Histological and immunohistochemical study on the possible ameliorating effects of thymoquinone on the salivary glands of rats with experimentally induced hypothyroidism

Effect of Bone Marrow Derived-Mesenchymal Stem Cells on Submandibular Salivary Glands of Carbimazole Induced Hypothyroidism in Albino Rats

“…Besides, in the present study the nuclei of the hypothyroid group appeared pyknotic and darkly stained or degenerated, and some exhibited pleomorphism. This foregoing observation goes in accordance with prior research that recognized degenerated cells with darkly stained cytoplasm and pyknotic nuclei in the parotid gland of hypothyroid rat (1) .…”

“…Histological examination of group II (hypothyroid induced group) revealed atrophied, shrunken and widely separated acini and ducts. Consistent with these findings, decreased number and size of the acini has been noted in the salivary glands of hypothyroid rats induced by propylthiouracil and methimazole respectively (1,2,15) . Moreover, extensive vacuolation was clearly evident within the acinar and ductal cytoplasm of group II.…”

“…Hypothyroidism is the condition in which the production of thyroid hormones declines beneath the normal level. As a consequence of impairment in mechanisms that controls the formation of thyroid hormones, thyroid dysfunction, or occurs due to complications throughout treatment of hyperthyroidism (1) . Deficiency of thyroid hormones production causes serious defects that may lead to stress and depression which disturb patient's daily functions.…”

The Potential Therapeutic Effect of Allogenic Bone Marrow Derived Mesenchymal Stem Cells on Carbimazole-Induced Hypothyroidism on Albino Rats’ Tongue.

“…Hypothyroidism; a syndrome caused by thyroid hormones deficiency, is the most common thyroid disorder. It may result from thyroid disorder, from damage in mechanisms that control the development of thyroid hormones, or can arise as a result of complications during the treatment of hyperthyroidism (3). The most common oral findings in hypothyroidism are macroglossia, delayed wound healing, dysgeusia, delayed eruption of teeth and altered tooth morphology (1) .…”

“…The associations between oral diseases and systemic diseases, especially those causing hormonal disturbances as thyroid dysfunction and diabetes mellitus had received great attention in the last few decades (3) . Since hypothyroidism is a systemic illness, pathological changes is expected to develop in the tongue structure of patient with hypothyroidism.…”