Histologic artifacts of benign pigmented nevi

Sagebiel, RichardW.

doi:10.1097/00006534-197304000-00065

Cited by 6 publications

(9 citation statements)

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“…The mechanisms of pseudovas-cular structure in me1anocytic nevus are still unknown. There have been several reports that this unusual finding is an artifact of injection or tissue-processing (2)(3)(4).…”

Section: Introductionmentioning

confidence: 99%

The Vascular Space‐like Structure in Melanocytic Nevus Is Not an Injection Artifact: Report of a Case and an Experimental Study

Demitsu

Kakurai

Yamada

et al. 1998

The Journal of Dermatology

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Melanocytic nevi may microscopically associate with clefts or slits of the nests resembling lymphatic or vascular spaces. This unique histologic feature has been known as an artifact of injection or tissue-processing. We present a case of melanocytic nevus with a prominent vascular space-like structure. We also studied whether intralesional injection of local anesthetic could reproduce similar histologic findings. A 45-year-old Japanese female visited us with a solitary, brownish papule on the chest. Histology revealed numerous nests composed of round to oval-shaped nevus cells throughout the entire dermis. In the mid-dermis, nevus cells were lined up in a layer anastomosing and forming a vascular space-like structure. These nevus cells were uniformly stained with vimentin and S100 protein but not with factor VIII-related antigen. They were also positively immunoreactive with anti-type IV collagen and anti-fibronectin. There were no significant differences in staining intensity in the nevus cells between the solid portion and the vascular space-like structure. In the experimental study, eight melanocytic nevi were removed under local anesthesia. The local anesthetic solution was then injected into the excised nevus. Intralesional injection of a considerable volume of local anesthetic was capable of causing slits or clefts of the nests and dermal edema; however, it failed to reproduce a vascular space-like structure similar to that in the present case. These findings suggest that a vascular space-like structure in melanocytic nevus is not caused by the injection alone. Some other factor(s) may play a major role in the development of such structures in melanocytic nevus.

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Section: Introductionmentioning

confidence: 99%

The Vascular Space‐like Structure in Melanocytic Nevus Is Not an Injection Artifact: Report of a Case and an Experimental Study

Demitsu

Kakurai

Yamada

et al. 1998

The Journal of Dermatology

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“…Sagebiel described those pseudovascular changes in 1972 and attributed them to shrinkage and separation of melanocytes secondary to fixation and processing of the specimen. 15 His interpretation was subsequently confirmed by other authors. 16,17 An alternative explanation of vessel-like spaces in melanocytic nevi was offered by Collina and Eusebi in 1991, namely, defective production or increased degradation of constituents of the basal lamina that allows melanocytes of a nevus to detach from one another.…”

Section: Discussionmentioning

confidence: 62%

“Tubular Spitz's nevus”– an artifact of fixation?

et al. 2000

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“…Sometimes, atypical features in nevi arise as histologieal artefacts (Sagebiel 1972), or in nevi that recur after shave-excision (Kornberg & Ackerman 1975).…”

Section: Discussionmentioning

confidence: 99%

Melanocytic Nevi

Bhawan

1979

J Cutan Pathol

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Histologic artifacts of benign pigmented nevi

Cited by 6 publications

References 0 publications

The Vascular Space‐like Structure in Melanocytic Nevus Is Not an Injection Artifact: Report of a Case and an Experimental Study

The Vascular Space‐like Structure in Melanocytic Nevus Is Not an Injection Artifact: Report of a Case and an Experimental Study

“Tubular Spitz's nevus”– an artifact of fixation?

Melanocytic Nevi

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