Histological and morphofunctional parameters of the hypothalamic–pituitary–adrenal system are sensitive to daidzein treatment in the adult rat

Trifunović, Svetlana; Manojlović‐Stojanoski, Milica; Nestorović, Nataša; Ristić, Nataša; Šošić‐Jurjević, Branka; Pendovski, L.; Milošević, Verica

doi:10.1016/j.acthis.2017.12.006

Cited by 3 publications

(2 citation statements)

References 35 publications

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“…Dietary exposure of genistein ranges from 5-500 ppm in rats during gestational and lactational periods results in an increased volume of the calbindin D28k-labeled in the sexually dimorphic nucleus of the medial preoptic hypothalamus in male offspring [182]. Daidzein treatment in orchidectomized rats showed higher levels of corticotropin-releasing hormone and increased numbers of adrenocorticotropic hormone (ACTH) cells, plasma ACTH, and serum corticosterone concentrations [183].…”

Section: Hypothalamusmentioning

confidence: 99%

The effect of soy isoflavones in brain development: the emerging role of multiple signaling pathways and future perspectives

Ariyani,

Koibuchi

2024

Endocr J

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Soybean is a source of protein, fibers, and phytochemical isoflavones which are considered to have numerous health benefits for children and adulthood. On the other hand, isoflavones are widely known as phytoestrogens that exert their action via the estrogen signaling pathway. With this regard, isoflavones are also considered as endocrine-disrupting chemicals. Endogenous estrogen plays a crucial role in brain development through binding to estrogen receptors (ERs) or G proteincoupled estrogen receptors 1 (GPER1) and regulates morphogenesis, migration, functional maturation, and intracellular metabolism of neurons and glial cells. Soy isoflavones can also bind to ERs, GPER1, and, furthermore, other receptors to modulate their action. Therefore, soy isoflavone consumption may affect brain development during the pre-and post-natal periods. This review summarizes the current knowledge on the mechanisms of isoflavone action, particularly in the early stages of brain development by introducing representative human, and animal models, and in vitro studies, and discusses their beneficial and adverse impact on neurobehavior. As a conclusion, the soy product consumption during the pre-and post-natal periods under proper range of dose showed beneficial effects in neurobehavior development, including improvement of anxiety, aggression, hyperactive behavior, and cognition, whereas their adverse effect by taking higher doses cannot be excluded. We also present novel research lines to further assess the effect of soy isoflavone administration during brain development.

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Section: Hypothalamusmentioning

confidence: 99%

The effect of soy isoflavones in brain development: the emerging role of multiple signaling pathways and future perspectives

Ariyani,

Koibuchi

2024

Endocr J

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“…There are some reports that daidzein may regulate inflammatory response and cortisol secretion (Meng et al, 2017 ; Das et al, 2018 ; Zeng et al, 2019 ). Svetlana et al revealed that histological and morphofunctional parameters of the HPA system were sensitive to daidzein treatment in adult rats (Trifunović et al, 2018 ). They found that daidzein inhibited adrenocorticotropic hormone (ACTH)-induced cortisol production in fetal and postnatal cells and reduced cAMP-stimulated cortisol release from H295 cells.…”

Section: Introductionmentioning

confidence: 99%

Daidzein Alleviates Hypothalamic-Pituitary-Adrenal Axis Hyperactivity, Ameliorates Depression-Like Behavior, and Partly Rectifies Circulating Cytokine Imbalance in Two Rodent Models of Depression

Chen

Wang

Zhang

et al. 2021

Front. Behav. Neurosci.

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Depression is one very common mental health disorder which can cause morbidity and mortality if not addressed. Recent studies have provided strong evidence that depression may be accompanied by immune activation, secondary inflammatory reaction, and hyperactivity of the Hypothalamic Pituitary Adrenal (HPA) axis. It is well-known that it takes at least 2 weeks for conventional antidepressants, especially SSRIs (Selective serotonin reuptake inhibitors) to produce effects. To better understand the mechanism of antidepressant effects on depression and subsequently further elucidate the pathogenesis of depression, we selected phytestrogen daidzein (DD) to observe its effects on the depression-like and anxiety-like behavior in two different rodent models of depression which were induced by learned helplessness and chronic mild stress (CMS) and then simultaneous evaluation of the depression-like behavior, the activity of HPA axis, and circulatory cytokines. Our results showed that daidzein attenuated depression-like behaviors through alleviating HPA axis hyperactivity, decreasing the levels of stress-related hormones, and partly rectifying some inflammatory cytokines imbalance in both the rodent models of depression.

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Anatomy and histology of the Göttingen minipig adenohypophysis with special emphasis on the polypeptide hormones: GH, PRL, and ACTH

et al. 2021

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Histological and morphofunctional parameters of the hypothalamic–pituitary–adrenal system are sensitive to daidzein treatment in the adult rat

Cited by 3 publications

References 35 publications

The effect of soy isoflavones in brain development: the emerging role of multiple signaling pathways and future perspectives

The effect of soy isoflavones in brain development: the emerging role of multiple signaling pathways and future perspectives

Daidzein Alleviates Hypothalamic-Pituitary-Adrenal Axis Hyperactivity, Ameliorates Depression-Like Behavior, and Partly Rectifies Circulating Cytokine Imbalance in Two Rodent Models of Depression

Anatomy and histology of the Göttingen minipig adenohypophysis with special emphasis on the polypeptide hormones: GH, PRL, and ACTH

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