Histologic assessment of regenerating rat liver under low-dose rate radiation exposure

Guryev, D.

doi:10.1016/j.ics.2004.11.044

Cited by 5 publications

(5 citation statements)

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“…The histological examination results included in the current study revealed that fractionated dose 8 Gy of γ-irradiation induced different histopathological changes indicated by loss of the normal hepatic architecture began with dilatation of the central vein and hepatic blood sinusoids, vacuolation and degeneration of its cytoplasm, pyknosis, and activation of Kupffer cells. The current results run in parallel with those reported earlier [35,36].…”

Section: Discussionsupporting

confidence: 90%

Studies on the Effect of Curcumin and Quercetin in the Liver of Male Albino Rats Exposed to Gamma Irradiation

Ali

Azzoz

Soliman

et al. 2023

Preprint

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Ionizing radiation produces deleterious effects on living organisms. The present investigation has been carried out to study the prophylactic as well as the therapeutic effects of treated rats with quercetin (Quer) and curcumin (Cur) which are two medicinal herbs known for their antioxidant activities against damages induced by whole-body fractionated gamma irradiation. Exposure of rats to whole-body gamma irradiation induced a significant decrease in erythrocyte (RBC), leukocyte (WBCs), platelets count (Plt), hemoglobin concentration (Hb), hematocrit (Hct %), mean erythrocyte hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) and mean erythrocyte volume (MCV), high increase in plasma Thiobarbituric acid reactive substances (TBARS), non-significant statistical decrease in the mean value of serum glutathione (GSH), with a significant increase in plasma alanine transferase (ALT), aspartate transferase (AST), alkaline phosphates (ALP), serum total protein, serum total cholesterol levels, total triglycerides levels, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) levels with marked histological changes and structural changes measured by Fourier Transform Infrared (FTIR). Applying both quercetin and curcumin pre- and post-exposure to gamma-radiation revealed a remarkable improvement in all the studied parameters. The cellular damage by gamma radiation is greatly mitigated by the coadministration of curcumin and quercetin before radiation exposure.

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Section: Discussionsupporting

confidence: 90%

Studies on the Effect of Curcumin and Quercetin in the Liver of Male Albino Rats Exposed to Gamma Irradiation

Ali

Azzoz

Soliman

et al. 2023

Preprint

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“…In addition, the increase in lymphocyte infiltrations and fibrocytes were demonstrated. Similar results were documented by many authors on different experimental animals exposed to gammaradiation (Yarmonenko, 1998, Zavodnik et al, 2003and Guryev, 2005. Degeneration and necrosis of the hepatic cells following exposure to radiation could be explained according to the suggestion of Ritter (1977) who reported that liver cell necrosis may be either due to progressive degenerative action of intracellular enzymes of the injured cells or to a metabolic disturbance and inhibition of synthesis needed of DNA and hence protein synthesis for the growth and maturation of the liver.…”

Section: Discussionsupporting

confidence: 90%

“…Also, electron microscopy revealed different binucleated hepatocytes in animals treated with β-carotene for two weeks and then exposed to γ-radiation. Guryev (2005), suggested that a high number of binucleated hepatocytes could be produced as a result of the cell dividing damage (acytokinesis) that could lead to adaptive response to low-dose rate radiation. Similarly, Korolev et al (1996) showed that an intake course of sulphate mineral water after total radiation (1 and 5 Gy) can prevent and minimize dystrophic and necrobiotic changes in the liver, stimulate intracellular regeneration and reduce pathological mitosis.…”

Section: Discussionmentioning

confidence: 99%

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EFFECT OF GAMMA RADIATION ON THE ALBINO RAT'S LIVER AND THE POSSIBLE PROTECTIVE ROLE OF Β-Carotene ON THE HISTOLOGICAL AND ULTRA STRUCTURAL CHANGES

Rady

Nour

Khalil

2008

The International Conference on Chemical and Environmental Engi

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The present investigation reports the possible protective effect of β-carotene against hepatic lesions induced in male albino rats due to γ-irradiation. 48 male albino rats were divided into three main groups; the first group served as control (12 rats). Rats of the second group (18 rats) were exposed to a sub-lethal dose of whole body γirradiation and then divided into three equal subgroups. The rats of the third main group (18 rats) received 5mg/kg body wt of β-carotene at a daily oral dose for 2 consecutive weeks, and were then subjected to whole body γ-irradiation at sub-lethal single dose level of 6Gy (Gray). This group was then divided into three equal subgroups. The rats were autopsied at three intervals; one week, two weeks and four weeks post irradiation. The obtained data revealed that γ-irradiation-induced different histological changes in the liver of irradiated rats. These changes varied from haemorrhage, congestion in blood vessels, pyknosis and necrosis as well as complete degenerated areas in the liver. Electron micrographs recorded swollen mitochondria, fragmented endoplasmic reticulum, distorted nuclei and cell membrane and lipid infiltration in the hepatocytes of irradiated animals. The treatment with βcarotene (5 mg/ kg body wt for two consecutive weeks) pre-exposure to radiation attenuated most of these changes. Therefore, the present study has concluded the potential use of β-carotene dissolved in corn oil as a radio protector.

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“…Moreover, our data demonstrated that the liver of ratsexposed to gamma rays resultedin diverse lesions withdilated blood vessels and pyknosis, hemorrhage, vacuolation, and necrobiotic alterations in the hepatocytes. Similar results were recognized to that in (Zavodnik et al 2003);Guryev 2005). Additionally, tissue of irradiated rats showed brosis, which is the most commondelayed effect of radiation, a lack of parenchymal hepatocytes, and deformation of the lobular architecture associated with both per-central and per-portal brosis (Yıldızhan et al 2020).…”

Section: Discussionsupporting

confidence: 73%

Nanoparticles for active combination radio mitigating agents of Zinc Coumarate and Zinc Caffeiate in a rat model

et al. 2021

Preprint

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Zinc Coumarate and zinc caffeiatenano-particles (ZCoNPs, ZCaNPs) have been shown to affectthe different biological processes. This work was undertaken to evaluate the mitigating action of ZCoNPs in combination with ZCaNPsagainst liver damage induced by gamma rays (γ-rays). Rats were exposed to 7Gy of γ-rays, and theninjected intraperitoneally (i.p.) with ZCoNPs [2U / rat / day (5 mg/kg)], and ZCaNPs [2U / rat / day (15 mg/kg)] for 7 consecutive days.The results showed that irradiated rats treated with ZCoNPs (5 mg/kg/body weight) in combination with ZCaNPs (15 mg/kg/body weight) for 7 days revealed a significant increase in the body weight, antioxidants levels, T Helper (CD4) Cell and T Cytotoxic (CD8), associated with amarked decrease in the level of lipid peroxidation (LP), nitric oxide(NOx), total free radicals concentrate (TFRC), and DNA fragmentation. Moreover, positive alterations in the morphological state, hematological parameters, and thecell cycle phases were noticed. Additionally, the histopathological study demonstrated an improvement in the liver tissue of irradiated rats after treatment.Thus, ZCoNPs and ZCaNPscould be usedas a natural mitigating agent to reduce the hazards of ionizing radiation.

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Histologic assessment of regenerating rat liver under low-dose rate radiation exposure

Cited by 5 publications

References 1 publication

Studies on the Effect of Curcumin and Quercetin in the Liver of Male Albino Rats Exposed to Gamma Irradiation

Studies on the Effect of Curcumin and Quercetin in the Liver of Male Albino Rats Exposed to Gamma Irradiation

EFFECT OF GAMMA RADIATION ON THE ALBINO RAT'S LIVER AND THE POSSIBLE PROTECTIVE ROLE OF Β-Carotene ON THE HISTOLOGICAL AND ULTRA STRUCTURAL CHANGES

Nanoparticles for active combination radio mitigating agents of Zinc Coumarate and Zinc Caffeiate in a rat model

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