Histological and Histochemical Changes in the Colon Mucosa after
Ureterosigmoidostomy or Colonic Conduit

Rm, Tomasino; Morello,; Ma, Latteri; Spinnato, G; Pantuso, Gianni; Orestano, F.

doi:10.1159/000473445

Cited by 13 publications

(3 citation statements)

References 27 publications

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“…The suture thread may also shorten latency time to carcinogenesis while the fecal bolus may act as a continuous and prolonged aggression 17 . These changes, also present in the intestinal segment of the neobladder, suggest isolated action of urine as a cause of lymphoid depletion in intestinal segments, which could in turn promote the carcinogenesis process 16,20 . Atrophy of tunic muscularis, although found in all groups, was mild and non-significant, mirroring the observations of other studies 19 .…”

Section: Discussionmentioning

confidence: 99%

“…The chronic inflammatory process, observed significantly in all groups, suggests that surgical trauma and the presence of suture thread may have caused the local acute reaction. The constant presence of urine or other carcinogens may have caused chronic reaction in stroma tissue with severe infiltration of monocytic cells 15,20 . The suture thread may also shorten latency time to carcinogenesis while the fecal bolus may act as a continuous and prolonged aggression 17 .…”

Section: Discussionmentioning

confidence: 99%

“…Hyperplasia and hypertrophy of the tunic muscular in ileovesical anastomosis and in the intestinal segment of the neobladder was significant and most likely the result of local surgical trauma aggravated by the presence of urine. Several authors have observed only muscular hyperplasia 11,21 while others have found muscular hypertrophy arising from probable bladder strength 7,20,22,23 . Fibrosis, which proved statistically significant in all groups, reflected the chronic response of tissues to initial aggression of surgical trauma, aggravated by other continuous aggressions 17 .…”

Section: Discussionmentioning

confidence: 99%

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Early morphological and histochemical alterations in rats subjected to ileocystoplasty

et al. 2009

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Purpose:To study morphologic and histochemical alterations arising at the ileocystoplasty site. Methods: Sixteen Wistar female rats were subjected to ileocystoplasty and sacrificed after eight weeks. Material collected was divided into four groups for histological and histochemical studies: Group I (control) -isolated ileum segment removed during ileocystoplasty; Group II -ileoileal anastomosis; Group III -ileovesical anastomosis and Group IV -ileal segment from the neobladder. Histological and histochemical study assessed dysplasia, metaplasia, acute and chronic inflammation, fibrosis, atrophy, hypertrophy, total mucins, sialomucins and sulfomucins. The non-parametric Wilcoxon and Mann-Whitney tests were employed in statistical analysis. Results: None of the groups presented dysplasia. Acute inflammation and atrophy occurred in Groups II, III and IV, not reaching statistical significance. Metaplasia was significant only in Group III (p=0.012). Chronic inflammation, fibrosis and hypertrophy were significant in Groups II, III and IV. There was a significant increase in total mucin content in Group IV (p=0.014) and a reduction in Group III (p=0.016). Increases in sialomucins were observed in samples for Groups III (p=0.003) and IV (p=0.002) along with reduced sulfomucins in samples from Groups III (p=0.013) and IV (p=0.008). Conclusion: Ileocystoplasty in female rats caused squamous metaplasia, chronic inflammatory infiltration, fibrosis, hypertrophy, increase in sialomucin content, reduction in sulfomucins, and alterations in total mucin content with statistical significance, as well acute inflammatory infiltration and muscular atrophy with less intensity. Key words: Urinary Diversion. Neoplasm. Mucins. Sialomucins. Urinary Bladder. Ileum. RESUMOObjetivo: Estudar alterações morfológicas e histoquímicas nas ileocistoplastias em ratos fêmea. Métodos: 16 ratos fêmea foram submetidos à ileocistoplastia, sacrificadas após oito semanas. O material coletado foi e dividido em quatro grupos para análise morfológica e histoquímica: Grupo I (controle) biópsia intestinal no momento da cirurgia; Grupo II -anastomose íleo-ileal; Grupo III -anastomose íleo-vesical e Grupo IV -segmento intestinal da neobexiga. Os parâmetros avaliados foram: displasia, metaplasia, processo inflamatório agudo e crônico, fibrose, atrofia, hipertrofia, conteúdo total de mucinas, sialomucinas e sulfomucinas. Utilizou-se os testes não-paramétricos de Wilcoxon e Mann-Whitney para estudo estatístico. Resultados: Não houve displasia. Processo inflamatório agudo e atrofia ocorreram nos grupos II, III e IV, sem significância estatística. Metaplasia com significância estatística ocorreu somente no grupo III (p=0.012). Processo inflamatório crônico, fibrose e hipertrofia foram significantes nos grupos II, III e IV. Observou-se aumento significante no conteúdo total de mucinas no grupo IV (p=0.014) e redução no grupo III (p=0.013). Aumento significante de sialomucinas foi observado nos grupos III (p=0.003) e IV (p=0.002) e redução significante das su...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Early morphological and histochemical alterations in rats subjected to ileocystoplasty

et al. 2009

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Malignancy associated with urinary tract reconstruction using enteric segments

Spencer

Filmer²

1992

Therapy for Genitourinary Cancer

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The sigma rectum pouch (Mainz pouch II)

Fisch¹,

Wammack²,

Hohenfellner³

1996

World J Urol

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A low-pressure reservoir for urine is created by antimesenteric splitting and side-to-side anastomosis of the rectosigmoid, the expectation being to obtain better continence rates and better protection of the upper tract than are achievable by ureterosigmoidostomy. Between 1990 and August 1993 the procedure was performed in 73 patients (59 adults and 14 children) whose mean age was 43.5 years. The indications were malignancy (n = 55), bladder exstrophy/epispadias (n = 14), trauma (n = 3), and sinus urogenitalis (n = 1). Of the 73 patients, 69 were followed for a mean period of 127 (range, 1-34) months. In all, 5 early complications were encountered (6.8%). In addition, 8 late complications occurred (10.9%), stenosis at the ureteral implantation site being the most common one. Daytime continence was 94.5% and night-time continence, 98.6%. The sigma rectum pouch achieves excellent continence rates. Despite implantation of the ureters into a low-pressure reservoir, stenosis at the site of ureteral implantation occurred in 6.8% of the patients, demonstrating the profund vulnerability of ureterointestinal anastomosis.

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Histological and Histochemical Changes in the Colon Mucosa after Ureterosigmoidostomy or Colonic Conduit

Cited by 13 publications

References 27 publications

Early morphological and histochemical alterations in rats subjected to ileocystoplasty

Early morphological and histochemical alterations in rats subjected to ileocystoplasty

Malignancy associated with urinary tract reconstruction using enteric segments

The sigma rectum pouch (Mainz pouch II)

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