Histologic, Metabolic, and Inflammatory Changes in the Liver of High-fat  Diet-induced Obese Rats before and after Vitamin D Administration

Yaghchiyan, Mahdi; Roshangar, Leila; Farhangi, Mahdieh Abbasalizad; Mesgari‐Abbasi, Mehran; Rafiei, Leila; Shahabi, Parviz

doi:10.18502/ijaai.v18i4.1418

Cited by 5 publications

(6 citation statements)

References 25 publications

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“…The results of changes in food intake, body weight and serum vitamin D concentrations had been reported in our previous work (Hajiluian et al, 2017;Nameni et al, 2017;Yaghchiyan et al, 2019). Briefly, food intake in all of groups increased significantly until the administration of vitamin D, whereas after vitamin D administration, in ND and HFD groups, food intake decreased significantly (P < 0.001, Figure 1).…”

Section: Changes In Food Intake Body Weight and Serum Vitamin D Concentrationssupporting

confidence: 76%

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Histological, metabolic, and inflammatory changes in the renal tissues of high-fat diet-induced obese rats after vitamin D supplementation

Avestaei

Yaghchiyan

Alihemmati

et al. 2020

NFS

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Purpose Obesity is a major risk factor for chronic renal fibrosis and kidneys’ structural and inflammatory impairments. This study aims to examine the possible therapeutic effects of vitamin D supplementation against renal inflammatory and kidney’s structural fibrosis and degeneration. Design/methodology/approach Forty male Wistar rats were divided into two groups for 16 weeks: normal diet (ND) and high-fat diet (HFD); then, each group was subdivided into two groups including ND, ND + vitamin D and HFD, HFD + vitamin D. Vitamin D supplementation was done for five weeks at 500 IU/kg dosage. Renal tissue concentrations of tumor necrosis factor (TNF)-α, interleukin 6, interleukin 1 beta, monocyte chemoattractant protein (MCP)-1 and transforming growth factor-beta (TGF-β), serum values of lipids, markers of glucose homeostasis and urea, creatinine and uric acid and renal tissue histological and structural changes were determined. Findings HFD feeding caused remarkable histological and structural changes including higher TNF-α, MCP-1 and TGF-β concentrations in renal tissues of rats, whereas vitamin D has potent anti-inflammatory effects (P = 0.036, 0.047 and 0.02, respectively). Vitamin D administration also reduced urea and uric acid concentrations (P = 0.023 and 0.049, respectively). Moreover, vitamin D reduced glomerulomegaly, reduced lipid accumulation and limited dilated Bowman’s space in rats and improved glycemic status by increasing insulin (P = 0.04) and reducing insulin resistance (P = 0.006). Research limitations/implications The current study has some limitations. It was better to measure the level of inflammatory cytokines’ expression in the kidney tissues. Additionally, the measurement of baseline values of inflammatory cytokines was not possible because of the possibility of animals’ drop-out. Practical implications According to the study findings, vitamin D treatment in the current report showed a significant therapeutic role in reducing inflammation, improving glycemic and lipid abnormalities and structural and histological modifications in renal tissues of rats. These findings have a great value because after confirming in a human model, vitamin D can be suggested as a potential therapeutic tool in clinical practice. Social implications After being confirmed by other animal or human researches, the results of the current work could have great social implications by reducing the prevalence of obesity-related renal complications and highlighting the beneficial roles of vitamin D. Originality/value To the best of the authors’ knowledge, this is the first study to investigate the histological and inflammatory changes in the kidneys and metabolic parameters in the HFD induced rats and also clarified the therapeutic roles of vitamin D in ameliorating the inflammatory, histological, metabolic and functional changes in the kidneys of obese rats.

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Section: Changes In Food Intake Body Weight and Serum Vitamin D Concentrationssupporting

confidence: 76%

“…The protocol of the study has been explained before (Hajiluian et al, 2017;Nameni et al, 2017;Yaghchiyan et al, 2019). A brief explanation of procedures and methods is as follows:…”

Section: Methodsmentioning

confidence: 99%

Histological, metabolic, and inflammatory changes in the renal tissues of high-fat diet-induced obese rats after vitamin D supplementation

Avestaei

Yaghchiyan

Alihemmati

et al. 2020

NFS

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“…(Zhou et al, 2018) MCP1 can activate TGF-b production and increase the fibrogenic potential by stimulating TGF-b and collagen synthesis. (Yaghchiyan et al, 2019) Further, MCP-1 was recently reported to enhance TGF-b signaling via increasing expression of MMP-9. (Youn et al, 2019) The silence of NOX-2 in cardiomyocyte can attenuate hypoxia-induced oxidative stress and apoptosis indicating that NOX-2 may cause cardiac dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Sex Effect on Cardiac Damage in Mice With Experimental Autoimmune Encephalomyelitis

Yuan

et al. 2021

ASN Neuro

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Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system. Recent clinical study suggested that MS patient exhibited acute heart failure. Further, 12-lead electrocardiographic study showed a longer QTc interval in both MS patient and experimental autoimmune encephalomyelitis (EAE) Lewis rat. However, there is limited study regarding the effect of sex on cardiac injury in EAE. To our knowledge, sex effect on cardiac damage in mice with EAE has not yet been published. Herein, we examined the role of the immune system in mediating cardiac dysfunction after EAE in female and male mice. Neurological function was subsequently evaluated and cardiac function was assessed by echocardiography at multiple time points after EAE. EAE mice exhibited severe neurological deficit and significant cardiac dysfunction, including decreased left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) at 1 and 2 months after EAE induction. Meanwhile male EAE presented increased expression of the oxidative stress (e.g., nicotinamaide adenine dinucleotide phosphate oxidase-2; NOX-2) in heart, as well as cardiac hypertrophy, increased left ventricle (LV) mass and more severe cardiac fibrosis compared with male control mice. In addition, male EAE mice showed significantly increased cardiac canonical inflammatory mediator (e.g., monocyte chemoattractant protein-1; MCP-1, transforming growth factor-β; TGF-β and toll-like receptor 2; TLR-2) compared with female EAE mice at 2 months after EAE induction. In conclusion, EAE increases inflammatory factor expression and aggravates cardiac dysfunction in male mice compared with female mice, which may contribute to different cardiac outcome in EAE mice.

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“…It is also considered as a chronic low-grade infl ammatory disorder because there is an extreme production of pro-infl ammatory molecules in obese people [9]. The liver is most susceptible to these cytokines by causing liver damage [10]. Moreover, insulin resistance and type 2 diabetes are prone to develop in people who are obese.…”

Section: Discussionmentioning

confidence: 99%

Decrease of microglia and fatty liver in obese mice by germinated Sang-Yod rice

Wangpradit¹,

Prom-in²,

Kumar³

et al. 2020

Glob J Obes Diabetes Metab Syndr

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Histologic, Metabolic, and Inflammatory Changes in the Liver of High-fat Diet-induced Obese Rats before and after Vitamin D Administration

Cited by 5 publications

References 25 publications

Histological, metabolic, and inflammatory changes in the renal tissues of high-fat diet-induced obese rats after vitamin D supplementation

Histological, metabolic, and inflammatory changes in the renal tissues of high-fat diet-induced obese rats after vitamin D supplementation

Sex Effect on Cardiac Damage in Mice With Experimental Autoimmune Encephalomyelitis

Decrease of microglia and fatty liver in obese mice by germinated Sang-Yod rice

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