Histologic investigations on 33 retrieved Nobelpharma implants

Albrektsson, Tomas; Eriksson, Anders R.; Friberg, Bertil; Lekholm, Ulf; Lindahl, Lars; Nevins, M; Oikarinen, Valle J.; Roos, J; Sennerby, Lars; Åstrand, Per

doi:10.1016/0267-6605(93)90021-x

Cited by 90 publications

(51 citation statements)

References 5 publications

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“…Histological studies of retrieved intraoral implants in man have been published for different implant systems [12][13][14][15][16]. Most of the articles include a limited number of samples, providing only a qualitative evaluation [17].…”

Section: Discussionmentioning

confidence: 99%

Microradiographic Study of Retrieved Craniofacial Osseointegrated Implants

Granström¹

1999

ORL

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In this study 18 screw-shaped extraoral osseointegrated implants retrieved from 10 patients were analyzed. The reasons for retrieval were: unexplained pain (n = 4); inability to cope with the implants (n = 2); fracture of the central screw (n = 2); skin penetration problems (n = 1), and trauma (n = 1). Retrieved implants were trephined with a border of surrounding bone, fixed, embedded in epon plastic, ground and processed for microradiography. The study group comprised 6 males and 4 females with a mean age of 53.4 (range 9–81) years. All implants were clinically stable at the time of removal, and the mean osseointegration time was 3 (range 1–5) years. Six implants were removed from the temporal bone, 5 from the frontal bone, and 7 from the maxilla. By microradiography, it was found that all retrieved implants were surrounded by a lamellar type of bone with haversian systems, vascular channels, osteocyte lacunae, and in some specimens regeneration and resorption areas. Bone metal contact was estimated to vary between 27 and 83%. Bone metal contact was lower in the frontal bone compared to the temporal bone or maxilla, and was further reduced after preoperative irradiation. Longer osseointegration time increased bone metal contact, as did increased age up to 60 years. It is concluded that extraoral osseointegrated implants in humans may integrate morphologically as well as clinically. By microradiography it was possible to define bone metal contact in the region of implant installation.

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Section: Discussionmentioning

confidence: 99%

Microradiographic Study of Retrieved Craniofacial Osseointegrated Implants

Granström¹

1999

ORL

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“…The high success rate of titanium implant treatments depends on the reparative capacity of the host bone to establish intimate contact with the implant surface [1].…”

Section: Introductionmentioning

confidence: 99%

Local release of magnesium from mesoporous TiO 2 coatings stimulates the peri-implant expression of osteogenic markers and improves osteoconductivity in vivo

et al. 2014

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“…Albrektsso n et al suggested that osseointegration corresponded to approximately 60% bone contact for titanium implants 26) . Thus, we conclude that Laser-Ti provided sufficient BIC for use in dental clinics.…”

Section: Discussionmentioning

confidence: 99%

Bone and Gingival Connective Tissue Responses towards Nanosecond-Pulsed Laser-Treated Titanium Implants

Fukayo

Amemiya

Nakaoka

et al. 2016

J. Hard Tissue Biology.

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:The aim of this study was to evaluate bone and gingival connective tissue responses towards nanosecond-pulsed laser-treated titanium implants. A Nd:YVO 4 nanosecond-pulse laser with a defocus technique was used to modify the surfaces of two types of cylindrical titanium implants. One had a 3.5 mm diameter and 7.0 mm length ( 3.5 Ti) to assess rabbit bone responses; the other a 1.0 mm diameter and 4.5 mm length ( 1.0 Ti) to assess rat gingival connective tissue responses. Laser-treated titanium implants, a 3.5 Laser-Ti and 1.0 Laser-Ti, were obtained by defocus irradiation. Collagen immobilized 1.0Laser-Ti ( 1.0 Coll/Laser-Ti) implants were obtained by a tresyl chloride-activated method. Laser-Ti surfaces had micro-scale roughened oxide layers and parallel arranged grooves. Sa (average roughness) and Sdr (interfacial area ratio) values of the Laser-Ti were significantly higher than those of Ti (titanium) implants (p<0.05). The 3.5 implants were implanted into the bone defects of rabbits to evaluate bone responses and 1.0 implants were implanted into the extracted sockets of rat maxilla to evaluate gingival connective tissue responses. After implantation periods, the specimens were excised and non-decalcified thin sections prepared to evaluate histological responses. After 12 weeks of implantation in the rabbit experiments, bone-to-implant contact for the Laser-Ti implants was significantly higher than for the Ti in both tibia and femoral condyle (p<0.05). Improved attachment of gingival connective tissue to the implant surface was observed for Laser-Ti and Coll/Laser-Ti in the rat maxilla. Polarized light microscopy showed perpendicular rod-like attachments of gingival collagen fibers on the Laser-Ti and Coll/ Laser-Ti implant surfaces. Ti implants had no discernible attachments with gingival connective tissue along the implant surface. In conclusion, nanosecond-pulsed laser treatment with a defocus technique produced roughened titanium surfaces with parallel grooves and micro-roughened asperities. Laser treatment of implants resulted in improved bone responses and attachment of gingival connective tissue.

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Histologic investigations on 33 retrieved Nobelpharma implants

Cited by 90 publications

References 5 publications

Microradiographic Study of Retrieved Craniofacial Osseointegrated Implants

Microradiographic Study of Retrieved Craniofacial Osseointegrated Implants

Local release of magnesium from mesoporous TiO 2 coatings stimulates the peri-implant expression of osteogenic markers and improves osteoconductivity in vivo

Bone and Gingival Connective Tissue Responses towards Nanosecond-Pulsed Laser-Treated Titanium Implants

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