Histological and biochemical evaluation of the antidiabetic potentials of s-allyl-cysteine and mangiferin in type 2 diabetic rat models

Iliya, IA; Mohammed, Bisalla; Akuyam, SA; Yaro, JD; Timbuak, James Abrak; Tanko, M; Nok, AJ

doi:10.4103/2384-5147.176306

Cited by 2 publications

(5 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Koopmans et al ( 31 ) reported that in adult Sprague-Dawley rats, hyperinsulinemia stimulated de novo lipogenesis, inhibited glycogenesis, and triggered insulin resistance. We thus hypothesise that the changes in liver lipid content in female rat pups and insulin sensitivity (as indicated by HOMA-IR) in male rat pups to which SAC only was orally administered may be ascribed to the potential insulinotropic effects of SAC as reported by the current study and other previous studies ( 13 , 14 , 24 ). Although our findings point to the potential health beneficial insulinotropic effects of SAC, it could potentially cause adverse metabolic effects typified by excessive hepatic lipid accretion in suckling female rats and insulin resistance in male rats.…”

Section: Discussionsupporting

confidence: 69%

“…The oral administration of SAC alone resulted in increased plasma insulin concentration in male rat pups suggesting that SAC possesses insulinotropic properties. SAC has been shown to possess antihyperglycaemic, insulinotropic, and antihyperlipidaemic properties in STZ-diabetic rats and high-fat diet NAFLD rat models ( 14 , 17 , 24 ). The mechanisms by which SAC exerts these beneficial properties have been attributed to its ability to stimulate insulin secretion by pancreatic β-cells, promote regeneration and longevity of pancreatic β-cells, and upregulate lipolytic genes and enzymes in the liver ( 17 , 24 ).…”

Section: Discussionmentioning

confidence: 99%

“…It contains health beneficial phytochemicals such as alliin, diallyl disulphide, and S -allyl cysteine (SAC) ( 12 ). SAC, a water-soluble organosulphur peptide found in abundance in aged garlic preparations, has been shown in vitro and in vivo to possess health beneficial properties ( 13 , 14 ). The administration of SAC at 50~150 mg/kg body weight was shown to attenuate hyperglycaemia, hypoinsulinaemia, hyperlipidaemia, and oxidative stress in adult STZ-diabetic rats ( 14 – 16 ).…”

Section: Introductionmentioning

confidence: 99%

“…SAC, a water-soluble organosulphur peptide found in abundance in aged garlic preparations, has been shown in vitro and in vivo to possess health beneficial properties ( 13 , 14 ). The administration of SAC at 50~150 mg/kg body weight was shown to attenuate hyperglycaemia, hypoinsulinaemia, hyperlipidaemia, and oxidative stress in adult STZ-diabetic rats ( 14 – 16 ). Takemura et al ( 17 ) reported that in vivo SAC alleviated hypercholesterolemia and hypertriglyceridemia in non-alcoholic fatty liver diseased Otsuka Long-Evans Tokushima male rats.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Insulinotropic Effect of S-Allyl Cysteine in Rat Pups

Lembede

Joubert

Nkomozepi

et al. 2018

pnf

View full text Add to dashboard Cite

S-Allyl cysteine (SAC) is found in garlic and has been reported to exert antidiabetic and antiobesity properties in drug-induced adult experimental models of metabolic dysfunction, but its potential beneficial effects in high-fructose diet neonatal rat models have not been determined. This study investigated the potential prophylactic effects of SAC in high-fructose diet fed suckling rat pups modelling human neonates fed a high-fructose diet. Four-day-old male (n=32) and female (n=32) Wistar rat pups, were randomly assigned to and administered the following treatment regimens daily for 15 days: group I, distilled water; group II, 20% fructose solution (FS); group III, SAC; group IV, SAC+FS. The pups’ blood glucose, triglyceride, cholesterol, plasma leptin and insulin concentration, liver lipid content, and liver histology were determined at termination. In female rat pups, orally administered SAC prevented FS-induced hypoinsulinemia but significantly increased (P≤0.05) liver lipid content. Oral administration of SAC significantly increased (P≤0.05) plasma insulin concentration and homeostasis model assessment for insulin resistance in the male pups. The potential sexually dimorphic effects of SAC (insulinotropic effects in male pups and protection of female pups against fructose-induced hypoinsulinemia) suggest that SAC could be potentially exploited as an antidiabetic and insulinotropic agent. Caution should, however, be exercised in the use of SAC during suckling as it could result in excessive liver lipid accumulation and insulin resistance.

show abstract

Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Insulinotropic Effect of S-Allyl Cysteine in Rat Pups

Lembede

Joubert

Nkomozepi

et al. 2018

pnf

View full text Add to dashboard Cite

show abstract

“…In Nigeria, Parkia biglobosa seeds are commonly used as ingredients in local dishes; asides this, it is used as alternative medicine for the management of diabetes. Hence, the need to verify its efficacy in mitigating diabetic complications and its effects on the patient [34][35][36] .…”

Section: R E S U L T S a N D Discussionmentioning

confidence: 99%

Gut Microbiota Hypolipidemic Modulating Role in Diabetic Rats Fed with Fermented Parkia biglobosa (Fabaceae) Seeds

Awoyinka

Omodara

Oladele

et al. 2020

RADS J. Biol. Res. Appl. Sci

View full text Add to dashboard Cite

Background: Modulation and balancing of host gut microbiota by probiotics has been documented by several literature. Prebiotic diets such as locust beans have been known to encourage the occurrence of these beneficial microorganisms in the host gut. Objectives: To study the modulating role of gut microbiota in the hypolipidemic effect of fermented locust beans on diabetic Albino Wister rats as animal models. Methodology: Albino rats (Wistar strain), averagely weighing 125g were successfully induced with alloxan. Thereafter this induction, anti-diabetic treatment was carried out on various groups of rats by feeding them ad-libitum with a diet of milled fermented and unfermented Parkia biglobosa seeds, respectively. Results: After three weeks of treatment, it was observed that fermented locust beans caused a significant reduction (p ≤ 0.05) in glucose, total triglycerides, total cholesterol and LDL, while the HDL levels were significantly elevated (p ≤ 0.05). Results of faecal analysis showed that the fermented locust beans modulated the gut microbiota through the occurrence of probiotic bacteria, Bacillus subtilis in the gut and faeces of the rats. Conclusion: This study support that fermented locust beans is a prebiotic diet that encourages the growth of Bacillus subtilis in the gut of animals and is associated with hypolipidemic activities which alleviate diabetes as portrayed in these rat models.

show abstract

Histological and biochemical evaluation of the antidiabetic potentials of s-allyl-cysteine and mangiferin in type 2 diabetic rat models

Cited by 2 publications

References 1 publication

Insulinotropic Effect of S-Allyl Cysteine in Rat Pups

Insulinotropic Effect of S-Allyl Cysteine in Rat Pups

Gut Microbiota Hypolipidemic Modulating Role in Diabetic Rats Fed with Fermented Parkia biglobosa (Fabaceae) Seeds

Contact Info

Product

Resources

About