Histologic and mechanical evaluation of impacted morcellized cancellous allografts in rabbits

Yano, Helena Miyoco; Ohashi, Hirotsugu; Kadoya, Y.; Kobayashi, Akio; Yamano, Yoshiki; Tanabe, Yuji

doi:10.1054/arth.2000.6625

Cited by 11 publications

(9 citation statements)

References 22 publications

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“…Thus in this form, the various synthetic calcium‐phosphate particles function mechanically like morsellized bone graft but are slower to incorporate. In the proper environment they are osteoconductive and, over time, can become mechanically stable and infiltrated with new bone in the interparticle spaces 26–28…”

Section: Introductionmentioning

confidence: 99%

Is hydroxyapatite cement an alternative for allograft bone chips in bone grafting procedures? A mechanical and histological study in a rabbit cancellous bone defect model

et al. 2004

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To evaluate in vivo performance of hydroxyapatite cement (HAC) as a porous bone graft substitute, HAC was mixed (1:1 ratio) with either porous calcium-phosphate granules (80% tricalcium phosphate, 20% hydroxyapatite) or defatted morsellized cancellous bone (MCB) allograft and implanted bilaterally in cylindrical drill holes in distal femurs of rabbits. Groups with empty defects and impacted MCB were used for reference. After 8 weeks, one femur from each pair was examined histologically. All contralateral specimens and Time-0 specimens were used for mechanical indentation tests. Histology showed that some empty defects were filled with newly formed osteopenic bone after 8 weeks. The impacted MCB showed remodeling into new vital bone. Incorporation of the HAC/MCB composite was incomplete, whereas minimal new bone ingrowth was found in the HAC/granule composites. Though not different from each other, both composites were significantly stronger than empty defects, incorporated impacted MCB, and intact cancellous bone. At Time 0, the mechanical behavior of impacted MCB was similar to both HAC composites. In conclusion, composites of HAC and porous biomaterials can maintain relatively high strength over 8 weeks in vivo, but their incorporation into a new bony structure is slower than impacted MCB. The HAC/MCB composite showed favorable incorporation behavior.

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Section: Introductionmentioning

confidence: 99%

Is hydroxyapatite cement an alternative for allograft bone chips in bone grafting procedures? A mechanical and histological study in a rabbit cancellous bone defect model

et al. 2004

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“…Differences of mechanic properties of impacted bone grafts appear related to heterogeneity of native as well as processed bone grafts and the operative technique of impaction bone grafting (Ahmed et al 2018 ; Arts et al 2007 ; Fosse et al 2006a , 2006b ). Processing of bone reduces fat and fluid of bone transplants and correlated with increased bone density (Fosse et al 2006c ; McKenna et al 2013 ; Oakley and Kuiper 2006 ; Putzer et al 2014b ) since adding hydroxyapatite granules to allogeneic bone improved bone mineral density and bone volume fraction (Fujishiro et al 2005 ; Munro et al 2007 ; Phipps et al 2005 ; Yano et al 2000 ). Increased stiffness and compactness was found for processed compared with native cancellous bone (Cornu et al 2003 , 2004 , 2009 ; Fosse et al 2006a ; Nguyen et al 2013 ; Oakley and Kuiper 2006 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of synthetic bone replacement material of different size on shear stress resistance within impacted native and thermodisinfected cancellous bone: an in vitro femoral impaction bone grafting model

et al. 2021

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Antibiotic carrier particles of variable size might influence mechanic properties within impacted thermodisinfected and native cancellous bone different. Herafill®G containing calciumsulfate and calciumcarbonate provides high local concentrations of gentamicin being important for revision surgery in infected joint replacements. Native and thermodisinfected cancellous bone derived from 6 to 7 months old piglets was used for in vitro impaction bone grafting and supplemented each with Herafill®G granules of two different sizes. Micromovement of implants related to shear force was measured in 29 specimens distributed in 6 groups. Thermodisinfected cancellous bone revealed a significant higher shear force resistance than native bone with a mean difference of 423.8 mdeg/Nm (p < 0.001) ranging within 95% confidence interval from 181.5 to 666.0 mdeg/Nm. Adding small granules to thermodisinfected bone did not reduce shear force resistance significantly since adding large granules to native bone improved it by 344.0 mdeg/Nm (p < 0.003). Shear force resistance was found higher at the distal region of the implant compared to a proximal point of measurement throughout all specimens. Less impaction impulses were necessary for thermodisinfected bone. Thermodisinfected cancellous bone might achieve a higher degree of impaction compared with native bone resulting in increased resistance against shear force since impaction was found increased distally. Supplementation of thermodisinfected bone with small granules of Herafill®G might be considered for application of local antibiotics. Large granules appeared more beneficial for supplementation of native bone. Heterogeneity of bone graft and technical aspects of the impaction procedure have to be considered regarding the reproducibility of femoral impaction bone grafting.

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“…[4][5][6] The carrier substance should improve mechanic stability of the bone graft and promote osseous integration since adding hydroxyapatite granules to allogeneic bone improved bone mineral density and bone volume fraction. [29][30][31] The influence of addition of gentamicin containing pellets (Herafill®) consisting of calciumcarbonate and calciumsulfate on mechanical properties and morphology of impacted native and thermodisinfected cancellous bone should be evaluated. Three dimensional computertomography was performed to analyze the distribution of the bone particles and to define porosity within the impacted bone related to addition of pellets within native and thermodisinfected cancellous bone.…”

Section: Introductionmentioning

confidence: 99%

Influence of antibiotic pellets on pore size and shear stress resistance of impacted native and thermodisinfected cancellous bone: An in vitro femoral impaction bone grafting model

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Krombach

et al. 2020

Journal of Orthopaedics

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Histologic and mechanical evaluation of impacted morcellized cancellous allografts in rabbits

Cited by 11 publications

References 22 publications

Is hydroxyapatite cement an alternative for allograft bone chips in bone grafting procedures? A mechanical and histological study in a rabbit cancellous bone defect model

Is hydroxyapatite cement an alternative for allograft bone chips in bone grafting procedures? A mechanical and histological study in a rabbit cancellous bone defect model

Effect of synthetic bone replacement material of different size on shear stress resistance within impacted native and thermodisinfected cancellous bone: an in vitro femoral impaction bone grafting model

Influence of antibiotic pellets on pore size and shear stress resistance of impacted native and thermodisinfected cancellous bone: An in vitro femoral impaction bone grafting model

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