Histological analysis of the periodontal ligament and alveolar bone during dental movement in diabetic rats subjected to low-level laser therapy

Maia, Luiz Guilherme Martins; Alves, Ângela Valéria Farias; Bastos, Talita Santos; Moromizato, Lucas Sandes; Lima-Verde, I.B.; Ribeiro, Maria Amália Gonzaga; Júnior, Luiz Gonzaga Gandini; Albuquerque‐Júnior, Ricardo Luiz Cavalcanti de

doi:10.1016/j.jphotobiol.2014.03.023

Cited by 10 publications

(10 citation statements)

References 26 publications

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“…It has been supported that the ability of LLLT to suppresses the plasminogen activator production of COX-2, phospholipase A2 (enzymes responsible to produce PGE2), PGE2, IL-1b, prevents the degradation of the extracellular matrix since it reduces collagen destruction that occurs when the cells are found under stress conditions [68]. Furthermore, the beneficial effect of LLLT on the proliferation of periodontal ligament cells has been strongly supported [69][70][71], whereas other investigators have questioned it [46]. Interesting is a study which evaluated the possible additional effect of LLLT in the implementation of protein matrix of the enamel (Emdogain®), in endosteal injuries which were caused by periodontitis in humans.…”

Section: Low Level Laser Therapy (Lllt) and Healing Of Tissuesmentioning

confidence: 96%

Effects and Action Mechanism of Low Level Laser Therapy (LLLT): Applications in Periodontology

Karoussis¹,

Kyriakidou²,

Psarros³

et al. 2018

Dentistry

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Lasers nowadays have several applications in many research fields. In the life sciences and especially in Periodontology, Low Level Laser Therapy (LLLT) has proven to be particularly interesting. Low intensity radiation in specific wavelengths has been known to trigger cellular proliferation and differentiation, through molecular mechanisms that are still not fully elucidated. These effects might be triggered by mitochondria and through Reactive Oxygen Species (ROS). These in turn, can activate other molecular pathways and signaling cascade, resulting in the activation of a plethora of transcriptional factors. In this review we aim to highlight the mechanism of action and the effects of LLLT. We also aim to highlight how different wavelengths and energy applied can have a distinct impact on the effectiveness of LLLT. Finally, we provide insight on its current and potential future applications.

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Section: Low Level Laser Therapy (Lllt) and Healing Of Tissuesmentioning

confidence: 96%

Effects and Action Mechanism of Low Level Laser Therapy (LLLT): Applications in Periodontology

Karoussis¹,

Kyriakidou²,

Psarros³

et al. 2018

Dentistry

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“…Diabetes mellitus (DM) is a metabolic disorder characterized by deficiency of insulin secretion or action, leading to chronic hyperglycemia and disturbances of carbohydrate, fat, and protein metabolism. The major complications of diabetes include microangiopathy, retinopathy, nephropathy, neuropathy, cardiovascular disease, susceptibility to infections, delayed tissue repair, and severe periodontal disease [1][2][3][4][5][6][7]. Considering the bone metabolic disorder in diabetes, imbalance between the alveolar bone formation and resorption processes is found due to decreased osteoblast activities and/or enhanced apoptosis of osteoblastic cells [4].…”

Section: Introductionmentioning

confidence: 99%

“…However, if diabetes is uncontrolled or poorly controlled, severe degradation of periodontal tissues may occur, becoming a contraindication for orthodontic treatment until the metabolic disorder is compensated [1]. As an alternative support treatment to obtain an appropriated tooth movement and bone remodelation, the photobiomodulation (PBM), also known as low-level laser therapy (LLLT), has been largely used to promote therapeutic and biostimulating effects, such as analgesia, anti-inflammatory action, angiogenesis, and mitogenesis [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Effects of the GaAlAs diode laser (780 nm) on the periodontal tissues during orthodontic tooth movement in diabetes rats: histomorphological and immunohistochemical analysis

et al. 2017

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The purposes of the present study are to assess the effects of the GaAlAs diode laser on the periodontal tissues and to investigate its action on the alveolar bone remodeling process during orthodontic tooth movement in normoglycemic and diabetic rats. Sixty adult male Wistar rats were divided into four groups of 15 rats: normoglycemic (N), diabetic (D), laser-normoglycemic (LN), and laser-diabetic (LD) rats. Diabetes mellitus was induced by a single intravenous injection of 40 mg/kg monohydrated alloxan. The orthodontically moved tooth underwent a force magnitude of 20 cN. The laser irradiation with a continuous emission of a 780-nm wavelength, an output power of 20 mW, and a fiber probe with a spot size of 0.04 cm in diameter and an area of 0.00126 cm were used. Moreover, an energy density of 640 J/cm was applied in an exposition time of 40 s. Histomorphological and immunohistochemical analysis was performed. The photobiomodulation (PBM) strongly stimulated the periodontal tissue response, establishing mainly the balance between the bone formation and resorption. Intense inflammatory cell infiltration and extensive loss of bone tissue were mainly found in the D group from 14 days. The number of osteopontin-positive osteocytes was significantly greater in the LN group, followed by the LD, especially at 7 and 14 days, whereas osteoprotegerin-positive osteoblasts were significantly higher in the LN and LD groups than in the N and D groups, respectively, in all periods. The PBM strongly stimulated the alveolar bone remodeling and favored the continuous reorganization of the soft periodontal tissues, leading to the maintenance and integrity of the periodontal microstructure under orthodontic force, especially in uncontrolled diabetic rats.

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“…Estudos observaram que tanto a movimentação dentária ortodôntica decorrente da ortodontia, foram significantemente menores em ratos diabéticos do que em ratos normais (Arita et al, 2016). Maia et al (2014), ao analisarem as alterações histológicas do ligamento periodontal e osso alveolar após a movimentação dentária em ratos com diabetes, observaram alterações metabólicas e efeitos indesejáveis na remodelação óssea pós forças leves. Na literatura observase um relato de caso de DM associado ao tratamento de expansão rápida da maxila (ERM), no qual o paciente apresentou uma úlcera necrótica no palato após a ERM, e a reversão dos sinais e sintomas após identificação e tratamento do DM1 (Maia et al, 2011).…”

Section: Figura 7-unclassified

“…A utilização de ratos Wistar como modelo de estudo, tem sido amplamente relatada na literatura (Maia et al, 2014;Gomes et al, 2017;Ferreira et al, 2018), além de minimizar fatores de confusão que podem haver em humanos. A escolha de machos foi para não haver interferência de hormônios do ciclo reprodutivo feminino.…”

Section: Animais Submetidos à Eutanásia 3 Dias Após Ermunclassified

Avaliação do periodonto de sustentação após a aplicação de forças ortopédicas, em ratos diabéticos

Okada¹

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Histological analysis of the periodontal ligament and alveolar bone during dental movement in diabetic rats subjected to low-level laser therapy

Cited by 10 publications

References 26 publications

Effects and Action Mechanism of Low Level Laser Therapy (LLLT): Applications in Periodontology

Effects and Action Mechanism of Low Level Laser Therapy (LLLT): Applications in Periodontology

Effects of the GaAlAs diode laser (780 nm) on the periodontal tissues during orthodontic tooth movement in diabetes rats: histomorphological and immunohistochemical analysis

Avaliação do periodonto de sustentação após a aplicação de forças ortopédicas, em ratos diabéticos

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