Histologic Comparison of Light Emitting Diode Phototherapy-Treated Hydroxyapatite-Grafted Extraction Sockets: A Same-Mouth Case Study

Brawn, Peter; Kwong-Hing, A.

doi:10.1097/id.0b013e318065a84c

Cited by 21 publications

(17 citation statements)

References 22 publications

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“…19,43 OsseoPulse ® LED device photobiomodulation was found to enhance bone formation and particle resorption in HA particulate-grafted fresh extraction sockets. 44 In another study by OsseoPulse ® LED device, a favorable effect on healing and stability of 12 titanium orthodontic miniscrews was reported. 45 The results of our study and those of others indicated that bone irradiated with LED arrays showed increased neovascularization, collagen deposition, and bone neorformation compared to non-irradiated bone.…”

Section: Discussionsupporting

confidence: 74%

Effects of Light-Emitting Diode Photobiomodulation Therapy and BioOss as Single and Combined Treatment in an Experimental Model of Bone Defect Healing in Rats

Havlucu

Bölükbaşı

Yeniyol

et al. 2015

Journal of Oral Implantology

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The present study assesses histopathologically and histomorphometrically the effects of light-emitting diode (LED) photobiomodulation therapy (LPT) on bone healing in BioOss-filled femoral defects of rats. It has been reported that LPT modulates cellular metabolic processes, leading to an enhanced regenerative potential for biological tissues. Thirty-six male Wistar rats with femoral bone defects were divided into 4 groups: defect group (empty bone defect, without application of LPT), graft group (bone defect filled with BioOss, without application of LPT), (defect+LPT) group (empty bone defect, with application of LPT), and (graft+LPT) group (bone defect filled with BioOss, with application of LPT). An OsseoPulse LED device (wavelength: 618 nm; output power: 20 mW/cm(2)) was initiated 24 hours postsurgery and performed every 24 hours for 7, 14, and 21 days. The LPT-applied and BioOss-filled defects presented a higher amount of new bone formation with trabeculae formation. These defects showed statistically significant lower values of inflammation severity, and fewer remnants of biomaterial were present. Within the limitations of this study, LPT has positive effects on bone healing histopathologically and histomorphometrically for the defects filled with BioOss 3 weeks after the rats' femora injury.

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Section: Discussionsupporting

confidence: 74%

Effects of Light-Emitting Diode Photobiomodulation Therapy and BioOss as Single and Combined Treatment in an Experimental Model of Bone Defect Healing in Rats

Havlucu

Bölükbaşı

Yeniyol

et al. 2015

Journal of Oral Implantology

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“…Several studies have suggested that the use of PBM is one of the most suitable protocols for improving bone repair due to its larger penetration depth in the bone tissue when compared to visible light [19]. Although several studies have demonstrated positive results in the healing of bone tissue with the use of PBM, there are yet few reports on the use of combinations of PBM and biomaterials [20,21]. The effects of PBM in bone repair associated with graft biomaterials needs to be further studied as each material may cause different responses.…”

Section: Introductionmentioning

confidence: 99%

“…As light has been proved to speed up bone repair, it would be desirable to develop a technique to enhance and shorten the time of bone repair in cases of the use of biomaterials [20]. The aim of this study was to histopathologically evaluate the effect of PBM and locally applied simvastatin on bone formation in 5 mm critical sized defects (CSDs) formed in rat calvaria.…”

Section: Introductionmentioning

confidence: 99%

Histopathologic evaluation of the effects of local simvastatin application and photobiomodulation by light-emitting diode on bone healing of rat calvarial defects

Burdurlu

Deniz

Olgaç

2017

Biotechnology & Biotechnological Equipment

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The purpose of this study was to evaluate the effect of photombiomodulation (PBM) and locally applied simvastatin on bone formation in critical size defects of the experimental rat model calvarium. A total of 28 Spraque-Dawley male rats, mean age of 18 weeks, were used. Bilateral 5 mm critical sized calvarial defects were created. Then 0.5 mg/mL simvastatin solution was inoculated into gelatin sponge and locally applied on one side. The other side served as control.Half of the animals were subjected to PBM treatment and the remaining half were left for spontaneous healing. The animals were sacrificed by guillotine at days 8 and 15. The specimens were histopathologically analysed. The histopathologic evaluation revealed that the new bone formation levels were significantly higher at the 15th day compared to the 8th day. The bone formation levels with PBM and simvastatin treatment either combined or applied individually were significantly higher than the control ones. PBM and local simvastatin applications had favourable effects on the early phase of new bone formation and reduced the bone healing period in the rat model. Further human trials must be performed for evaluation of the reliability of this protocol.

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“…As a result of this stimulation of the respiratory chain in the mitochondria, adenosine triphosphate (ATP) production is increased [16]. It is postulated that this increased ATP production and consequent energy source for the cellular machinery allows for increased function and metabolism of cells in tissues that are ischemic, wounded, intoxicated, or poorly perfused [17].…”

Section: Introductionmentioning

confidence: 99%

Effect of Diode Laser on Healing of Tooth Extraction Socket: An Experimental Study in Rabbits

Hamad

Naif

Abdullah

2015

J. Maxillofac. Oral Surg.

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Objectives To evaluate the effect of low-level laser therapy on healing of extracted tooth socket of healthy rabbits. Design The sample of this study was 20 male rabbits of 2-2.5 kg weight with age range of 8-12 months. Right and left lower first premolar teeth were extracted. The extraction sockets of lower right first premolar were irradiated with 0.9 W gallium-aluminum-arsenide (GaAlAs) diode laser for 5 min, immediately after extraction and then every 72 h for the next 12 days. The extraction socket of left side were not exposed to laser and served as a control. The animals were sacrificed after 7, 14, 30 and 45 days and the experimental and control sockets were removed from the harvested mandibles and prepared for haematoxylin and eosin staining and Masson's stain. The prepared slides were examined under light microscope for histological and histomorphometric examination. Results The histological examination showed that diode laser-treated sockets demonstrated early formed new bone with faster maturation of primary bone to secondary bone as compared to non-treated control sockets. Histomorphometric analysis revealed a statistically significant increase in the density and volume of trabecular bone in lasertreated sockets than control sockets. Conclusion Diode laser application to tooth extraction socket has a positive effect on bone formation.

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Histologic Comparison of Light Emitting Diode Phototherapy-Treated Hydroxyapatite-Grafted Extraction Sockets: A Same-Mouth Case Study

Abstract: The accelerated bone healing in the phototherapy-treated HA socket graft may provide faster implant placement compared to non-phototherapy-treated socket grafts.

Cited by 21 publications

References 22 publications

Effects of Light-Emitting Diode Photobiomodulation Therapy and BioOss as Single and Combined Treatment in an Experimental Model of Bone Defect Healing in Rats

Effects of Light-Emitting Diode Photobiomodulation Therapy and BioOss as Single and Combined Treatment in an Experimental Model of Bone Defect Healing in Rats

Histopathologic evaluation of the effects of local simvastatin application and photobiomodulation by light-emitting diode on bone healing of rat calvarial defects

Effect of Diode Laser on Healing of Tooth Extraction Socket: An Experimental Study in Rabbits

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