Histologic Study of Depressed Acne Scars Treated with Serial High-Concentration (95%) Trichloroacetic Acid

YUG, ANTHONY; Lane, Joshua E.; Howard, Michael S.; Kent, David

doi:10.1097/00042728-200608000-00001

Cited by 9 publications

(16 citation statements)

References 5 publications

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“…Histologic examination of acne scars' 24hour status after application of 50% TCA revealed coagulative necrosis in the epidermis and necrosis of collagen in the dermis. Hematoxylin and eosin staining of pre-vs. post operative acne scars revealed apparent increased collagen in the treated scars, as expected (4). Further analysis with Masson trichrome and Verhoeff-van Gieson demonstrated increased collagen production and fragmentation of elastin fibers in the papillary dermis.…”

Section: Resultssupporting

confidence: 76%

CROSS technique: chemical reconstruction of skin scars method

Fabbrocini

Cacciapuoti

Fardella

et al. 2008

Dermatologic Therapy

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Skin scars remain a therapeutic challenge to dermatologists. Over the past several decades, numerous surgical techniques have been used to improve the appearance of scarring. The objective of this study is to evaluate the efficacy of a local application of a (50%) concentration of trichloroacetic acid (TCA) for the treatment of atrophic acne scars (grade 3 in Goodman classification), as opposed to the higher (90%) TCA concentration used in previous studies, in order to reduce adverse local effects. The primary goal was the resolution of acne or chickenpox scars. Secondary goals were physician and subject assessments of scar improvement. Fifty percent TCA was applied locally to atrophic scars in five patients. Three patients had treated scars on the face and two patients had treated scars on the back. Wooden applicators were used to apply TCA locally and the treatment was repeated at 4-week intervals for a total of three sessions. Digital photographic analysis of lesions supported clinical observations. Histologic examination was performed only on two samples of patients with treated scars on the back. Clinical examination revealed cosmetic improvements in both depth and appearance of skin scars. We believe that the 50% TCA CROSS can be an effective technique for the treatment of atrophic scars.

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Section: Resultssupporting

confidence: 76%

CROSS technique: chemical reconstruction of skin scars method

Fabbrocini

Cacciapuoti

Fardella

et al. 2008

Dermatologic Therapy

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“…1,[8][9][10] Improvement of acne scars after TCA CROSS occurs because of coagulative necrosis in the epidermis, necrosis of dermal collagen, and fragmentation of elastin fibers in the papillary dermis. 11 Our aim was to compare the efficacy of PCI (using Dermaroller) and high concentrated TCA CROSS as different therapeutic modalities for the treatment of atrophic acne scars. To our knowledge, there is no reported study comparing the efficacy of these techniques in the management of atrophic acne scars.…”

mentioning

confidence: 99%

Percutaneous Collagen Induction Versus Full-Concentration Trichloroacetic Acid in the Treatment of Atrophic Acne Scars

Leheta¹,

Tawdy²,

Hay³

et al. 2011

Dermatologic Surgery

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“…A variation of chemical peeling involving the use of 60% to 100% trichloroacetic acid, 84,85 termed the CROSS technique, has raised interest in the treatment of smaller ice pick ( Figure 7) and poral type scars, which have always proved a challenge. Basically, this modality scars the inside of the already cylindrical scar, making it cosmetically more appealing.…”

Section: Cross Techniquementioning

confidence: 99%