Histologic and immunohistologic study and clinical presentation of ANCA-associated glomerulonephritis with correlation to ANCA antigen specificity

Significance of Small Renal Artery Lesions in Patients with Antineutrophil Cytoplasmic Antibody-associated Glomerulonephritis

“…However, previous studies of ANCA-associated glomerulonephritis have largely focused on glomerular capillary lesions, such as necrotizing glomerulonephritis with crescent formation, and the significance of small artery vasculitis has not been investigated in much detail. In fact, only a few studies have assessed vasculitis of the small renal arteries 7,8,9,10,11 . Accordingly, we performed a retrospective investigation to determine whether the presence of small artery vasculitis had a clinical effect in patients with ANCA-associated glomerulonephritis.…”

A case of PR3–ANCA-positive anti-GBM disease associated with intrarenal arteritis and thrombotic microangiopathy

“…2f), which reflect old interstitial hemorrhage [2]. In contrast, interstitial granulomatous lesion, rare but characteristic lesion of ANCA positivity [23], was not detected. We speculate that these renal histological findings are consistent with the clinical history of 4-month preceding physical symptoms culminating in sudden-onset alveolar hemorrhage and anuric renal failure.…”

“…All cases revealed crescentic glomerulonephritis with linear IgG deposition, while intrarenal arteritis was not documented; renal histology specific for PR3-ANCA in ''double positive'' disease was not evident in previously reported cases. Since intrarenal arteritis is only detectable in one-fourth of ''pure'' ANCA-associated glomerulonephritis [23], this accumulation of intrarenal arteritis negative cases supposed to be a coincidence. However, there remains a slight possibility that the PR3-ANCA was false-positive in ''double positive'' disease.…”

A case presenting with the possible relationship between myeloperoxidase–antineutrophil cytoplasmic antibody-associated glomerulonephritis and membranous changes of the glomerular basement membrane

“…As in other glomerular diseases, areas of glomerular sclerosis have nonspecific irregular staining in MPO-ANCA-associated glomerulonephritis. The staining for IgM is most frequent and it is usually confined to or predominantly in the mesangium [19]. However, although it may be difficult to evaluate the staining intensity quantitatively, we determined the staining intensity of IgG as the 2?…”