Histologic and Ultrastructural Findings in Human Corneas After Successful Laser In Situ Keratomileusis

Transient light-sensitivity syndrome after laser in situ keratomileusis with the femtosecond laser

“…In our experience, confocal microscopy after femtosecond LASIK in asymptomatic eyes can also show activated keratocytes, suggesting this is a nonspecific finding and activated keratocytes may be present after uneventful photorefractive keratectomy or following normal corneal healing after conventional LASIK with no photophobia. 9,10 Another finding in our study was the relationship between DLK and TLSS. The incidence of DLK in the postoperative period was significantly related to TLSS development.…”

Transient light sensitivity after femtosecond laser flap creation: Clinical findings and management

“…However, these cells are also seen in patients with no symptoms. Activated keratocytes are a feature of normal healing after LASIK, 9,10 and they have been reported to occur after other refractive procedures as well. The reduction in TLSS cases after laser energy settings were lowered supports secondary effects of laser pulse energy, such as shock wave exposure on local keratocytes or corneal nerve endings, as an etiology.…”

Histologic, Ultrastructural, and Immunofluorescent Evaluation of Human Laser-Assisted In Situ Keratomileusis Corneal Wounds

“…18 We examined a total of 92 postmortem eye-bank corneas from 48 patients who had LASIK and died for unrelated reasons. We previously described the histopathologic analysis and ultrastructure from 4 corneas of 2 patients 19 and have submitted another publication that surveys the entire LASIK cornea to describe the prevalence and spectrum of pathologic findings found in 48 corneas from 25 patients. 20 In the present study, 38 additional corneas of 20 patients were evaluated to describe in detail the changes that occur in the cellular and extracellular wound healing components of the lamellar stromal LASIK wound interface.…”