“…To achieve appreciable periodontal regeneration, many studies 5,6,8,9,25,26 have supported the necessity of removing endotoxin and the smear layer of instrumentation on the root surface that is exposed in the periodontal pocket 25,26 . Chemical root conditioning of periodontitis‐affected root surfaces has been described with a number of agents of varying pH to eliminate factors that render the root surface bioincompatible for PDL associated with periodontal healing 27,28 .…”