Histologic Studies of the Vasculature of the Anterior Optic Nerve

Lieberman, Marc F.; Maumenee, A. Edward; Green, W. Richard

doi:10.1016/0002-9394(76)90489-x

Cited by 192 publications

(64 citation statements)

References 33 publications

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“…8,46 Our CDI revealed a significant increase in the RI in the CRA which supplies the surface nerve fibre layer and very few or none in the prelaminar region of the optic nerve. 48,49 These data were significantly correlated with the decrease in thickness in the inferior quadrant of RNFL. Moreover, we found an increased RI in the PCAs supplying the vessels that distribute blood to the laminar and retrolaminar portion of the optic nerve.…”

Section: Discussionmentioning

confidence: 78%

Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension

Cellini

Bernabini

Carbonelli

et al. 2006

Eye

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Purpose To study in ocular hypertension (OH) the retinal nerve fibre layer (RNFL) with optical coherence tomography (OCT) and the neuronal function with frequency-doubling technology (FDT) to assess which of the two methods was more sensitive in detecting early glaucomatous damage. Furthermore, a colour Doppler imaging (CDI) of the optic nerve was carried out to highlight any correlation with RNFL thickness and FDT abnormality. Materials and methods We enrolled 28 ocular hypertensive patients who underwent OCT of the RNFL and FDT. Moreover, we performed a CDI of the ophthalmic artery (OA), central retinal artery (CRA), and posterior ciliary arteries (PCAs). Results The patients with OH following OCT revealed a significant thinning in the RNFL as compared to the control group only in the inferior quadrant: 122.250714.091 vs 131.750710.729 lm (Po0.045). As regards FDT, there was a significant difference between the two groups only for pattern standard deviation (PSD): 3.87371.488 vs 1.93870.704 dB (Po0.044). In OH and in the control group, CDI resistance index (RI) in the OA was 0.76870.012 vs 0.74570.019 (Po0.022), in the CRA was 0.6670.012 vs 0.64570.019 (Po0.032), and in PCAs was 0.67370.039 vs 0.62270.012 (Po0.037). The OCT had a sensitivity of 83% but only in the inferior RNFL quadrant. The FDT-PSD revealed a sensitivity of 85%. Conclusions Both FDT and OCT detect early glaucomatous damage with a slightly superior sensitivity of FDT vs OCT. The CDI measurements suggest that circulatory abnormalities may have a role in the development of OCT and FDT damage.

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Section: Discussionmentioning

confidence: 78%

Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension

Cellini

Bernabini

Carbonelli

et al. 2006

Eye

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“…In fluorescein angiography, zone Beta did not fluoresce in the choroidal filling phase (Hayreh & Walker 1967). Because the prelaminar and laminar portions of the optic nerve head receive their main blood supply from the peripapillary choroid via branches of short posterior ciliary arteries (Hayreh 1969;Lieberman et al 1976;Anderson & Braverman 1976;Onda et al 1995), the absence or obliteration of centripetal branches in the area of peripapillary atrophy may possibly result in an environment that causes vascular insufficiency in that segment of the optic nerve head.…”

Section: Discussionmentioning

confidence: 99%

Disc hemorrhage and peripapillary atrophy in apparently healthy subjects

Sugiyama

Tomita

Kawase

et al. 1999

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: We estimated the prevalence of disc hemorrhage and peripapillary atrophy in apparently healthy subjects. Methods: We reviewed consecutive plain color fundus photographs of 12,140 eyes of 6,070 subjects (male/femaleΩ4,079/1,991) who visited a health consultation center. Results: We analyzed 11,934 eyes of 5,967 subjects with good quality of photographs. Disc hemorrhage was found in 36 eyes of 35 subjects (0.6%). The prevalence of disc hemorrhage was significantly greater in women 60 years of age or older (Fisher's exact test, pΩ0.0004). The prevalence of peripapillary atrophy (zone Beta, zone Alpha), and suspected glaucomatous excavation in eyes with disc hemorrhage was 66.7%, 86.1% and 25.0%, respectively, and significantly greater than that (29.1%, 52.9% and 1.7%) in eyes without disc hemorrhage (Fisher's exact test, p∞0.0001). Conclusions: Disc hemorrhage is more frequent in women over 60 years of age and is significantly associated with peripapillary atrophy in otherwise apparently healthy Japanese people.

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“…The optic nerve vascular supply varies depending on the region. 10,[59][60][61][62][63][64][65] The superficial nerve fiber layer is supplied principally from the arterioles in the adjacent retina, which derive from the central retinal artery. The central retinal artery usually does not contribute to either the prelaminar or laminar region, although it may contribute minimally to the retrolaminar region.…”

Section: Optic Nerve Vascular Anatomy and Physiologymentioning

confidence: 99%

Ischemic model of optic nerve injury

Cioffi

2006

American Journal of Ophthalmology

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Histologic Studies of the Vasculature of the Anterior Optic Nerve

Cited by 192 publications

References 33 publications

Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension

Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension

Disc hemorrhage and peripapillary atrophy in apparently healthy subjects

Ischemic model of optic nerve injury

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