patients Undergoing Bariatric Surgery

et al. 2017

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Background and Objectives: Obesity is one of the most health-threatening phenomena. It is estimated that over 1 billion adults have overweight or obesity. The current study aimed at presenting a detailed account of the findings that attempted to predict the severity of fatty liver disease and its sequelae, including non-alcoholic steatohepatitis (NASH), fibrosis, and cirrhosis, by correlating biopsy results with liver function tests and various metabolic markers of laboratory results in patients with morbid obesity.

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Histological Behavior of Hepatic Steatosis in Morbidly Obese Patients after Weight Loss Induced by Bariatric Surgery

Abstract: Significant improvement in the hepatic histology of steatosis was observed after weight loss induced by bariatric surgery in most patients. There was no patient with a worsening in the histology.

Cited by 88 publications

References 25 publications

Prevalence of Nonalcoholic Fatty Liver Disease (NAFLD) and Utility of FIBROspect II to Detect Liver Fibrosis in Morbidly Obese Hispano-American Patients Undergoing Gastric Bypass

Prevalence of Nonalcoholic Fatty Liver Disease (NAFLD) and Utility of FIBROspect II to Detect Liver Fibrosis in Morbidly Obese Hispano-American Patients Undergoing Gastric Bypass

Nonalcoholic fatty liver disease and bariatric surgery: a comprehensive review

Predictive Factors of Steatosis and Non-Alcoholic Steatohepatitis in Morbidly Obese Patients Undergoing Bariatric Surgery

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