Histologic variants in bladder cancer harbor aggressive molecular features including TM4SF1 expression and a CA125+ cell state
Heiko Yang,
Hanbing Song,
Elizabeth Yip
et al.
Abstract:Histologic variant (HV) subtypes of bladder cancer are clinically aggressive tumors that are more resistant to standard therapy compared to conventional urothelial carcinoma (UC). Little is known about the transcriptional programs that account for the morphological and biological differences in HV tumors. To investigate the tumor biology of HV bladder cancers, we generated a single cell RNA sequencing (scRNA-seq) atlas of nine HV tumors and three UC tumors. Our analyses revealed a tumor cell state specific to … Show more
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