Histologic types of epithelial ovarian cancer: have they different risk factors?

Kurian, Allison W.; Balise, Raymond R.; McGuire, Valerie; Whittemore, Alice S.

doi:10.1016/j.ygyno.2004.10.037

Cited by 151 publications

(166 citation statements)

References 64 publications

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“…5 Calculated as: (number of FTP) 3 0.75. 6 Calculated as: (age at menopause-age at menarche-duration of OC use-cumulative duration of FTP), and entered into the model with a minus sign; further adjusted for menopausal status at recruitment and ever HRT use. 7 Calculated as: (age at menopause-age at menarche-duration of OC use-cumulative duration of FTP), and entered into the model with a minus sign; further adjusted for ever HRT use.…”

Section: Discussionmentioning

confidence: 99%

“…1,[4][5][6][7][8][9][10][11][12][13] For example, a collaborative reanalysis of 45 epidemiologic studies found the risk reduction afforded by OC use was evident for serous, endometrioid and clear cell, but not mucinous, tumors 13 and an analysis in the Ovarian Cancer Cohort Consortium (OCAC) found a positive association between body mass index (BMI) and risk of invasive endometrioid, mucinous and clear cell, but not high grade serous, tumors. 12 However, heterogeneous associations between BMI and EOC histologic subgroups have not been observed in all studies.…”

Section: What's New?mentioning

confidence: 99%

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Reproductive and hormone‐related risk factors for epithelial ovarian cancer by histologic pathways, invasiveness and histologic subtypes: Results from the EPIC cohort

Fortner

Ose

Merritt

et al. 2015

Intl Journal of Cancer

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Whether risk factors for epithelial ovarian cancer (EOC) differ by subtype (i.e., dualistic pathway of carcinogenesis, histologic subtype) is not well understood; however, data to date suggest risk factor differences. We examined associations between reproductive and hormone‐related risk factors for EOC by subtype in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Among 334,126 women with data on reproductive and hormone‐related risk factors (follow‐up: 1992–2010), 1,245 incident cases of EOC with known histology and invasiveness were identified. Data on tumor histology, grade, and invasiveness, were available from cancer registries and pathology record review. We observed significant heterogeneity by the dualistic model (i.e., type I [low grade serous or endometrioid, mucinous, clear cell, malignant Brenner] vs. type II [high grade serous or endometrioid]) for full‐term pregnancy (phet = 0.02). Full‐term pregnancy was more strongly inversely associated with type I than type II tumors (ever vs. never: type I: relative risk (RR) 0.47 [95% confidence interval (CI): 0.33–0.69]; type II, RR: 0.81 [0.61–1.06]). We observed no significant differences in risk in analyses by major histologic subtypes of invasive EOC (serous, mucinous, endometrioid, clear cell). None of the investigated factors were associated with borderline tumors. Established protective factors, including duration of oral contraceptive use and full term pregnancy, were consistently inversely associated with risk across histologic subtypes (e.g., ever full‐term pregnancy: serous, RR: 0.73 [0.58–0.92]; mucinous, RR: 0.53 [0.30–0.95]; endometrioid, RR: 0.65 [0.40–1.06]; clear cell, RR: 0.34 [0.18–0.64]; phet = 0.16). These results suggest limited heterogeneity between reproductive and hormone‐related risk factors and EOC subtypes.

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Section: Discussionmentioning

confidence: 99%

Section: What's New?mentioning

confidence: 99%

Reproductive and hormone‐related risk factors for epithelial ovarian cancer by histologic pathways, invasiveness and histologic subtypes: Results from the EPIC cohort

Fortner

Ose

Merritt

et al. 2015

Intl Journal of Cancer

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“…We also investigated whether the associations with height and BMI varied by several risk factors for ovarian cancer. Additionally, because particular histologic subtypes of ovarian cancer resemble different gynecologic tissue (39), behave different clinically, and may have genetic differences (40), we studied whether the associations differed by histologic subtype.…”

Section: Introductionmentioning

confidence: 99%

Height, Body Mass Index, and Ovarian Cancer: A Pooled Analysis of 12 Cohort Studies

Schouten

Rivera

Hunter

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

135

105

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Background: Although many studies have investigated the association between anthropometry and ovarian cancer risk, results have been inconsistent. Methods: The associations of height, body mass index (BMI), and ovarian cancer risk were examined in a pooled analysis of primary data from 12 prospective cohort studies from North America and Europe. The study population consisted of 531,583 women among whom 2,036 epithelial ovarian cancer cases were identified. To summarize associations, study-specific relative risks (RR) were estimated using the Cox proportional hazards model and then combined using a random-effects model. Results: Women with height z1.70 m had a pooled multivariate RR of 1.38 [95% confidence interval (95% CI), 1.16-1.65] compared with those with height <1.60 m. For the same comparison, multivariate RRs were 1.79 (95% CI, 1.07-3.00) for premenopausal and

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“…Whether the risk of other subtypes of ovarian cancer might also be influenced by cigarette smoking is less certain, as prior studies have not been uniform in their findings (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14).…”

mentioning

confidence: 99%

Cigarette smoking and risk of epithelial ovarian cancer

Rossing

Cushing‐Haugen

Wicklund

et al. 2007

Cancer Causes Control

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Histologic types of epithelial ovarian cancer: have they different risk factors?

Cited by 151 publications

References 64 publications

Reproductive and hormone‐related risk factors for epithelial ovarian cancer by histologic pathways, invasiveness and histologic subtypes: Results from the EPIC cohort

Reproductive and hormone‐related risk factors for epithelial ovarian cancer by histologic pathways, invasiveness and histologic subtypes: Results from the EPIC cohort

Height, Body Mass Index, and Ovarian Cancer: A Pooled Analysis of 12 Cohort Studies

Cigarette smoking and risk of epithelial ovarian cancer

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