Histologic Evaluation of Neck Dissection Specimens

Gillies, Elizabeth M.; Luna, Mario A.

doi:10.1016/s0030-6665(05)70085-2

Cited by 21 publications

(15 citation statements)

References 48 publications

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“…This may be important, because the recommended method of identification of nodes by dissection 29 may fail to identify micrometastases. The mean size of node metastases in head and neck cancer is 11.6 mm, 30 and about half the involved nodes are less than 10 mm in diameter.…”

Section: Methodsmentioning

confidence: 99%

Surgical treatment of cervical node metastases from squamous carcinoma of the upper aerodigestive tract: Evaluation of the evidence for modifications of neck dissection

Buckley¹,

Feber²

2001

Head & Neck

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Section: Methodsmentioning

confidence: 99%

Surgical treatment of cervical node metastases from squamous carcinoma of the upper aerodigestive tract: Evaluation of the evidence for modifications of neck dissection

Buckley¹,

Feber²

2001

Head & Neck

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“…Estes resultados sugerem que pacientes com lesões extensas de boca, oro e hipofaringe poderiam se beneficiar de recursos diagnósticos não-invasivos que investigam a presença de metastatização linfática cervical oculta. Como o presente estudo empregou análise histopatológica convencional, um número significativo de micrometástases podem não ter sido identificadas, mas o significado clínico das micrometástases nos carcinomas epidermóides de cabeça e pescoço ainda não foi estabelecido 14,15,16,17 . Genericamente pode-se dizer que os esvaziamentos seletivos são procedimentos adequados para o estadiamento e proporcionam a remoção da maioria das metástases sub-clínicas nos pacientes com carcinoma epidermóide das vias aerodigestivas superiores 18,19 .…”

Section: Discussionunclassified

Metastatização linfática oculta no carcinoma epidermóide das vias aerodigestivas superiores

Amar

Carvalho

Rapoport

2002

Rev. Bras. Otorrinolaringol.

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Introdução:Os esvaziamentos cervicais eletivos são procedimentos para identificar metástases cervicais ocultas em câncer de cabeça e pescoço. Forma de Estudo: Clínico retrospectivo. Objetivo: Avaliar a metastatização linfática oculta em pacientes com carcinoma epidermóide das vias aero-digestivas superiores. Material e Método: Foram avaliados, retrospectivamente 428 pacientes submetidos a esvaziamento cervical eletivo entre os anos de 1977 e 1996. Foi analisada a incidência de casos falsos-negativos (pN+) e sua relação com o tamanho (estádio T) e sítio anatômico do tumor primário, graduação histológica, sexo e faixa etária. Também foram avaliadas as cadeias linfonodais. Resultados: Metástases linfonodais ocultas foram diagnosticadas em 32% dos pacientes, sendo 26% nos tumores de laringe, 31% na orofaringe, 36% na cavidade oral e 40% na hipofaringe. Houve preponderância de metástases nos níveis II e III. Apenas os tumores de cavidade oral apresentaram metastatização significativa para o nível I (14%). As metástases ocultas acometeram um linfonodo em 14% e vários em 18% dos pacientes. O estadiamento T se relacionou com a metastatização oculta apenas nos tumores de laringe. Conclusões: Os níveis linfáticos II e III foram os mais afetados para as lesões da faringe e laringe, e o nível I para a cavidade oral, enquanto que os fatores de risco (idade, sexo e o grau de diferenciação histológica) não foram determinantes significativos de metástases ocultas.

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“…As a rule, lymph node micrometastases (< 10 mm) cannot be detected with imaging. Thus, anatopathological analysis of cervical lymph node dissection is the reference method to diagnose cervical node metastases (13)(14)(15)(16) …”

Section: Histologymentioning

confidence: 99%

Lymph Node Involvement In Upper Aerodigestive Tract Cancers - A Clinical Study at Specialities University Hospital of Rabat

Borki

Elayoubi

Bencheikh

et al. 2014

IJMS

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Introduction: Cervical lymph node involvement has a major impact on prognosis and treatment decisions in patients with upper aerodigestive tract (UADT) cancer. Objective: The aim of this study was to assess the incidence and pattern of cervical lymph node (LN) metastases in cancers of the upper aerodigestive tract Methods: This prospective study was conducted by the Department of ENT and Maxillofacial Surgery at Specialities University Hospital of Rabat, collecting data between October 2009 and December 2011. Lymph nodes were counted, clinically and radiologically localized, excised, then studied histologically. Results: During this period, 106 patients have been treated surgically with a recent diagnosis of UADT cancer. The average age of our patients was 55±13.3 years, while male/female ratio was 3.5 to 1. More than half of our patients were operated with cancer of the larynx (58.5%, n=62); 27.4% (n=29) of patients suffered from oral cavity cancer and 14.2% (n=15) had cancer of the hypopharinx. Cervical lymph node invasion was estimated at 31.2% clinically, and 38.7% radiologically and histologically, distributed in different sites. Although the percentage of the invasion is almost similar clinically, radiologically and histologically, the high number of false positives and true negatives according to clinical and radiological exams confirms that specificity and sensitivity of these two exams is still poor compared to histology. Conclusion: Thus, cervical metastases have to be diagnosed histologically. Moreover, the low percentage of lymph node invasions in the case of a UADT cancer suggests that the use of sentinel lymph node technique could be important, as it has been validated for small T1T2N0 tumors in the oral cavity. Further studies are needed to confirm its validity in case of other UADT tumor types.

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Histologic Evaluation of Neck Dissection Specimens

Cited by 21 publications

References 48 publications

Surgical treatment of cervical node metastases from squamous carcinoma of the upper aerodigestive tract: Evaluation of the evidence for modifications of neck dissection

Surgical treatment of cervical node metastases from squamous carcinoma of the upper aerodigestive tract: Evaluation of the evidence for modifications of neck dissection

Metastatização linfática oculta no carcinoma epidermóide das vias aerodigestivas superiores

Lymph Node Involvement In Upper Aerodigestive Tract Cancers - A Clinical Study at Specialities University Hospital of Rabat

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