Histologic comparison of polylactic and polyglycolic acid sutures

Cutright, Duane E.; Beasley, J. N.; Perez, Bienvenido

doi:10.1016/0030-4220(71)90265-9

Cited by 107 publications

(25 citation statements)

References 2 publications

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“…lc). The thickness of the capsule at 6 months was around 300 to 400 lam and there was a thicker (3)(4)(5) After 1 year of implantation, the inflammatory process subsided. The capsule consisted mainly of mature collagen fibres, The cellularity of the capsule and its thickness decreased.…”

Section: Macroscopic Findingsmentioning

confidence: 99%

“…Polylactides were found to be biocompatible. The typical tissue reaction to polylactides may involve fibroblasts, histocytes, lymphocytes, mast cells, foreign body giant cells, macrophages, plasma cells, eosinophils, and lymphoid cells [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. The type of cells present at the implantation site may vary depending on the implant purity (i.e.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Long-term soft tissue reaction to various polylactides and their in vivo degradation

Mainil‐Varlet

Gogolewski

Nieuwenhuis

1996

J Mater Sci: Mater Med

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Cylindrical pins made from poly(L-lactide), poly(L/D-lactide) 95/5% and poly(L/DL-lactide) 95/5% were implanted in the subcutaneous tissue of sheep. The tissue reaction to the implanted materials and their in vivo degradation was investigated at 1,3, 6 and 12 months. The capsule formed around the polylactide implants consisted of fibroblasts, fibrocytes, phagocytes, a few foreign body giant cells and polymorphonuclear cells. For all three polylactides used, the cellular response was most intensive during the first 6 months of implantation and significantly subsided at 1 year. The thickness of the capsule was 200 }am at 1 month, increased to 200-600 }am at 6 months, and decreased to 100 to 200 }am at 1 year, depending on the material used. The tissue reaction was more intense for poly(L/D-lactide) than for poly(L/DL-lactide) and poly(L-lactide). The drop in molecular weight of the implants was highest after 1 month of implantation (70 to 95%). Irrespective of the extensive reduction of the molecular weight at 1 month, none of the polymers used was completely resorbed at 1 year. The most advanced resorption was observed for poly(L/D-lactide). Despite molecular weight reduction, the poly(L-lactide) implants had maintained 70% of their initial bending strength and 95% of their shear strength at 3 months. The poly(L/D-lactide) and poly(L/DL-lactide) had maintained only 26 to 27% of their initial bending strength and 26 to 31% of the initial shear strength, respectively. The crystallinity of all the materials increased after implantation as compared with nonimplanted materials. The overall crystallinity increase and the final crystallinity reached by the materials at 1 year was, however, lowest for poly(L/DL-lactide) as compared with the other two polylactides.

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Section: Macroscopic Findingsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Long-term soft tissue reaction to various polylactides and their in vivo degradation

Mainil‐Varlet

Gogolewski

Nieuwenhuis

1996

J Mater Sci: Mater Med

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“…The animals were followed for 38 weeks, at which time it was found that the implants were well tolerated but not completely absorbed although phagocytosis of polymer fragments was occurring. Cutright and co-workers [40] also studied the degradation of polylactic acid sutures in rats and found gradual degradation lasting beyond the 90-day observation period. Gregory, et al [41] prepared and evaluated polylact:ic acid films as burn dres sings; at thicknesses required to control water loss, polylactic acid was found to be too stiff and unconforming to be of value in this application.…”

Section: A-polyester Homopolymersmentioning

confidence: 95%

Biodegradable Polymers in Medicine and Surgery

Kronenthal¹

1975

Polymers in Medicine and Surgery

102

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“…The biodegradable polymers can also be synthesized by the polycondensation polymerization of either hydroxyacids or diols and diacids or by polymerization of cyclic diesters, glycolides, lactides, and lactones [57,59]. In the view of biomedical areas, the monomers primarily used for aliphatic polyester synthesis are lactide, glycolide, and caprolactone [58].…”

Section: Aliphatic Polyestermentioning

confidence: 99%

“…These polyesters have been used as sutures [59] fixtures and plates for fracture fixation devices [60] and scaffolds for transplantation of cell [61].…”

Section: Aliphatic Polyestermentioning

confidence: 99%