Histological and ultrastructural evaluation of bone around Bio‐Oss^® particles in sinus augmentation

Abstract

Bio-Oss particles did not interfere with bone-healing processes after sinus augmentation procedures and promoted new bone formation. This study can help clinicians to understand better the morphological characteristics of bone regeneration processes using Bio-Oss after 20 months and, most importantly, after a longer time of interaction with surrounding tissues.

Functional assay, expression of growth factors and proteins modulating bone-arrangement in human osteoblasts seeded on an anorganic bovine bone biomaterial

“…In particular, they show that GBO harbours a great potential for hard tissue engineering purposes, and confirm the results obtained in clinical practice (Orsini et al, 2005;Orsini et al, 2007). However, additional clinical and in vitro studies are necessary to verify the functional response of the mesenchymal stem cells in presence of 3-D biomaterials.…”

“…It has been reported to be highly osteoconductive and to show a very low resorption rate (Piattelli et al, 1999;Sartori et al, 2003;Jensen et al, 2006;; moreover the bovine bone (Traini et al, 2008, Araújo andLindhe, 2009). In previous human studies evaluating maxillary sinus augmentation after 6 months and 7 years, GBO has been demonstrated to be well integrated in the host tissues and to produce new bone with features similar to pre-existing osseous tissue (Orsini et al, 2005;Orsini et al, 2007) and in vitro is well qualified to be a substrate for cell seeding (Jensen et al, 2006;Acil et al, 2002). These results are in contrast with the data demonstrating that the proliferation rate of osteoblast-like cells seeded on GBO was lower respect to other biomaterials (Turhani et al, 2005;Wiedmann-Al-Ahmad et al, 2005;Schmitt et al, 2008).…”

Maxillary Sinus Augmentation with a New Xenograft: A Randomized Controlled Clinical Trial

“…The osteoconductive properties of xenografts in human sinus grafting have been well documented . They are due to both their chemical composition and their macro and micro morphology.…”

The performance of CPC/PLGA and Bio‐Oss® for bone regeneration in healthy and osteoporotic rats

“…Several “off‐the‐shelf” synthetic bone substitutes are available for clinical bone regenerative treatments nowadays and worldwide research is done to enhance the properties of synthetic bone substitutes. For dental applications, Bio‐Oss ® is the mostly used commercially available bone substitute, consisting of devitalized bovine bone . Alternatively, calcium phosphate (CaP) based materials are synthetic inorganic biomaterials that show high similarity to bone tissue by resembling the mineral phase of bone and are already popular implant materials in several fields of surgery .…”