Histologic Malignancy Grading in Invasive Squamous Cell Carcinoma of the Vulva

Abstract

A preliminary report on a histologic malignancy grading of vulvar carcinoma is presented. A retrospective histologic study of 40 vulvar carcinoma cases stage I and II (TNM-system) with a minimum five-year follow-up was carried out and correlated to the course of the disease. Morphologic criteria characterizing the tumor cell population, as well as the tumor-host relationship, were examined and scored. The scores obtained could be divided into three groups that correlated well with the clinical outcome. The low-score group had no metastases or recurrence, whereas 82% of the high-score group had both metastases and fatalities. Depth of invasion was found to have a strong correlation to clinical outcome. A more accurate morphologic malignancy grading of such carcinomas could lead to a more individual and often less radical treatment plan.

Synthesis and characterization of a positive‐working, aqueous‐base‐developable photosensitive polyimide precursor

“…For the current study, all slides of tumors were reviewed by an experienced gynecopathologist (H.H.). The tumors were reexamined for: greatest tumor dimension (mm), depth of invasion (with a calibrated micrometer, depth of invasion was measured in mm from the stratum granulosum to the deepest point of the tumor), degree of differentiation (good, moderate, or poor; when the percentage of undifferentiated cells was < 5%, the tumor was scored as well differentiated; tumors with 5–50% undifferentiated cells were scored moderately differentiated; and tumors with > 50% undifferentiated cells were scored poorly differentiated),25 and the presence of lymph/vascular invasion (defined as the presence of tumor emboli in endothelial‐lined spaces). In Group I, only sections of the margins from the specimen were taken to exclude tumor in these margins.…”

Vulvar carcinoma

“…The tumors were reexamined for: greatest tumor dimension (mm), depth of invasion (with a calibrated micrometer, depth of invasion was measured in mm from the stratum granulosum to the deepest point of the tumor), degree of differentiation (good, moderate, or poor; when the percentage of undifferentiated cells was Ͻ 5%, the tumor was scored as well differentiated; tumors with 5-50% undifferentiated cells were scored moderately differentiated; and tumors with Ͼ 50% undifferentiated cells were scored poorly differentiated), 25 and the presence of lymph/vascular invasion (defined as the presence of tumor emboli in endothelial-lined spaces). In Group I, only sections of the margins from the specimen were taken to exclude tumor in these margins.…”

Stage I Squamous Cell Carcinoma of the Vulva

“…In 77 patients the prognoses were estimated from properties of the tumour cell population: structure, differentiation into cell type, nuclear polymorphism, mitosis, and the tumour host relationship: mode of invasion, stage of invasion, vascular invasion, (lymphotic) cellular response, were graded according to a pointscore system used for squamous cell carcinoma of the larynx (13, 14), the palate (8), the gingiva (28), the uterine cervix (25) and the vulva (15). Each parameter was given 1 to 3 points resulting in a total of 8 to 24 points in an increasing grade of malignancy.…”