Histologic Severity of Nonalcoholic Fatty Liver Disease Associates with Reduced Bone Mineral Density in Children

Khan, Soofia; Kalkwarf, Heidi J.; Hornung, Lindsey; Siegel, Robert; Arce‐Clachar, Ana Catalina; Sheridan, Rachel; Ippisch, Holly M.; Xanthakos, Stavra A.

doi:10.1007/s10620-022-07563-z

Cited by 1 publication

(1 citation statement)

References 39 publications

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“…An Italian case-control study of 44 obese children diagnosed with NAFLD revealed a significantly lower BMD Z-score in the lumbar spine in these children vs. children without NAFLD. In a cohort of children with obesity and NAFLD (a liver biopsy was performed to diagnose NASH and the stage of liver fibrosis), it was shown that children with NASH had a significantly lower BMD Z-score of the lumbar vertebrae, compared with children with simple steatosis, which implied the role of mild inflammation in the process of bone loss [17]. Similar results were obtained in another study in 38 children with biopsy-confirmed NAFLD.…”

Section: Nafld and Decreased Bone Mineral Density: Some Epidemiologic...supporting

confidence: 71%

Non-Alcoholic Fatty Liver Disease and Bone Tissue Metabolism: Current Findings and Future Perspectives

Drapkina,

Elkina,

Sheptulina

et al. 2023

IJMS

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Non-alcoholic fatty liver disease (NAFLD) is reaching epidemic proportions worldwide. Moreover, the prevalence of this liver disease is expected to increase rapidly in the near future, aligning with the rise in obesity and the aging of the population. The pathogenesis of NAFLD is considered to be complex and to include the interaction between genetic, metabolic, inflammatory, and environmental factors. It is now well documented that NAFLD is linked to the other conditions common to insulin resistance, such as abnormal lipid levels, metabolic syndrome, and type 2 diabetes mellitus. Additionally, it is considered that the insulin resistance may be one of the main mechanisms determining the disturbances in both bone tissue metabolism and skeletal muscles quality and functions in patients with NAFLD. To date, the association between NAFLD and osteoporosis has been described in several studies, though it worth noting that most of them included postmenopausal women or elderly patients and originated from Asia. However, taking into account the health and economic burdens of NAFLD, and the increasing prevalence of obesity in children and adolescents worldwide, further investigation of the relationship between osteopenia, osteoporosis and sarcopenia in NAFLD, including in young and middle-aged patients, is of great importance. In addition, this will help to justify active screening and surveillance of osteopenia and osteoporosis in patients with NAFLD. In this review, we will discuss various pathophysiological mechanisms and possible biologically active molecules that may interplay between NAFLD and bone tissue metabolism.

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Section: Nafld and Decreased Bone Mineral Density: Some Epidemiologic...supporting

confidence: 71%

Non-Alcoholic Fatty Liver Disease and Bone Tissue Metabolism: Current Findings and Future Perspectives

Drapkina,

Elkina,

Sheptulina

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

Histologic Severity of Nonalcoholic Fatty Liver Disease Associates with Reduced Bone Mineral Density in Children

Cited by 1 publication

References 39 publications

Non-Alcoholic Fatty Liver Disease and Bone Tissue Metabolism: Current Findings and Future Perspectives

Non-Alcoholic Fatty Liver Disease and Bone Tissue Metabolism: Current Findings and Future Perspectives

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