Histological and transcriptional study of angiogenesis and lymphangiogenesis in uninvolved skin, acute pinpoint lesions and established psoriasis plaques: An approach of vascular development chronology in psoriasis

Henno, A.; Blacher, Silvia; Lambert, Charles; Deroanne, Christophe; Noël, Agnès; Lapière, Charles M.; Brassinne, Michel De La; Nusgens, Betty; Colige, Alain

doi:10.1016/j.jdermsci.2009.12.006

Cited by 51 publications

(56 citation statements)

References 46 publications

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“…Thus, the PDPN-expression is frequently detected in the leading edge of malignant epithelial tumors, such as breast cancer and esophageal carcinoma [9]. The expression of PDPN is also recognized in epidermis, such as TPA-treated hyperproliferative mouse epidermis [9], psoriatic lesional epidermis [10], and the basal cell layer of sebaceous glands [11]. Although exogenous overexpression of PDPN increases cell motility in immortalized mouse keratinocytes [12], precise function of PDPN in human epidermal keratinocytes remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Podoplanin expression in wound and hyperproliferative psoriatic epidermis: Regulation by TGF-β and STAT-3 activating cytokines, IFN-γ, IL-6, and IL-22

Honma

Minami-Hori

Takahashi

et al. 2012

Journal of Dermatological Science

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Background Podoplanin (PDPN)/T1/aggrus/PA2.26 antigen, a transmembranous glycoprotein, is a well-known lymphatic endothelial marker. Recent evidence indicates that PDPN is also expressed in keratinocytes especially of sebaceous glands.Objective To verify expression-pattern and the regulatory mechanism of PDPN in human epidermal keratinocytes Methods PDPN-expression pattern was analyzed in normal and psoriatic epidermis by immunostaining. The regulatory mechanism of PDPN-expression of keratinocytes by cytokines was analyzed using specific inhibitors, siRNA, and adenoviral shRNA of signaling pathways.Results In normal skin, PDPN was expressed on the basal cell layer of sebaceous glands and on the outer root sheath of hair follicles. While no expression was detected in the normal interfollicular epidermis, PDPN was detected in the basal cell layer of wound and hyperproliferative psoriatic epidermis, where the granular layer is lacking.

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Section: Introductionmentioning

confidence: 99%

Podoplanin expression in wound and hyperproliferative psoriatic epidermis: Regulation by TGF-β and STAT-3 activating cytokines, IFN-γ, IL-6, and IL-22

Honma

Minami-Hori

Takahashi

et al. 2012

Journal of Dermatological Science

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“…17 Henno et al, however, showed an increased expression of not only NRP1 but also other pro-angiogenic factors, i.e., VEGF-A, VEGFR2, and PlGF, in psoriatic lesions compared to the uninvolved skin of the studied psoriatic patients. 18 The same authors also observed a significant overexpression of NRP1 in the nonlesional psoriatic skin in comparison to the skin of healthy volunteers.…”

mentioning

confidence: 83%

The expression of selected molecular markers of immune tolerance in psoriatic patients

Bartosińska¹,

Purkot²,

Kowal³

et al. 2018

Adv Clin Exp Med

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Background. Psoriasis is a chronic autoinflammatory disease whose underlying molecular mechanisms remain unclear. The disease is mediated by the cells and molecules of both the innate and adaptive immune systems. Some T cell surface molecules, including neuropilin-1 (NRP1), programmed death 1 (PD-1) and the human leukocyte antigen G (HLA-G), are known to play a role in the maintenance of immune tolerance.

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“…Whether these vascular alterations precede or succeed epidermal alterations is unclear because contradictory results were published [12,13]. However, such alterations are an early event resulting from the expansion of the existing blood vessels, not from sprouting angiogenesis [10,14].…”

Section: Vascular Alterationsmentioning

confidence: 99%

“…Angiogenesis in psoriasis is caused by high local concentration of vascular endothelial growth factor (VEGF), the VEFG 121 isoform being predominant [14][15][16]. Surprisingly, this isoform is also found in higher concentration within uninvolved skin, as compared to skin from healthy donors [17].…”

Section: Angiogenesis In Psoriasismentioning

confidence: 99%

The Role of Angiogenesis in the Pathogenesis of Psoriasis: Mechanisms and Clinical Implications

Guérard¹

2014

J Clin Exp Dermatol Res

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Histological and transcriptional study of angiogenesis and lymphangiogenesis in uninvolved skin, acute pinpoint lesions and established psoriasis plaques: An approach of vascular development chronology in psoriasis

Cited by 51 publications

References 46 publications

Podoplanin expression in wound and hyperproliferative psoriatic epidermis: Regulation by TGF-β and STAT-3 activating cytokines, IFN-γ, IL-6, and IL-22

Podoplanin expression in wound and hyperproliferative psoriatic epidermis: Regulation by TGF-β and STAT-3 activating cytokines, IFN-γ, IL-6, and IL-22

The expression of selected molecular markers of immune tolerance in psoriatic patients

The Role of Angiogenesis in the Pathogenesis of Psoriasis: Mechanisms and Clinical Implications

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