Histologic Evaluation of Furcation Perforation Treated with Mineral Trioxide Aggregate and Bioaggregate

Hassanien, Ehab; Abu‐Seida, Ashraf M.; Hashem, Ahmed Abdel Rahman; Khanbash, Salah S.

doi:10.3923/ajas.2015.148.156

Cited by 15 publications

(18 citation statements)

References 22 publications

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“…During treatment of FP, using of an ideal repair material is an important factor for good prognosis. The FP repair material should have the abilities of good sealing and induction of new hard tissue [3,4]. This study compared the BD against the MTA as a FP repair material.…”

Section: Discussionmentioning

confidence: 99%

“…The data were collected in table (2) and figures (2)(3)(4). Both positive and negative control exhibited zero score in the new hard tissue formation (Figure 4).…”

Section: Immunohistochemical Findingsmentioning

confidence: 99%

“…Furcation perforation (FP) may occur throughout the procedure of endodontic access opening as a result of badly directed bur, or during post space preparation and localization of the calcified canals [1]. 3 The prognosis of FP depends mainly upon its size, site, the duration between the defect creation and repair, and the degree of periodontal damage. Therefore, immediate therapy using suitable filling material is essential to avoid the complications, and to enhance favorable prognosis [2].…”

Section: Introductionmentioning

confidence: 99%

“…The ideal filling material used for treatment of the FP should be able to seal the defect completely and enhance the new hard tissue formation. Numerous filling materials have been used for FP repair such as; MTA, Bioaggregate, Biodentine, platelet rich plasma, platelet rich fibrin and others [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…The MTA is commonly applied FP repair material because it has good biocompatibility and sealing ability as well as low bacterial leakage and cytotoxicity [7]. However, MTA has few disadvantages like long setting time (3h), less applicability and expensiveness [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

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Immunohistochemical Analysis of Biodentine Versus MTA in Repair of Experimental Furcation Perforation

Badr¹,

Abu‐Seida²,

Hashem³

et al. 2020

Preprint

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This study compared the Biodentine (BD) and MTA in repair of furcation perforation (FP) in a dog model in terms of inflammatory cell count and new hard tissue formation through histological and immunohistochemical evaluations. Ninety six teeth in six adult mongrel dogs were divided according to the time of repair into two groups (48 teeth/3 dogs each); immediate and delayed repair of the induced FP. Each group was divided into three subgroups (16 teeth each) according to the evaluation periods; 1, 2, and 3 months. Each subgroup was further subdivided into four subdivisions according to the material used; MTA (6 teeth), Biodentine (6 teeth), negative control (2 teeth) and positive control (2 teeth). In experimental and positive control samples, the teeth were instrumented and obturated then, a FP was performed. The perforations were sealed according to the groups and subdivisions. Histopathology and immunohistochemical analysis using Osteonectin antibodies were performed for assessment of the inflammatory cell count and new hard tissue formation. In all groups and subgroups, there were no significant differences between MTA and BD in the inflammatory cell count and new hard tissue formation (P>0.05). Biodentine can alternate the MTA as a FP repair material.

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Section: Discussionmentioning

confidence: 99%

“…The data were collected in table (2) and figures (2)(3)(4). Both positive and negative control exhibited zero score in the new hard tissue formation (Figure 4).…”

Section: Immunohistochemical Findingsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Immunohistochemical Analysis of Biodentine Versus MTA in Repair of Experimental Furcation Perforation

Badr¹,

Abu‐Seida²,

Hashem³

et al. 2020

Preprint

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Radiographic and immuno-histochemical evaluation of root perforation repair using MTA with or without platelet-rich fibrin or concentrated growth factors as an internal matrix in dog’s teeth: in vivo animal study

et al. 2023

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Objectives To comparatively evaluate the in vivo outcome of MTA repair for contaminated and non-contaminated furcation perforations (FP) with or without PRF and CGF as a matrix in dogs’ teeth. Methods Ninety dog teeth were divided into five groups based on the iatrogenic FP repair approach after doing root canal treatment: negative control (without FP), positive control (FP without repair), MTA, MTA + PRF and MTA + CGF groups, where FP were repaired promptly in subdivision 1 (n = 10; non-contaminated) and after 4 weeks of oral contamination in subdivision 2 (n = 10;contaminated). After 3 months, the perforation site was assessed radiographically (vertical bone density), histologically (inflammatory cell count, epithelial proliferation, cementum and bone deposition) and immunohistochemically (OPN and TRAP antibodies localisation). Data collected were statistically analysed using SPSS software at a 0.05 significance level. Results The MTA + PRF and MTA + CGF groups demonstrated significantly more bone formation, OPN immunolocalisation and fewer inflammatory cell counts than MTA group. MTA, MTA + PRF and MTA + CGF groups showed significantly favourable radiographic, histological and immunohistochemical healing features than the positive control, especially in non-contaminated subdivisions, that significantly showed better features than the contaminated subdivisions (P < 0.001). Conclusion The use CGF and PRF as a matrix beneath MTA in FP repair in dog’s teeth is promising as it could increase hard and soft tissue regeneration in non-contaminated and contaminated perforations. Clinical relevance The repair of FP is challenging especially when associated with contaminated inter-radicular bone loss. Radiographic, histological and immunohistochemical comprehensive evaluation of the root and surrounding attachment apparatus response to different perforation repair protocols could give a predictable clinical outcome.

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Regenerative potential of immature permanent non-vital teeth following different dentin surface treatments

Ashry

Abu‐Seida

Bayoumi

et al. 2016

Experimental and Toxicologic Pathology

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Histologic Evaluation of Furcation Perforation Treated with Mineral Trioxide Aggregate and Bioaggregate

Cited by 15 publications

References 22 publications

Immunohistochemical Analysis of Biodentine Versus MTA in Repair of Experimental Furcation Perforation

Immunohistochemical Analysis of Biodentine Versus MTA in Repair of Experimental Furcation Perforation

Radiographic and immuno-histochemical evaluation of root perforation repair using MTA with or without platelet-rich fibrin or concentrated growth factors as an internal matrix in dog’s teeth: in vivo animal study

Regenerative potential of immature permanent non-vital teeth following different dentin surface treatments

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