Histologic Classification of Sinonasal Intestinal-Type Adenocarcinoma

Franquemont, Douglas W.; Fechner, Robert E.; Mills, Stacey E.

doi:10.1097/00000478-199104000-00005

Cited by 87 publications

(38 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The histogeneis of this rare histotype of the sinonasal tract is unclear. The most plausible hypothesis is an origin from a transformed duct epithelium [12][13][14][15][16][17]. Transformation of the non-neoplastic respiratory epithelium of the sinonasal tract to an intestinal phenotype, adjacent to adenocarcinoma, has been reported [7,[18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

Primary Intestinal-Type Adenocarcinoma of Tongue: A Case Report with Immunohistochemical and Molecular Profiles and Review of the Literature

Rahimi

Akaev

Repanos

et al. 2016

Head and Neck Pathol

View full text Add to dashboard Cite

Primary lingual intestinal-type adenocarcinomas are extremely rare with only a few cases described. A case with immunohistochemical expression of Androgen Receptor (AR) which was treated solely by chemo-radiotherapy is reported herein. A 54-year-old male was referred with symptoms of fullness in his tongue. Clinical examination showed an asymmetry of the tongue with a hard mass palpable within the middle of the tongue. Biopsy showed intestinal-type adenocarcinoma. The tumour showed positive staining with cytokeratin 7, cytokeratin 20, CDX2, AR, b-catenin and was mismatch repair proteins (MMR) proficient. The molecular analysis did not show mutations in the KRAS, NRAS, BRAF and PIK3CA genes. The patient was treated with radiochemotherapy and is in remission 3.5 years after the diagnosis. This is the first case of intestinal-type tongue adenocarcinoma which showed AR expression and was treated solely with radical chemoradiotherapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Primary Intestinal-Type Adenocarcinoma of Tongue: A Case Report with Immunohistochemical and Molecular Profiles and Review of the Literature

Rahimi

Akaev

Repanos

et al. 2016

Head and Neck Pathol

View full text Add to dashboard Cite

show abstract

“…They resemble intestinal epithelium in the normal, dysplastic and malignant states [16]. They often arise in the ethmoid sinus, which represents an unusual location for sinonasal hamartoma and are associated with wood dust and other occupational exposures [2,16,17]. They are readily distinguished by their typical staining for CK20 and/or CDX2, a feature not seen in sinonasal hamartomas.…”

Section: Low Grade Sinonasal Adenocarcinomamentioning

confidence: 99%

Low Grade Glandular Lesions of the Sinonasal Tract: A Focused Review

Weinreb

2010

Head and Neck Pathol

View full text Add to dashboard Cite

The sinonasal tract is a complex anatomic site with an exhaustive list of possible diagnoses. While most biopsies or resections encountered routinely consist of common diagnoses such as inflammatory polyps and papillomas, occasional cases are more difficult, and separating reactive or benign from malignancy can be challenging. One of the most poorly understood and daunting categories is low grade glandular or tubular proliferations, particularly on small biopsies. Possible diagnoses such as reactive lesions, respiratory epithelial adenomatoid hamartoma (REAH), seromucinous (glandular) hamartoma (SH) and low grade sinonasal adenocarcinomas (LGSNAC) must be entertained. REAH is composed of respiratory epithelial lined submucosal glands with variable connection to the surface and periglandular hyalinization. SH is a tubular proliferation reminiscent of normal serous glands which may be associated with REAH.LGSNAC is a diverse group of bland tubular and/or papillary tumors, which have a recurrence potential but an as yet uncertain potential for metastasis or mortality. The management for these lesions can be vastly different and conservative management is preferable, making this distinction more than academic. However, complicating this category are controversies surrounding their nature as reactive lesions versus neoplasms, the histologic and immunohistochemical overlap, and possible precursor relationships between some of them.

show abstract

“…They further divided their PTCC variant into three additional subtypes: I (well differentiated), II (moderately differentiated), and III (poorly differentiated). In a collective review of 152 ITACs either initially classified and/or reclassified according to this scheme, 27 (18%) were PTCC I, 54 (36%); PTCC II, 31 (20%); and PTCC III, 19 (13%) alveolargoblet cell, 5 (3%) signet ring cell, and 16 (11%) transitional (123,(131)(132)(133).…”

Section: Pathologymentioning

confidence: 99%