Histologic evidence of inflammation and risk of placental abruption

Nath, Carl; Ananth, Cande V.; Smulian, John C.; Shen‐Schwarz, Susan; Kaminsky, Lillian

doi:10.1016/j.ajog.2007.06.012

Cited by 90 publications

(72 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Decidual haemorrhage was generally accepted as an acute event; however, histological evaluation of the vasculopathy accompanying decidual haemorrhage provides compelling evidence that the damage is frequently chronic (Salafia et al 1995, Elsasser et al 2010. Placental abruption has been shown to be associated with inflammatory lesions of the placenta, in particular at preterm gestations (Nath et al 2007) and interestingly a strong association has been noted between severe CA and abruption at term (Nath et al 2007). This suggests that inflammatory pathways are common to both infection and decidual haemorrhage.…”

Section: Figurementioning

confidence: 99%

Myometrial cytokines and their role in the onset of labour

Sivarajasingam

Imami

Johnson

2016

Journal of Endocrinology

View full text Add to dashboard Cite

Human labour is an inflammatory event, physiologically driven by an interaction between hormonal and mechanical factors and pathologically associated with infection, bleeding and excessive uterine stretch. The initiation and communicators of inflammation is still not completely understood; however, a key role for cytokines has been implicated. We summarise the current understanding of the nature and role of cytokines, chemokines and hormones and their involvement in signalling within the myometrium particularly during labour.

show abstract

Section: Figurementioning

confidence: 99%

Myometrial cytokines and their role in the onset of labour

Sivarajasingam

Imami

Johnson

2016

Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…For example, vitamins may enhance maternal nutritional status and immunity during pregnancy, which may reduce the risk of intrauterine infections [28]. This hypothesis may be particularly important for placental abruption, as intrauterine infections and inflammation have been identified as one of the pathways by which placental abruption occurs [29][30][31]. Additionally, vitamins may positively impact birth outcomes through the improvement of maternal hematologic status, a hypothesis that may be particularly relevant to our study findings.…”

Section: Discussionmentioning

confidence: 84%

Maternal pre-gravid body weight and risk for placental abruption among twin pregnancies

Aliyu¹,

Alio²,

Lynch³

et al. 2009

DJMF

View full text Add to dashboard Cite

show abstract

“…Drugs of abuse may increase maternal plasma viral load directly by: a promoting HIV replication in monocyte/macrophages; b increasing the expression of CCR5 receptors and decreasing the expression of their ligands (CCR5L); c increasing the expression of CXCR4 receptors; and d increasing the expression of DC-SIGN. Drugs of abuse may also increase maternal viral load indirectly by promoting HIV mutation through non-adherence to HAART and by impairing the efficacy of HAART through drug-drug interaction (HAART-DA) which has been linked to placental inflammation, chorioamnionitis (Nath et al 2007). In addition, cocaine exposure during pregnancy was associated with chronic villus hemorrhage and villus edema (Mooney et al 1998).…”

Section: Placental Injurymentioning

confidence: 98%

Mother-to-Child Transmission (MTCT) of HIV and Drugs of Abuse in Post-Highly Active Antiretroviral Therapy (HAART) Era

Purohit

Rapaka

Shurtleff

2010

J Neuroimmune Pharmacol

View full text Add to dashboard Cite

In the pre-highly active antiretroviral therapy (HAART) era, prenatal "vertical" mother-to-child transmission (MTCT) of HIV was about 25% and exposure of pregnant mothers to drugs of abuse (illicit drugs and tobacco smoking) was a significant contributory factor of MTCT. However, with the introduction of HAART, the rate of MTCT of HIV has decreased to less that 2%. But, it is estimated that currently about 5.1% of pregnant women use illicit drugs and 16.4% smoke tobacco. The residual prevalence of MTCT is of concern and may be related to this continued prevalence of substance use among pregnant mothers. In this report, we review and present evidence that supports the hypothesis that drugs of abuse do have the potential to increase MTCT of HIV in the presence of HAART. Exposure to drugs of abuse during pregnancy may increase MTCT of HIV through a variety of mechanisms that are addressed in detail including possible damage to the placenta, induction of preterm birth, and increasing maternal plasma viral load though a variety of putative mechanisms such as: (a) promoting HIV replication in monocyte/macrophages; (b) increasing the expression of CCR5 receptors; (c) decreasing the expression of CCR5 receptor ligands; (d) increasing the expression of CXCR4 receptors; (e) increasing the expression of DC-SIGN; (f) impairing the efficacy of HAART through drug-drug interaction; and (g) promoting HIV mutation and replication through non-adherence to HAART.

show abstract

Histologic evidence of inflammation and risk of placental abruption

Cited by 90 publications

References 17 publications

Myometrial cytokines and their role in the onset of labour

Myometrial cytokines and their role in the onset of labour

Maternal pre-gravid body weight and risk for placental abruption among twin pregnancies

Mother-to-Child Transmission (MTCT) of HIV and Drugs of Abuse in Post-Highly Active Antiretroviral Therapy (HAART) Era

Contact Info

Product

Resources

About