Histological and Clinicopathological Evaluation of Liver Allograft Biopsy: An Initial Experience of Fifty Six Biopsies

Kanodia, Kamal V; Vanikar, A V; Modi, Pranjal; Patel, Roshni; Suthar, Kalpit; Nigam, Lovelesh K.; Trivedi, Hargovind L

doi:10.7860/jcdr/2015/13664.6812

Cited by 2 publications

(9 citation statements)

References 33 publications

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“…Most patients were males in agreement with Kanodia et al [16]. In comparison to biopsy free patients, most patients had more liver dysfunction that was assessed by the ALBI score Most of the liver functions are elevated more than 2-3 folds and the wide fluctuations were with AST, ALT, GGT, and ALP.…”

Section: Discussionsupporting

confidence: 87%

“…In the current study, 89 patients were followed up where 38.2% underwent liver biopsy mainly for suspecting acute rejection or recurrent diseases especially viral ones. Some patients underwent single biopsy and some patients underwent repeated biopsies consistent with other studies [14][15][16]18]. The average age was 44 years that is lower than Kanodia et al [16], and higher than Geramizadeh et al [15] as he enrolled pediatric cases.…”

Section: Discussionmentioning

confidence: 64%

“…Regarding indications of liver transplantation, the first one was HCV related decompensated liver disease followed by HCC on top of HCV related liver disease. In the other studies, the indication was different according to the geographical distribution, so in the Iranian study HBV was the main one [15], whereas alcohol in the Indian study [16].…”

Section: Discussionmentioning

confidence: 96%

“…In another study, Kanodia et al [16] studied 57 biopsies from 35 patients (January 2010 to July 2014). Some patients underwent repeated biopsies.…”

Section: Discussionmentioning

confidence: 99%

“…The average time till the 1st liver biopsy was 19.88 (10-93) months. Some centers did very early liver biopsy within hours postoperatively as with Geramizadeh et al [15], Kanodia et al [16], and some center earlier time as with Voigtlander et al [17]. The different histopathological diagnosis was not affected by the time till biopsy.…”

Section: Discussionmentioning

confidence: 99%

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Liver biopsy is still needed in liver transplantation recipients: a single center experience

Abdelsameea

Alsebaey

Ehsan

et al. 2020

Egypt Liver Journal

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Background: Liver transplantation is a final treatment for decompensated liver disease.Aim: Description of post-liver transplant histopathology. We enrolled 89 patients divided into two groups according to if they underwent on demand liver biopsy (n = 34; 38.2%) or not (n = 55; 61.8%). Albumin-bilirubin (ALBI) score and model for end-stage liver disease (MELD) assessed the degree of liver dysfunction. Results: Patient underwent liver biopsy (LB) was 44.65 ± 8.46 years old, mainly males (88.2%) with average MELD of 8.74 ± 4.71. Most patients were positive pre-transplant for HCV (91.2%) and 29.4% had hepatocellular carcinoma on top of hepatitis C. Patients underwent LB had worse liver dysfunction by ALBI score (− 2.62 ± 0.6 vs. − 2.96 ± 0.5; p = 0.014) but comparable MELD. The time till first biopsy was 19.88 ± 11.22 (4-44) months. It was not different statistically with various histopathology (p > 0.05). Histopathology of first biopsy was viral chronic hepatitis (50%), acute rejection (20.6%), steatohepatitis (11.8%), chronic rejection (5.9%), chronic hepatitis (5.9%), biliary obstruction (2.9%), and cytomegalovirus hepatitis (2.9%). Most patients were F1 (38.2%) and A1 (35.3%). The immunosuppressive drug regimen had no impact on the histopathology (p > 0.05). Patients with hepatitis C pre-transplant had in a descending manner the following histological diagnosis (p = 0.001): viral chronic hepatitis 16 (51.6%), acute rejection 7 (22.6%), steatohepatitis 4 (12.9%), chronic rejection 2 (6.5%), biliary obstruction 1 (3.2%), and CMV hepatitis 1(3.2%). Some patients required on demand second (n = 9) and third biopsied (n = 5) that were the same as the first biopsy or completely different. Conclusion: Liver biopsy is a useful tool for diagnosis of liver transplantation complications.

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Section: Discussionsupporting

confidence: 87%