Histological and Histochemical Studies of the Adrenal Cortex in Experimentally Hypothyroid Pigeons

Bhattacharyya, Tapan K.; Ghosh, Asok

doi:10.1159/000142345

Cited by 12 publications

(1 citation statement)

References 6 publications

(6 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The adrenal cortex of the pigeon has been extensively studied by MILLER andRIDDLE (1942), SINHA et al (1959), BHATTACHARYYA and GHOSH (1963), BHATTACHARJEE and GHOSH (1964) and BHATTACHARYYA (1968 Central cortical cells are tall columnar with strongly acidophilic cytoplasm and round vesicular nuclei placed in a row near the basement membrane (Fig. 5, 13).…”

Section: Pigeonmentioning

confidence: 99%

A Comparative Histological Survey of the Avian Adrenocortical Homologue

Bhattacharyya

Sinha

Ghosh

1972

Arch. Histol. Jap., Arch. Histol. Jpn

Self Cite

View full text Add to dashboard Cite

Section: Pigeonmentioning

confidence: 99%

A Comparative Histological Survey of the Avian Adrenocortical Homologue

Bhattacharyya

Sinha

Ghosh

1972

Arch. Histol. Jap., Arch. Histol. Jpn

Self Cite

View full text Add to dashboard Cite

A comparative study on avian adrenocortical response to exogenous and endogenous corticotropin

et al. 1967

View full text Add to dashboard Cite

The transient effects of exogenous ACTH and unilateral adrenalectomy on the adrenal weight, histology, adrenal cholesterol and ascorbic acid were studied in several adult avian species. A single injection of ACTH produced a significant depression of adrenal ascorbic acid (AAA) in the pigeon (Columba Ziuia), the egret (BubuZcus ibis) and the myna (Acridotheres tristis). A fall in AAA was encountered in the unilaterally adrenalectomised pigeon and myna. A depletion of adrenal cholesterol induced by temporary ACTH treatment was noted in the pigeon, the egret and the myna; unilateral adrenalectomy produced a cholesterol depletion in the myna but not in the pigeon. Adrenal weight studies were not corroborative but there was a histological response of the interrend in various treatments.In mammals, the immediate response to systemic stress is manifested by adrenocortical hypertrophy and depletion of adrenal cholesterol and ascorbic acid. These adrenal responses have been studied in birds, but the results are often conflicting. Adrenal hypertrophy in the chick has been shown to accompany such stress stimuli as disease, muscular fatigue, reduced atmospheric pressure, and cold exposure (Hohn, '47; Garren and Schaf€ner, '56), increased population density (Siegel, '60), and increased social competition (Siegel and Siegel, '61). Contrarily, absence of adrenal hypertrophy in the chick in response to cold stress (Munday and BXane, '61) and single doses of ACTH has been noted (Dulin, '53; Huble, '58; Conner, '59). Flickinger ('59) also noted that dosages of ACTH that produce significant adrenal hypertrophy in laboratory mammals did not evoke such response in the Califomia quail. With chronic ACTH administration, however, a number of workers reported hypertrophy of bird adrenals (Bates et al., '40; Miller and Riddle, '42; Jailer and Boas, '50; Zarrow and Baldini, '52; Garren and Hill, '58; Brown et al., '58; Garren et al., '61).Siegel and Beane ('61) observed that, although adrenal hypertrophy was not produced by single ACTH injections, there was adrenal cholesterol depletion, hyperglycemia and hypercholesteremia. Siegel ('62) also concluded that age and ACTH treat-J. EXP. ZOOL., 165: 301-308. ment together influenced the adrenal cholesterol level in the chicken. A single ACTH injection was found to lower total adrenal cholesterol in the chicken 12 hours following administration (Koji and Glick, '64), but not within 1-4 hours of ACTH or cold treatment (Elton et al., '59). A bigger controversy remains with respect to experimental ascorbic acid depletion from avian adrenals, which is a common response to mammalian stress. The failure of parasitic infection, ACTH, epinephrine and cold to influence the adrenal ascorbic acid in the chick, quail or duckling has been reported (Josephson et al., '49; Jailer and Boas, '50; Zarrow and Zarrow, '50; Zarrow and Baldini, '52; Howard and Constable, '58; Elton et al., '59). Recently corticotropin-induced ascorbic acid depletion has been reported in one-year old laying hens, moltin...

show abstract

Histomorphic changes following chronic adrenocortical activation and inhibition in the pigeon

Bhattacharyya

Ghosh

1970

Journal of Morphology

View full text Add to dashboard Cite

Gravimetric and histologic modifications in the pigeon were studied following chronic therapy with ACTH and metopirone (SU 4885) for a period of 15 days. The organs studied were proventriculus, duodenum, heart, kidney, salivary gland, pancreas, liver, uropygial gland, thymus. spleen, bursa fabricii, testis, ovary, islets of Langerhans, adenohypophysis, thyroid and interrenal and chromaffin tissue of the adrenal gland. Induced states of hyper-and hypoadrenocorticalism elicited pathomorphic changes i n endocrine and reproductive systems and some other organs of the pigeon. There were many differences and similarities i n the nature of response of some organs following the two experimental ccnditions. Many of these cellular interactions might have resulted from alteration of interrenal function i n the pigeon.The adrenocorticosteroids are intimately associated with metabolic homeostasis of the vertebrate body (Chester Jones and Beilamy, '64) and administration of corticosteroids or adrenocorticotrophin is known to produce changes in cell structure at the level of various body tissues. Histological changes in the body of the rat during long periods of ACTH administration and inanition were described by Baker ('52). Waxler ( '63) described gravimctric and histologic modifications in several organs of intact and hypophysectomised rats following chronic therapy with various doses of corticotrophin and a number of other steroids. In the eel, histologic changes in several organs have been described in response to chronic treatment with a corticoid-blocking agent, SU 4885 or mctopirone (Olivereau. '65). In birds, ACTH or corticoids of mammalian origin have been recorded to produce some changes of electrolyte and carbohydrate metabolism (dc Roos. '63), but their effects on the histology of avian organ systems have not been studied.In this investigation, eEects of chronic hyper-and hypoadrenocorticalism induced by ACTH and metopirone respectively, 011 various body tissues of the pigeon were studied to see how far metabolic alteration of avian interrenal function is detectable at the tissue level. Corticosterone has been recognised as the major adrenal steroid se- RESULTS A . Graoimetric observationsInitially, there was little difference between control, ACTH and metopirone groups of animals. Both experimental groups treated chronically with corticotrophin and SU 4885 showed a suppression of body weights. While the control group gained body weight throughout the experimental period, the other groups showed a significant retardation of body weights (table 1).Organ weight. The absolute and relative weights of adrenal, thyroid, testis, ovary, spleen, kidney, bursa of fabricius and heart were recorded under experimental conditions and analysed statistically. In the ACTH group, only the absolute kidney weight was retarded; other organ weights were unchanged. Following metopirone treatment, a depression in absolute weights of the ovary and heart was noticed. The relative adrenal weight was increased. Body weight. B. Adrena...

show abstract

Histological and Histochemical Studies of the Adrenal Cortex in Experimentally Hypothyroid Pigeons

Cited by 12 publications

References 6 publications

A Comparative Histological Survey of the Avian Adrenocortical Homologue

A Comparative Histological Survey of the Avian Adrenocortical Homologue

A comparative study on avian adrenocortical response to exogenous and endogenous corticotropin

Histomorphic changes following chronic adrenocortical activation and inhibition in the pigeon

Contact Info

Product

Resources

About