Histologic Evaluation of a Q-Switched Nd:YAG Laser in the Nonablative Treatment of Wrinkles

Goldberg, David J.; Silapunt, Sirunya

doi:10.1046/j.1524-4725.2001.00353.x

Cited by 100 publications

(90 citation statements)

References 21 publications

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“…As Goldberg suggested, non-ablative skin rejuvenation is based on the theory of delivering a useful packet of photothermal damage to the upper dermis under a cooled epidermis, thereby initiating the wound healing process under the biological protection of an intact epidermis and achieving the required collagen synthesis and remodeling [3]. Based on the theory of selective photothermolysis [21], the four lasers we applied in this study target different chromospheres.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, because of the scattering effect of tissue at this wavelength, the area of the highest photon density, and thus the photo-thermal effect, is not at the surface of the tissue, but some 1-2 mm below the surface [20]. The Q-switched 1,064-nm Nd:YAG laser is characterized by very short pulse width, which produces the dermal damage mainly by the photo-mechanical effect; moreover, the Q-switched laser has less water absorption and lower scattering, which results in a relatively deeper dermal wound [3].…”

Section: Discussionmentioning

confidence: 99%

“…They found that the Q-switched 1,064-nm Nd:YAG laser provides satisfactory clinical results with no post-operative morbidity in the treatment of periocular and perioral rhytides. Later Goldberg performed a series of clinical studies with histologic examinations to prove the collagen remodeling effects of Q-switched 1,064-nm Nd:YAG laser [2,3]. The 1,320-nm Nd:YAG laser with a dynamic surface cooling device was the first laser system specifically designed for the purpose of non-ablative skin rejuvenation [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

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Laser induced collagen remodeling: A comparative study in vivo on mouse model

et al. 2008

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Background and Objective: Many lasers have claimed the clinical efficacy on skin rejuvenation. In this study, the mechanisms of laser induced collagen remodeling were explored systematically on a Kunming (KM) mouse model in vivo by comparing the different non-ablative laser effects using four different laser treatment modalities. Materials and Methods: The dorsal skin of KM mice was exposed by depilation before the laser treatments. Four laser treatment modalities were used: the 595-nm pulsed dye laser (PDL) (10 ms), 1,320-nm neodymium-yttriumaluminum garnet (Nd:YAG) laser (0.35 ms), 1,064-nm Nd:YAG laser with Q-switched (5 ns), and long-pulsed (0.3 ms) mode. Each modality exposed one side of the mouse dorsal skin leaving the other side as the contralateral control. Then skin histology, fibroblast number, and the genesis of collagen type I and III were studied by comparing the treatment site and control site at 1 hour, 1 day, 1 week, 3 weeks, 4 weeks, and 8 weeks after laser treatment. Hydroxyproline content of the skin tissue was measured 4 weeks and 8 weeks after laser exposure. Results: All laser treatments led to marked improvements in dermal layer thickness and collagen fiber density, and the increase in fibroblast number and hydroxyproline content compared with their own controls. Collagen synthesis and remodeling induced by the Q-switched 1,064-nm laser was most effective 4 weeks after treatment, while there was no significant difference among the other three modalities. Among the new collagen genesis after the different laser treatments, collagen type III increased sharply after the Q-switched 1,064-nm laser treatment whereas more collagen type I was elicited by the other laser treatment modalities. Conclusions: The efficacy of photo-mechanical effects in promoting more effectively the synthesis of collagen type III, whereas the photo-thermal effect favored more the formation of collagen type I.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Laser induced collagen remodeling: A comparative study in vivo on mouse model

et al. 2008

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“…It is well established that skin injury such as scarification or burn can enhance immune responses 40 and lasers can be used to induce such injuries to the skin. 39,[41][42][43] A number of investigators have explored the immune-stimulating effects of thermally-destructive lasers in treating cancer 44,45 and a recent review has been published covering this approach. 46 In addition, fractional laser devices used to enhance delivery of drugs and vaccines have been examined for their ability to alter immunologic responses in the skin to vaccines and immunotherapies.…”

Section: Potential Role Of Lasers As Vaccine Adjuvantsmentioning

confidence: 99%

Laser vaccine adjuvants

Kashiwagi¹,

Brauns

Gelfand

et al. 2014

Human Vaccines & Immunotherapeutics

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“…Unlike other complications, some of the hypopigmented lesions are irreversible in spite of active treatment for repigmentation over a long time span. [7][8][9][10][11][12][13] Precautions about the risk of hypopigmentation with laser toning is somewhat justified in that it can lead to better treatment outcome, however, excessive fear may not be helpful. Such an overblown fear may have stemmed from several reports such as case series of facial depigmentation associated with low fluence Q-switched 1,064 nm Nd:YAG laser for skin rejuvenation and melasma which emphasized the risk of hypopigmentation with laser toning, questioning the appropriateness of using laser toning in the treatment of melasma.…”

Section: Introductionmentioning

confidence: 99%

Mottled Hypopigmentation from Laser Toning in the Treatment of Melasma: A Catastrophic or Manageable Complication?

Park

Yeo²

2015

Medical Lasers

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Melasma is a common acquired pigmentary disorder and difficult to treat with a high rate of recurrence. Conventional methods in the treatment of melasma have drawbacks and limitations. The so-called "laser toning" treatment, which uses a collimated low-fluence 1,064 nm Q-switched neodymium-doped yttrium aluminum garnet laser, was introduced a few years ago for the treatment of melasma. Laser toning has attracted much popularity and attention, and has become a crucial method for treatment of melasma. Laser toning is now a mainstay for treatment and management of melasma, however some dermatologists have excessive concerns about the risk of hypopigmentation. This inordinate fear may have originated from a few studies which insisted that laser toning therapy has a high risk of hypopigmentation and should be considered as a second-line treatment, not a first-line treatment for melasma. In the current study, we suggest that hypopigmentation after laser toning is a preventable and controllable complication based on our clinical experiences and reviews of various literatures. Key words

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Histologic Evaluation of a Q-Switched Nd:YAG Laser in the Nonablative Treatment of Wrinkles

Abstract: The Q-switched Nd:YAG laser produced morphologic changes similar to, but lesser in degree, than those seen with both CO2 and Er:YAG laser resurfacing.

Cited by 100 publications

References 21 publications

Laser induced collagen remodeling: A comparative study in vivo on mouse model

Laser induced collagen remodeling: A comparative study in vivo on mouse model

Laser vaccine adjuvants

Mottled Hypopigmentation from Laser Toning in the Treatment of Melasma: A Catastrophic or Manageable Complication?

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